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anti-Slc8a3 antibody :: Rabbit anti-Rat NCX3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617198 anti-Slc8a3 antibody
Unit / Price
0.05 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCX3 (Slc8a3), Polyclonal Antibody

 Also Known As   

NCX3 (Sodium Calcium Exchanger)

 Product Synonym Names    Anti -NCX3 (Sodium Calcium Exchanger)
 Product Gene Name   

anti-Slc8a3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000078.5 (82298902..82434167, complement). Location: 12 D1; 12 41.0 cM
 3D Structure    ModBase 3D Structure for Q8R503
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Recognizes rat NCX3 (Sodium Calcium Exchanger). Does not have significant sequence homology with other NCX. Species sequence homology: mouse; 90%, human; 80%.
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid in PBS, 0.05% sodium azide.
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 Immunogen    Synthetic peptide corresponding to 20aa from rat NCX3 conjugated to KLH. Does not have significant sequence homology with other NCX. Species Sequence Homology: mouse; 90%, human; 80%.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-Slc8a3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Slc8a3 antibody

   Ca2+ plays a critical role in intracellular signaling. Intracellular Ca2+ levels are tightly controlled by continuos removal of Ca2+ via ATP-driven Ca2+ pump in the endoplasmic reticulum and plasma membrane, and Ca2+ transport system, the Na+/Ca2+ exchangers (NCX), in the plasma membrane. NCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In most cells, 3 Na+ are exchanged for 1 Ca2+. In mammals, at least 5 distinct genes code for the exchangers: Three NCX (NCX1, NCX2, and NCX3), and two in the NCKX family (NCKX1 and NCKX2). NCX share significant sequence homology (~70%), display 11 TM domains, a large central, intracellular hydrophilic regulatory loop between TM5 and 6, extracellular N-terminus and cytoplasmic C-terminus. The N-terminal signal peptide is cleaved off from the mature exchanger protein. NCX1 (rat 971aa, human 970aa, mouse 970aa) is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling, but is also present in most other tissues. Alternative spicing of NCX1/NACA1 produces numerous tissue specific isoforms (heart NACA1; Kidney NACA2, -3, and -7; brain NACA4-6). NCX2 (rat 921aa) is restricted to brain and skeletal muscle. NCX3 (rat 927aa) shares 73-75% with NCX1 and NCX2. NCX3 is also restricted to brain and muscle.
 Product Categories/Family for anti-Slc8a3 antibody    Antibodies; Abs to Ion Channel
 Applications Tested/Suitable for anti-Slc8a3 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-Slc8a3 antibody    Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
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NCBI/Uniprot data below describe general gene information for Slc8a3. It may not necessarily be applicable to this product.
 NCBI GI #    19168502
 NCBI GeneID    110893
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 UniProt Primary Accession #    Q8R503 [Other Products]
 UniProt Related Accession #    Q3UTP5; Q3UWJ8; Q7TS90; Q8BXN1; Q8R503; Q8VHJ8; Q9EPU8 [Other Products]
 Molecular Weight    10,282 Da [Similar Products]
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 NCBI Official Full Name    Na+/Ca2+ exchanger NCX3 isoform
 NCBI Official Synonym Full Names    solute carrier family 8 (sodium/calcium exchanger), member 3
 NCBI Official Symbol    Slc8a3 [Similar Products]
 NCBI Official Synonym Symbols   
Ncx3; AW742262; MGC90626
[Similar Products]
 NCBI Protein Information    solute carrier family 8 (sodium/calcium exchanger), member 3; solute carrier family 8 (sodium/calcium exchanger), member 3
 UniProt Protein Name    Na+/Ca2+ exchanger NCX3 isoform
 Protein Family    Sodium/calcium exchanger
 UniProt Gene Name    Slc8a3 [Similar Products]
 UniProt Synonym Gene Names    NCX3 [Similar Products]
 UniProt Entry Name    Q8R503_MOUSE
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 UniProt Comments for Slc8a3    SLC8A3: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Cellular Component: microtubule; cell projection; cell soma; mitochondrion; integral to plasma membrane; dendritic spine; plasma membrane; cytosol; sarcolemma

Molecular Function: calcium:cation antiporter activity; calcium:sodium antiporter activity

Biological Process: metal ion transport; sodium ion transport; hemopoietic progenitor cell differentiation
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 Research Articles on Slc8a3    1. The deletion of the NCX3 gene has detrimental consequences on basal synaptic transmission, long term potentiation regulation, spatial learning, and memory performance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Slc8a3 antibodyOrgans/Tissues associated with anti-Slc8a3 antibody
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 Platelet Calcium Homeostasis Pathway antibodies  Platelet Calcium Homeostasis Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with Slc8a3 and Brain
 Spinal Cord Antibodies  >2 publications with Slc8a3 and Spinal Cord
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