Q15080
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed MW: 40KDa Calculated MW: 39kDa
NCBI Official Full Name
Neutrophil cytosol factor 4
NCBI Official Synonym Full Names
neutrophil cytosolic factor 4, 40kDa
NCBI Protein Information
neutrophil cytosol factor 4; NCF-4; p40-phox; neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4
UniProt Protein Name
Neutrophil cytosol factor 4
UniProt Synonym Protein Names
Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phox
UniProt Synonym Gene Names
UniProt Entry Name
NCF4_HUMAN
NCBI Summary for NCF4
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for NCF4
p40phox: a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: membrane; endosome membrane; cytosol; NADPH oxidase complex
Molecular Function: protein dimerization activity; protein binding; superoxide-generating NADPH oxidase activator activity; phosphatidylinositol 3-phosphate binding
Biological Process: positive regulation of catalytic activity; interaction with host; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Iii
Research Articles on NCF4
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Products associated with anti-NCF4 antibody
Pathways associated with anti-NCF4 antibody
Organs/Tissues associated with anti-NCF4 antibody
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