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anti-NAB2 antibody :: Rabbit anti-Human NAB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497428
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NAB2, Polyclonal Antibody

★Popular Item★
 Also Known As   

NAB2 Antibody

 Product Synonym Names    EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER; NAB2; MADER
 Product Gene Name   

anti-NAB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602381
 3D Structure    ModBase 3D Structure for Q15742
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human NGFI-A-binding protein 2 protein (1-200aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12153 / sc-12151 / sc-22815
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NAB2 antibody

   Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
 Applications Tested/Suitable for anti-NAB2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NAB2 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-NAB2 antibody    Western blot
All lanes: NAB2 antibody at 3ug/ml+Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 57,35,50 kDa
Observed band size: 57 kDa

anti-NAB2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NAB2 antibody    Immunohistochemistry of paraffin-embedded human tonsil using MBS1497428 at dilution 1:100
anti-NAB2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NAB2 antibody    Immunohistochemistry of paraffin-embedded human placenta using MBS1497428 at dilution 1:100
anti-NAB2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NAB2. It may not necessarily be applicable to this product.
 NCBI GI #    5174607
 NCBI GeneID    4665
 NCBI Accession #    NP_005958.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005967.3 [Other Products]
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 UniProt Primary Accession #    Q15742 [Other Products]
 UniProt Secondary Accession #    O76006; Q14797; B2RAK3 [Other Products]
 UniProt Related Accession #    Q15742 [Other Products]
 Molecular Weight    49,748 Da
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 NCBI Official Full Name    NGFI-A-binding protein 2
 NCBI Official Synonym Full Names    NGFI-A binding protein 2 (EGR1 binding protein 2)
 NCBI Official Symbol    NAB2 [Similar Products]
 NCBI Official Synonym Symbols   
MADER
[Similar Products]
 NCBI Protein Information    NGFI-A-binding protein 2
 UniProt Protein Name    NGFI-A-binding protein 2
 UniProt Synonym Protein Names   
EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
 Protein Family    NGFI-A-binding protein
 UniProt Gene Name    NAB2 [Similar Products]
 UniProt Synonym Gene Names    MADER; Protein MADER [Similar Products]
 UniProt Entry Name    NAB2_HUMAN
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 NCBI Summary for NAB2    This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NAB2    NAB2: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Belongs to the NAB family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleus

Molecular Function: protein binding; transcription corepressor activity; transcription factor binding

Biological Process: cell proliferation; endochondral ossification; myelination; negative regulation of transcription from RNA polymerase III promoter; nervous system development; regulation of epidermis development; Schwann cell differentiation; transcription, DNA-dependent
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 Research Articles on NAB2    1. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NAB2 antibodyDiseases associated with anti-NAB2 antibody
 Reference Product  PubMed Publications
 EGR1 antibody  >51 publications with NAB2 and EGR1
 EGR2 antibody  >24 publications with NAB2 and EGR2
 EGR3 antibody  >7 publications with NAB2 and EGR3
 CHD4 antibody  >2 publications with NAB2 and CHD4
 BMP2 antibody  >1 publications with NAB2 and BMP2
 EGR4 antibody  >1 publications with NAB2 and EGR4
 Disease Name  Pubmed Publications
 Solitary Fibrous Tumors Antibodies  >35 publications with NAB2 and Solitary Fibrous Tumors
 Nervous System Diseases Antibodies  >11 publications with NAB2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >7 publications with NAB2 and Cardiovascular Diseases
 Necrosis Antibodies  >7 publications with NAB2 and Necrosis
 Fibrosis Antibodies  >6 publications with NAB2 and Fibrosis
 Breast Neoplasms Antibodies  >5 publications with NAB2 and Breast Neoplasms
 Inflammation Antibodies  >5 publications with NAB2 and Inflammation
 Disease Models, Animal Antibodies  >5 publications with NAB2 and Disease Models, Animal
 Heart Diseases Antibodies  >4 publications with NAB2 and Heart Diseases
 Hypertension Antibodies  >4 publications with NAB2 and Hypertension
Organs/Tissues associated with anti-NAB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >22 publications with NAB2 and Vascular
 Nerve Antibodies  >20 publications with NAB2 and Nerve
 Blood Antibodies  >17 publications with NAB2 and Blood
 Brain Antibodies  >15 publications with NAB2 and Brain
 Muscle Antibodies  >14 publications with NAB2 and Muscle
 Bone Antibodies  >11 publications with NAB2 and Bone
 Prostate Antibodies  >8 publications with NAB2 and Prostate
 Heart Antibodies  >6 publications with NAB2 and Heart
 Lung Antibodies  >5 publications with NAB2 and Lung
 Skin Antibodies  >5 publications with NAB2 and Skin
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