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anti-NCK1 antibody :: Rabbit NCK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125034
Western Blot (WB)
Unit / Price
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCK1, Polyclonal Antibody

 Also Known As   

NCK1 Polyclonal Antibody

 Product Synonym Names    NCK; nck-1; NCKalpha
 Product Gene Name   

anti-NCK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600508
 3D Structure    ModBase 3D Structure for P16333
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human NCK1
 Calculated Molecular Weight    43kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-NCK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NCK1 antibody

   NCK family adaptor proteins function to couple tyrosine phosphorylation signals to regulate actin cytoskeletal reorganization that leads to cell motility. Cytoplasmic protein NCK1 (or NCK alpha) is an adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 binds a number of intracellular proteins and influences various signaling pathways including GTPase-activating protein of Ras (RasGAP), which is responsible for the down-regulation of Ras. NCK1 is recently reported to regulate the UPR, which secondary to obesity impairs glucose homeostasis and insulin actions.
 Product Categories/Family for anti-NCK1 antibody    Polyclonal
 Applications Tested/Suitable for anti-NCK1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NCK1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:20 - 1:50
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 Western Blot (WB) of anti-NCK1 antibody    Western blot analysis of extracts of Mouse brain, using NCK1 antibody.
anti-NCK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NCK1. It may not necessarily be applicable to this product.
 NCBI GI #    127962
 NCBI GeneID    4690
 NCBI Accession #    P16333.1 [Other Products]
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 UniProt Primary Accession #    P16333 [Other Products]
 UniProt Secondary Accession #    B7Z751; D3DNE3 [Other Products]
 UniProt Related Accession #    P16333 [Other Products]
 Molecular Weight    377
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 NCBI Official Full Name    Cytoplasmic protein NCK1
 NCBI Official Synonym Full Names    NCK adaptor protein 1
 NCBI Official Symbol    NCK1 [Similar Products]
 NCBI Official Synonym Symbols   
NCK; nck-1; NCKalpha
[Similar Products]
 NCBI Protein Information    cytoplasmic protein NCK1; NCK tyrosine kinase; melanoma NCK protein; SH2/SH3 adaptor protein NCK-alpha; non-catalytic region of tyrosine kinase
 UniProt Protein Name    Cytoplasmic protein NCK1
 UniProt Synonym Protein Names   
NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha
 Protein Family    Cytoplasmic protein
 UniProt Gene Name    NCK1 [Similar Products]
 UniProt Synonym Gene Names    NCK; Nck-1 [Similar Products]
 UniProt Entry Name    NCK1_HUMAN
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 NCBI Summary for NCK1    The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
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 UniProt Comments for NCK1    NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: endoplasmic reticulum; cytoplasm; plasma membrane; ribosome; protein phosphatase type 1 complex; intercellular junction; vesicle membrane; cytosol; nucleus

Molecular Function: protein binding, bridging; protein domain specific binding; protein binding; receptor signaling complex scaffold activity; protein kinase inhibitor activity; SH3/SH2 adaptor activity; cytoskeletal adaptor activity; receptor tyrosine kinase binding; receptor binding

Biological Process: lamellipodium biogenesis; axon guidance; positive regulation of translation in response to stress; T cell activation; negative regulation of peptidyl-serine phosphorylation; signal complex assembly; actin filament organization; response to other organism; T cell receptor signaling pathway; substrate-bound cell migration, cell extension; positive regulation of actin filament polymerization; negative regulation of protein kinase activity; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; vascular endothelial growth factor receptor signaling pathway
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 Research Articles on NCK1    1. the present study characterized a novel Nck-1-ELMO1 interaction and defined a new role for Nck-1 in regulating Rac1 activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to NCK1 Polyclonal Antibody
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 MBS7206183  Mouse Cytoplasmic protein NCK1 (NCK1) ELISA Kit  MBS2526233  NCK1 Polyclonal Antibody
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 MBS9402119  NCK1 antibody  MBS837447  NCK1/2 antibody
Products associated with anti-NCK1 antibodyPathways associated with anti-NCK1 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >2 publications with NCK1 and EGFR
 PDGFRB antibody  >2 publications with NCK1 and PDGFRB
 RASA1 antibody  >1 publications with NCK1 and RASA1
 PAK1 antibody  >1 publications with NCK1 and PAK1
 CBL antibody  >1 publications with NCK1 and CBL
 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
Diseases associated with anti-NCK1 antibodyOrgans/Tissues associated with anti-NCK1 antibody
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >5 publications with NCK1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >4 publications with NCK1 and Liver Diseases
 Breast Neoplasms Antibodies  >3 publications with NCK1 and Breast Neoplasms
 Kidney Diseases Antibodies  >2 publications with NCK1 and Kidney Diseases
 Hematologic Diseases Antibodies  >2 publications with NCK1 and Hematologic Diseases
 Nervous System Diseases Antibodies  >2 publications with NCK1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >2 publications with NCK1 and Neoplasm Metastasis
 Proteinuria Antibodies  >2 publications with NCK1 and Proteinuria
 Nerve Degeneration Antibodies  >1 publications with NCK1 and Nerve Degeneration
 Carcinoma, Squamous Cell Antibodies  >1 publications with NCK1 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with NCK1 and Eye
 Pancreas Antibodies  >1 publications with NCK1 and Pancreas
 Lung Antibodies  >1 publications with NCK1 and Lung
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