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anti-NCoA-3 antibody :: Rabbit NCoA-3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2538228
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCoA-3, Polyclonal Antibody

 Also Known As   

NCoA-3 Polyclonal Antibody

 Product Synonym Names    NCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1
 Product Gene Name   

anti-NCoA-3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the Internal region of human NCoA-3.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.1539% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NCoA-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NCoA-3 antibody    Cancer
 Applications Tested/Suitable for anti-NCoA-3 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-NCoA-3 antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-NCoA-3 antibody    Western Blot analysis of Hela, HepG2 cells with NCoA-3 Polyclonal Antibody.
anti-NCoA-3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NCoA-3 antibody    Immunohistochemistry of paraffin-embedded Mouse brain tissue using NCoA-3 Polyclonal Antibody at dilution of 1:100.
anti-NCoA-3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NCoA-3. It may not necessarily be applicable to this product.
 NCBI GI #    118026946
 NCBI GeneID    17979
 NCBI Accession #    NP_032705.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008679.3 [Other Products]
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 UniProt Secondary Accession #    Q9CRD5 [Other Products]
 UniProt Related Accession #    O09000 [Other Products]
 Molecular Weight    Calculated MW: 155
Observed MW: 160
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 NCBI Official Full Name    nuclear receptor coactivator 3
 NCBI Official Synonym Full Names    nuclear receptor coactivator 3
 NCBI Official Symbol    Ncoa3 [Similar Products]
 NCBI Official Synonym Symbols   
Actr; Aib1; Rac3; Src3; pCip; Tram1; p/Cip; KAT13B; Tram-1; bHLHe42; AW321064; 2010305B15Rik
[Similar Products]
 NCBI Protein Information    nuclear receptor coactivator 3
 UniProt Protein Name    Nuclear receptor coactivator 3
 UniProt Synonym Protein Names   
Amplified in breast cancer-1 protein homolog; AIB-1; CBP-interacting protein; p/CIP; pCIP; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; ACTR; TRAM-1
 UniProt Gene Name    Ncoa3 [Similar Products]
 UniProt Synonym Gene Names    Aib1; Pcip; Rac3; Tram1; NCoA-3; AIB-1; p/CIP; pCIP; RAC-3; SRC-3; ACTR; TRAM-1 [Similar Products]
 UniProt Entry Name    NCOA3_MOUSE
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 UniProt Comments for NCoA-3    SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: Acetyltransferase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; EC; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; Golgi apparatus; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: androgen receptor binding; chromatin binding; estrogen receptor binding; histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; peroxisome proliferator activated receptor binding; protein binding; protein complex binding; protein dimerization activity; protein N-terminus binding; transcription coactivator activity; transferase activity; transferase activity, transferring acyl groups

Biological Process: cellular response to hormone stimulus; developmental growth; histone acetylation; multicellular organism growth; negative regulation of apoptosis; positive regulation of cell growth; positive regulation of estrogen receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of steroid hormone receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; vagina development
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 Research Articles on NCoA-3    1. SRC-3 is a target for inhibiting aggressive prostate cancer containing neuroendocrine tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NCoA-3 antibodyPathways associated with anti-NCoA-3 antibody
 Reference Product  PubMed Publications
 Crebbp antibody  >23 publications with NCoA-3 and Crebbp
 Carm1 antibody  >13 publications with NCoA-3 and Carm1
 Ncor1 antibody  >11 publications with NCoA-3 and Ncor1
 Ncor2 antibody  >10 publications with NCoA-3 and Ncor2
 Ep300 antibody  >8 publications with NCoA-3 and Ep300
 Ppargc1a antibody  >2 publications with NCoA-3 and Ppargc1a
 Med1 antibody  >2 publications with NCoA-3 and Med1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 MAPK Family Signaling Cascades Pathway antibodies  MAPK Family Signaling Cascades Pathway Diagram
 MAPK6/MAPK4 Signaling Pathway antibodies  MAPK6/MAPK4 Signaling Pathway Diagram
 Mus Musculus Biological Processes Pathway antibodies  Mus Musculus Biological Processes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
 Transcriptional Regulation Of Adipocyte Differentiation In 3T3-L1 Pre-adipocytes Pathway antibodies  Transcriptional Regulation Of Adipocyte Differentiation In 3T3-L1 Pre-adipocytes Pathway Diagram
Organs/Tissues associated with anti-NCoA-3 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with NCoA-3 and Blood
 Prostate Antibodies  >31 publications with NCoA-3 and Prostate
 Liver Antibodies  >30 publications with NCoA-3 and Liver
 Thyroid Antibodies  >22 publications with NCoA-3 and Thyroid
 Lymph Node Antibodies  >19 publications with NCoA-3 and Lymph Node
 Lung Antibodies  >17 publications with NCoA-3 and Lung
 Brain Antibodies  >16 publications with NCoA-3 and Brain
 Muscle Antibodies  >16 publications with NCoA-3 and Muscle
 Mammary Gland Antibodies  >14 publications with NCoA-3 and Mammary Gland
 Bone Antibodies  >13 publications with NCoA-3 and Bone
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