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anti-N antibody :: Rabbit anti-Lassa virus N Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052613 anti-N antibody
Unit / Price
0.1 mg  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

N, Polyclonal Antibody

★Popular Item★
 Also Known As   

N Antibody

 Product Synonym Names    Nucleoprotein; Nucleocapsid protein; Protein N; N
 Product Gene Name   

anti-N antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS7052613 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for P13699
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Lassa virus
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Lassa virus Nucleoprotein (1-569AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-N antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-N antibody

   Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity).
 Applications Tested/Suitable for anti-N antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for N. It may not necessarily be applicable to this product.
 NCBI GI #    23343510
 NCBI GeneID    956584
 NCBI Accession #    NP_694869.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_004296.1 [Other Products]
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 UniProt Primary Accession #    P13699 [Other Products]
 Molecular Weight    62,998 Da
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 NCBI Official Full Name    nucleoprotein
 NCBI Official Symbol    LASVsSgp1 [Similar Products]
 NCBI Protein Information    nucleoprotein
 UniProt Protein Name    Nucleoprotein
 UniProt Synonym Protein Names   
Nucleocapsid protein; Protein N
 Protein Family    NIP3
 UniProt Gene Name    N [Similar Products]
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 UniProt Comments for N    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation ().
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 Research Articles on N    1. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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