NP_066552.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NADH dehydrogenase
NCBI Official Synonym Full Names
NADH:ubiquinone oxidoreductase core subunit V2
NCBI Official Synonym Symbols
NCBI Protein Information
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
UniProt Protein Name
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
UniProt Synonym Protein Names
NADH-ubiquinone oxidoreductase 24 kDa subunit
UniProt Entry Name
NDUV2_HUMAN
NCBI Summary for NDUFV2
The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]
UniProt Comments for NDUFV2
NDUFV2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 24 kDa subunit family.
Protein type: Energy Metabolism - oxidative phosphorylation; Oxidoreductase; EC 1.6.99.3; EC 1.6.5.3; Mitochondrial
Chromosomal Location of Human Ortholog: 18p11.22
Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion; myelin sheath
Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; NADH dehydrogenase (ubiquinone) activity
Biological Process: cardiac muscle development; cellular metabolic process; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; nervous system development
Disease: Mitochondrial Complex I Deficiency
Research Articles on NDUFV2
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Products associated with anti-NDUFV2 antibody
Pathways associated with anti-NDUFV2 antibody
Diseases associated with anti-NDUFV2 antibody
Organs/Tissues associated with anti-NDUFV2 antibody
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