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anti-NCOR1 antibody :: Rabbit anti-Human, Mouse NCOR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628541 anti-NCOR1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCOR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

NCOR1, NT (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047)

 Product Synonym Names    Anti -NCOR1, NT (Nuclear Receptor Co-repressor 1, N-CoR, KIAA1047)
 Product Gene Name   

anti-NCOR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (15933408..16118874, complement). Location: 17p11.2
 OMIM    600849
 3D Structure    ModBase 3D Structure for O75376
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes human NCOR1. Species Crossreactivity: mouse.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide corresponding to aa24-54 from the N-terminal region of human NCOR1, conjugated to KLH.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-NCOR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NCOR1 antibody

   NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
 Product Categories/Family for anti-NCOR1 antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-NCOR1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NCOR1 antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for NCOR1. It may not necessarily be applicable to this product.
 NCBI GI #    298919181
 NCBI GeneID    9611
 NCBI Accession #    NP_001177369.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190440.1 [Other Products]
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 UniProt Primary Accession #    O75376 [Other Products]
 UniProt Secondary Accession #    Q9UPV5; Q9UQ18; B3DLF8 [Other Products]
 UniProt Related Accession #    O75376; Q05CG3; Q3B773; Q6NTH1; Q6PDT8; Q6PGR4; Q7Z516; Q86W52; Q86YY0; Q86YY1 [Other Products]
 Molecular Weight    270,210 Da [Similar Products]
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 NCBI Official Full Name    nuclear receptor corepressor 1 isoform 3
 NCBI Official Synonym Full Names    nuclear receptor corepressor 1
 NCBI Official Symbol    NCOR1 [Similar Products]
 NCBI Official Synonym Symbols   
N-CoR; TRAC1; N-CoR1; hN-CoR; KIAA1047; MGC104216
[Similar Products]
 NCBI Protein Information    nuclear receptor corepressor 1; OTTHUMP00000065575; OTTHUMP00000065577; OTTHUMP00000065578; OTTHUMP00000065580; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1
 UniProt Protein Name    Nuclear receptor corepressor 1
 Protein Family    Nuclear receptor corepressor
 UniProt Gene Name    NCOR1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1047 [Similar Products]
 UniProt Entry Name    NCOR1_HUMAN
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 NCBI Summary for NCOR1    This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
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 UniProt Comments for NCOR1    N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; transcription factor complex; Sin3 complex; transcriptional repressor complex; membrane; spindle microtubule; cytoplasm; histone deacetylase complex; nuclear chromatin; nucleus

Molecular Function: retinoid X receptor binding; protein binding; histone deacetylase regulator activity; sequence-specific DNA binding; histone deacetylase binding; thyroid hormone receptor binding; chromatin binding; transcription corepressor activity; transcription factor activity; nuclear hormone receptor binding

Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; transcription initiation from RNA polymerase II promoter; negative regulation of JNK cascade; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; transcription, DNA-dependent; regulation of multicellular organism growth; thalamus development; chromatin modification; cellular lipid metabolic process; spindle assembly; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; cholesterol homeostasis; transforming growth factor beta receptor signaling pathway; gene expression; circadian regulation of gene expression; negative regulation of phosphoinositide 3-kinase cascade
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 Research Articles on NCOR1    1. data strongly support a model in which EBNA2 association with NCoR-deficient RBPJ enhances transcription and EBNALP dismisses NCoR and RBPJ repressive complexes from enhancers
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NCOR1 antibodyPathways associated with anti-NCOR1 antibody
 Reference Product  PubMed Publications
  antibody  > publications with NCOR1 and
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
Diseases associated with anti-NCOR1 antibodyOrgans/Tissues associated with anti-NCOR1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >106 publications with NCOR1 and Neoplasms
 Leukemia Antibodies  >36 publications with NCOR1 and Leukemia
 Skin Diseases Antibodies  >35 publications with NCOR1 and Skin Diseases
 Breast Neoplasms Antibodies  >35 publications with NCOR1 and Breast Neoplasms
 Leukemia, Myeloid Antibodies  >25 publications with NCOR1 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >24 publications with NCOR1 and Leukemia, Myeloid, Acute
 Carcinoma Antibodies  >19 publications with NCOR1 and Carcinoma
 Thyroid Neoplasms Antibodies  >17 publications with NCOR1 and Thyroid Neoplasms
 Leukemia, Promyelocytic, Acute Antibodies  >17 publications with NCOR1 and Leukemia, Promyelocytic, Acute
 Thyroid Diseases Antibodies  >15 publications with NCOR1 and Thyroid Diseases
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >147 publications with NCOR1 and Thyroid
 Liver Antibodies  >29 publications with NCOR1 and Liver
 Blood Antibodies  >26 publications with NCOR1 and Blood
 Brain Antibodies  >22 publications with NCOR1 and Brain
 Prostate Antibodies  >19 publications with NCOR1 and Prostate
 Kidney Antibodies  >15 publications with NCOR1 and Kidney
 Muscle Antibodies  >9 publications with NCOR1 and Muscle
 Uterus Antibodies  >8 publications with NCOR1 and Uterus
 Embryonic Tissue Antibodies  >7 publications with NCOR1 and Embryonic Tissue
 Bone Antibodies  >6 publications with NCOR1 and Bone
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