Q15788.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Nuclear receptor coactivator 1
NCBI Official Synonym Full Names
nuclear receptor coactivator 1
NCBI Official Synonym Symbols
SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74 [Similar Products]
NCBI Protein Information
nuclear receptor coactivator 1; Hin-2 protein; PAX3/NCOA1 fusion protein; steroid receptor coactivator-1; renal carcinoma antigen NY-REN-52; class E basic helix-loop-helix protein 74
UniProt Protein Name
Nuclear receptor coactivator 1
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 74; bHLHe74; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; SRC-1
UniProt Synonym Gene Names
UniProt Entry Name
NCOA1_HUMAN
NCBI Summary for NCOA1
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for NCOA1
SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described.
Protein type: DNA-binding; Acetyltransferase; Oncoprotein; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: nucleoplasm; neuron projection; nuclear chromatin; cytoplasm
Molecular Function: ligand-dependent nuclear receptor binding; protein dimerization activity; transcription coactivator activity; protein N-terminus binding; retinoid X receptor binding; signal transducer activity; protein binding; histone acetyltransferase activity; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; protein complex binding; estrogen receptor binding; chromatin binding; progesterone receptor binding; nuclear hormone receptor binding
Biological Process: lactation; hypothalamus development; positive regulation of transcription from RNA polymerase II promoter by galactose; male mating behavior; intracellular receptor-mediated signaling pathway; response to retinoic acid; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; male gonad development; hippocampus development; positive regulation of female receptivity; cellular lipid metabolic process; response to estradiol stimulus; cellular response to hormone stimulus; ovulation cycle; androgen receptor signaling pathway; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; response to progesterone stimulus
Research Articles on NCOA1
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Pathways associated with anti-NCOA1 antibody
Diseases associated with anti-NCOA1 antibody
Organs/Tissues associated with anti-NCOA1 antibody
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