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anti-NANOS1 antibody :: Goat NANOS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420894
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NANOS1, Polyclonal Antibody

 Also Known As   

Goat anti-NANOS1 Antibody

 Product Synonym Names    NANOS1; nanos homolog 1 (Drosophila); NOS1; nanos homolog 1; NANOS1 antibody; nanos homolog 1 (Drosophila) antibody; NOS1 antibody; nanos homolog 1 antibody
 Product Gene Name   

anti-NANOS1 antibody

[Similar Products]
 Antibody/Peptide Pairs    NANOS1 peptide (MBS426706) is used for blocking the activity of NANOS1 antibody (MBS420894)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SARDGPPGKK LR
 OMIM    608226
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SARDGPPGKKLR, from the C Terminus of the protein sequence according to NP_955631.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NANOS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NANOS1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-NANOS1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 35-37kDa band observed in Human Testis lysates (calculated MW of 30.2kDa according to NP_955631.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Clarke et al, Hum Mol Genet.2004 Apr 1;13(7): 727-39. Epub 2004 Feb 12, PMID: 14962983). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-NANOS1 antibody    (0.3ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-NANOS1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NANOS1. It may not necessarily be applicable to this product.
 NCBI GI #    40804761
 NCBI GeneID    340719
 NCBI Accession #    NP_955631.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199461.3 [Other Products]
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 UniProt Related Accession #    Q8WY41 [Other Products]
 Molecular Weight    30,230 Da
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 NCBI Official Full Name    nanos homolog 1
 NCBI Official Synonym Full Names    nanos homolog 1 (Drosophila)
 NCBI Official Symbol    NANOS1 [Similar Products]
 NCBI Official Synonym Symbols   
NOS1; NOS-1; SPGF12; EC_Rep1a
[Similar Products]
 NCBI Protein Information    nanos homolog 1
 UniProt Protein Name    Nanos homolog 1
 UniProt Synonym Protein Names   
EC_Rep1a
 Protein Family    Nanos
 UniProt Gene Name    NANOS1 [Similar Products]
 UniProt Synonym Gene Names    NOS1; NOS-1 [Similar Products]
 UniProt Entry Name    NANO1_HUMAN
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 NCBI Summary for NANOS1    This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
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 UniProt Comments for NANOS1    NANOS1: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Belongs to the nanos family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 10q26.11

Cellular Component: cytoplasm; perinuclear region of cytoplasm

Molecular Function: protein binding; RNA binding; translation repressor activity; zinc ion binding

Biological Process: cell migration; negative regulation of translation

Disease: Spermatogenic Failure 12
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 Research Articles on NANOS1    1. High NANOS expression is associated with retinoblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NANOS1 antibodyDiseases associated with anti-NANOS1 antibody
 Reference Product  PubMed Publications
 PUM2 antibody  >4 publications with NANOS1 and PUM2
 DAZL antibody  >3 publications with NANOS1 and DAZL
 DDX4 antibody  >2 publications with NANOS1 and DDX4
 MMP14 antibody  >1 publications with NANOS1 and MMP14
 Disease Name  Pubmed Publications
 Embryo Loss Antibodies  >2 publications with NANOS1 and Embryo Loss
 Oligospermia Antibodies  >2 publications with NANOS1 and Oligospermia
 Neoplasm Metastasis Antibodies  >1 publications with NANOS1 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >1 publications with NANOS1 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with NANOS1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with NANOS1 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with NANOS1 and Breast Neoplasms
Organs/Tissues associated with anti-NANOS1 antibody
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >7 publications with NANOS1 and Testis
 Brain Antibodies  >3 publications with NANOS1 and Brain
 Ovary Antibodies  >2 publications with NANOS1 and Ovary
 Muscle Antibodies  >2 publications with NANOS1 and Muscle
 Lung Antibodies  >2 publications with NANOS1 and Lung
 Heart Antibodies  >1 publications with NANOS1 and Heart
 Intestine Antibodies  >1 publications with NANOS1 and Intestine
 Liver Antibodies  >1 publications with NANOS1 and Liver
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