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anti-NOX4 antibody :: Rabbit NADPH oxidase 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176126 anti-NOX4 antibody
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NADPH oxidase 4 (NOX4), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-NADPH oxidase 4 antibody

 Product Synonym Names    NADPH oxidase 4; NADPH oxidase 4; Kidney oxidase-1 antibody; Kidney superoxide-producing NADPH oxidase antibody; KOX 1 antibody; KOX antibody; Kox-1 antibody; NADPH antibody; NADPH oxidase 4 antibody; Nox4 antibody; NOX4_HUMAN antibody; Renal NAD(P)H-oxidase antibody; RENOX antibody
 Product Gene Name   

anti-NOX4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9JHI8
 Clonality    Polyclonal
 Isotype    Rabbit IgG
 Host    Rabbit
 Species Reactivity    Human, Rat; Predicted to work with: Mouse
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 Specificity    No cross reactivity with other proteins
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of mouse NOX4(561-578aa NRNNSYGTKFEYNKES), identical to the related rat sequence and different from the related human sequence by two amino acids.
 Reconstitution    0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOX4 antibody

   NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants
 Applications Tested/Suitable for anti-NOX4 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-NOX4 antibody    Western Blot:

Concentration:0.1-0.5ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms



Immunohistochemistry (Paraffin-embedded Section):

Concentration:0.5-1ug/ml
Tested Species: Rat
Predicted Species: Hu,Ms
Antigen Retrieval: By Heat



Tested Species: In house tested species with positive results

Predicted Species: Species predicted to be fit for the product based on sequence similarities.

By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20mins is required for the staining of formalin/paraffin sections.

Other applications have not been tested.

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NCBI/Uniprot data below describe general gene information for NOX4. It may not necessarily be applicable to this product.
 NCBI GI #    81881891
 NCBI GeneID    50490
 NCBI Accession #    Q9JHI8.1 [Other Products]
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 UniProt Primary Accession #    Q9JHI8 [Other Products]
 UniProt Secondary Accession #    Q3TF39; Q8C3M1; Q8VCA3 [Other Products]
 UniProt Related Accession #    Q9JHI8 [Other Products]
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 NCBI Official Full Name    NADPH oxidase 4
 NCBI Official Synonym Full Names    NADPH oxidase 4
 NCBI Official Symbol    Nox4 [Similar Products]
 NCBI Official Synonym Symbols   
AI648021
[Similar Products]
 NCBI Protein Information    NADPH oxidase 4; KOX-1; kidney oxidase-1; renal NAD(P)H-oxidase; superoxide-generating NADPH oxidase 4; kidney superoxide-producing NADPH oxidase
 UniProt Protein Name    NADPH oxidase 4
 UniProt Synonym Protein Names   
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4
 Protein Family    NADPH oxidase
 UniProt Gene Name    Nox4 [Similar Products]
 UniProt Synonym Gene Names    Renox; KOX-1 [Similar Products]
 UniProt Entry Name    NOX4_MOUSE
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 UniProt Comments for NOX4    NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Nucleolus; EC 1.6.3.-; Membrane protein, multi-pass; Membrane protein, integral; Cell cycle regulation

Cellular Component: focal adhesion; mitochondrion; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; apical plasma membrane; integral to membrane; stress fiber; plasma membrane; cell junction; NADPH oxidase complex

Molecular Function: NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor; oxidoreductase activity

Biological Process: positive regulation of apoptosis; cell morphogenesis; superoxide metabolic process; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of stress fiber formation; superoxide release; bone resorption
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 Research Articles on NOX4    1. NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NOX4 antibodyDiseases associated with anti-NOX4 antibody
 Products by Pathway  Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >246 publications with NOX4 and Cardiovascular Diseases
 Hypertension Antibodies  >162 publications with NOX4 and Hypertension
 Inflammation Antibodies  >149 publications with NOX4 and Inflammation
 Fibrosis Antibodies  >133 publications with NOX4 and Fibrosis
 Heart Diseases Antibodies  >106 publications with NOX4 and Heart Diseases
 Atherosclerosis Antibodies  >93 publications with NOX4 and Atherosclerosis
 Kidney Diseases Antibodies  >90 publications with NOX4 and Kidney Diseases
 Hypertrophy Antibodies  >84 publications with NOX4 and Hypertrophy
 Necrosis Antibodies  >59 publications with NOX4 and Necrosis
 Lung Diseases Antibodies  >51 publications with NOX4 and Lung Diseases
Organs/Tissues associated with anti-NOX4 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >284 publications with NOX4 and Muscle
 Heart Antibodies  >219 publications with NOX4 and Heart
 Kidney Antibodies  >186 publications with NOX4 and Kidney
 Lung Antibodies  >82 publications with NOX4 and Lung
 Brain Antibodies  >53 publications with NOX4 and Brain
 Liver Antibodies  >49 publications with NOX4 and Liver
 Connective Tissue Antibodies  >40 publications with NOX4 and Connective Tissue
 Eye Antibodies  >31 publications with NOX4 and Eye
 Embryonic Tissue Antibodies  >20 publications with NOX4 and Embryonic Tissue
 Bone Marrow Antibodies  >13 publications with NOX4 and Bone Marrow
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