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anti-NALP3 antibody :: Goat anti-Rat NALP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223850
Testing Data #1
Unit / Price
0.05 mg  /  $650 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NALP3, Polyclonal Antibody

 Also Known As   

GOAT ANTI HUMAN NALP3 (C-TERMINAL)

 Product Gene Name   

anti-NALP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120100
 3D Structure    ModBase 3D Structure for Q96P20
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 0.5mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
 Buffer Solution    TRIS buffered saline
 Antiserum Preparation    Antisera to human NALP3 were raised by repeated immunisation of goats with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-NALP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NALP3 antibody

   Goat anti Human NALP3 antibody recognizes human NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1 or Cryopyrin. NALP3 is a 1036 amino acid ~120kDa cytoplasmic protein belonging to the NLRP family, containing a single DAPIN domain, nine leucine-rich repeats and a single NACHT domain (UniProt: Q96P20). NALP3 is involved in inflammation and immune responses. NALP3 may function as an activator of NF-kappaB signalling and play a role in the regulation of inflammation and apoptosis (Choi and Ryter 2014). NALP3 is strongly expressed in polymorphonuclear cells, osteoblasts and chondrocytes, NALP3 can also be detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. Mutations in the NALP3 gene have been associated with familial cold autoinflammatory syndrome (Hoffman et al. 2001), Muckle-Wells syndrome (Dodé et al. 2002), chronic infantile neurological cutaneous and articular syndrome (Feldmann et al. 2002) and neonatal-onset multisystem inflammatory disease (Aksentijevich et al. 2002). Goat anti Human NALP3 antibody has been used successfuly for the detection of NALP3 in the eyes of rats by immunohistochemistry on formalin fixed, paraffin embedded sections (Liu et al. 2014).
 Applications Tested/Suitable for anti-NALP3 antibody   

ELISA (EIA), Immunohistology Paraffin*

 Application Notes for anti-NALP3 antibody    ELISA: Maximum Dilution: 1/32000;
Immunohistology - Paraffin: Maximum Dilution: 2.5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
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 Testing Data #1 of anti-NALP3 antibody    Staining of formalin fixed human peripheral blood leukocytes with Goat annti Human NALP3 (MBS223850)
anti-NALP3 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for NALP3. It may not necessarily be applicable to this product.
 NCBI GI #    119395764
 NCBI GeneID    114548
 NCBI Accession #    NP_001073289.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079821.2 [Other Products]
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 UniProt Primary Accession #    Q96P20 [Other Products]
 UniProt Secondary Accession #    O75434; Q17RS2; Q59H68; Q5JQS8; Q5JQS9; Q6TG35; Q8TCW0; B2RC97; B7ZKS9; B7ZKT2; B7ZKT3 [Other Products]
 UniProt Related Accession #    Q96P20 [Other Products]
 Molecular Weight    115,968 Da
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 NCBI Official Full Name    NACHT, LRR and PYD domains-containing protein 3 isoform a
 NCBI Official Synonym Full Names    NLR family, pyrin domain containing 3
 NCBI Official Symbol    NLRP3 [Similar Products]
 NCBI Official Synonym Symbols   
AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
[Similar Products]
 NCBI Protein Information    NACHT, LRR and PYD domains-containing protein 3; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; PYRIN-containing APAF1-like protein 1; caterpiller protein 1.1; cold autoinflammatory syndrome 1 protein; cryopyrin; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
 UniProt Protein Name    NACHT, LRR and PYD domains-containing protein 3
 UniProt Synonym Protein Names   
Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1
 UniProt Gene Name    NLRP3 [Similar Products]
 UniProt Synonym Gene Names    C1orf7; CIAS1; NALP3; PYPAF1; CLR1.1 [Similar Products]
 UniProt Entry Name    NALP3_HUMAN
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 NCBI Summary for NALP3    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
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 UniProt Comments for NALP3    NLRP3: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1); also known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS); also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs. Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA); also known as neonatal onset multisystem inflammatory disease (NOMID). CINCA is a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis and joint manifestations with recurrent fever and inflammation. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: cytoplasm; cytosol

Molecular Function: peptidoglycan binding; protein binding; ATP binding

Biological Process: caspase activation; apoptosis; negative regulation of acute inflammatory response; positive regulation of caspase activity; interleukin-1 beta production; defense response; positive regulation of interleukin-1 beta secretion; negative regulation of NF-kappaB import into nucleus; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of interleukin-1 beta secretion; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; interleukin-18 production; innate immune response; interleukin-1 secretion; detection of biotic stimulus; inflammatory response; defense response to virus

Disease: Cinca Syndrome; Familial Cold Autoinflammatory Syndrome 1; Muckle-wells Syndrome
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 Research Articles on NALP3    1. These findings demonstrate a role for the surface charge of particulates in the activation of the NLRP3 inflammasome, which should be considered when designing a novel vaccine formulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NALP3 antibodyDiseases associated with anti-NALP3 antibody
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >924 publications with NALP3 and Inflammation
 Death Antibodies  >238 publications with NALP3 and Death
 MUCKLE-WELLS SYNDROME Antibodies  >185 publications with NALP3 and MUCKLE-WELLS SYNDROME
 Necrosis Antibodies  >183 publications with NALP3 and Necrosis
 Cryopyrin-Associated Periodic Syndromes Antibodies  >138 publications with NALP3 and Cryopyrin-Associated Periodic Syndromes
 Autoimmune Diseases Antibodies  >138 publications with NALP3 and Autoimmune Diseases
 FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1 Antibodies  >136 publications with NALP3 and FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1
 Disease Models, Animal Antibodies  >114 publications with NALP3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >98 publications with NALP3 and Cardiovascular Diseases
 Lung Diseases Antibodies  >82 publications with NALP3 and Lung Diseases
Organs/Tissues associated with anti-NALP3 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >398 publications with NALP3 and Blood
 Lung Antibodies  >129 publications with NALP3 and Lung
 Bone Marrow Antibodies  >105 publications with NALP3 and Bone Marrow
 Brain Antibodies  >78 publications with NALP3 and Brain
 Intestine Antibodies  >33 publications with NALP3 and Intestine
 Connective Tissue Antibodies  >28 publications with NALP3 and Connective Tissue
 Pancreas Antibodies  >19 publications with NALP3 and Pancreas
 Thymus Antibodies  >3 publications with NALP3 and Thymus
 Prostate Antibodies  >2 publications with NALP3 and Prostate
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