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anti-NEBL antibody :: Goat NEBL/nebulette Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421779 anti-NEBL antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NEBL/nebulette, Polyclonal Antibody

 Also Known As   

Goat anti-NEBL/nebulette Antibody

 Product Synonym Names    NEBL; nebulette; FLJ53769; LNEBL; MGC119746; MGC119747; bA56H7.1; LIM-nebulette; NEBL, actin-binding Z-disc protein; OTTHUMP00000019268; actin-binding Z-disk protein; NEBL antibody; nebulette antibody; FLJ53769 antibody; LNEBL antibody; MGC119746 antibody; MGC119747 antibody; bA56H7.1 antibody; LIM-nebulette antibody; NEBL; actin-binding Z-disc protein antibody; OTTHUMP00000019268 antibody; actin-binding Z-disk protein antibody; Nebulette; NEBL / nebulette
 Product Gene Name   

anti-NEBL antibody

[Similar Products]
 Antibody/Peptide Pairs    NEBL / nebulette peptide (MBS425545) is used for blocking the activity of NEBL/nebulette antibody (MBS421779)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ELQRLKRTQE
 OMIM    605491
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ELQRLKRTQE, from the internal region of the protein sequence according to NP_998734.1; NP_001166955.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize isoform 2 and isoform 3 (NP_998734.1; NP_001166955.1) only, but does not recognize isoform 1 (NP_006384.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NEBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NEBL antibody   

Peptide ELISA (EIA)

 Application Notes for anti-NEBL antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 30kDa band in Human Brain (Frontal Cortex) lysates, but not in Human, Mouse and Rat Heart lysates after 1ug/ml antibody staining. This protein has a calculated MW of 31.2kDa according to NP_998734.1. The 30kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for NEBL. It may not necessarily be applicable to this product.
 NCBI GI #    47087157
 NCBI GeneID    10529
 NCBI Accession #    NP_998734.1 [Other Products]
 NCBI Related Accession #    NP_001166955.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_213569.2 [Other Products]
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 UniProt Secondary Accession #    Q2TBD0; Q70I54; Q9UIC4; B0YJ45 [Other Products]
 UniProt Related Accession #    O76041 [Other Products]
 Molecular Weight    31,196 Da
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 NCBI Official Full Name    nebulette isoform 2
 NCBI Official Synonym Full Names    nebulette
 NCBI Official Symbol    NEBL [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    nebulette
 UniProt Protein Name    Nebulette
 UniProt Synonym Protein Names   
Actin-binding Z-disk protein
 Protein Family    Nebulette
 UniProt Gene Name    NEBL [Similar Products]
 UniProt Synonym Gene Names    LNEBL [Similar Products]
 UniProt Entry Name    NEBL_HUMAN
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 NCBI Summary for NEBL    This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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 UniProt Comments for NEBL    NEBL: Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: I band; stress fiber; Z disc

Molecular Function: actin filament binding; cytoskeletal protein binding; filamin binding; protein binding; structural constituent of muscle; tropomyosin binding
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 Research Articles on NEBL    1. predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL common variants in the chromosome 10p13 linkage region
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NEBL antibodyDiseases associated with anti-NEBL antibody
 Reference Product  PubMed Publications
 XIRP2 antibody  >2 publications with NEBL and XIRP2
 HAND2 antibody  >2 publications with NEBL and HAND2
 XIRP1 antibody  >1 publications with NEBL and XIRP1
 ACTB antibody  >1 publications with NEBL and ACTB
 ZYX antibody  >1 publications with NEBL and ZYX
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with NEBL and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with NEBL and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >2 publications with NEBL and Cell Transformation, Neoplastic
 Inflammation Antibodies  >2 publications with NEBL and Inflammation
 Skin Diseases Antibodies  >2 publications with NEBL and Skin Diseases
 Kidney Diseases Antibodies  >2 publications with NEBL and Kidney Diseases
 Adenocarcinoma Antibodies  >1 publications with NEBL and Adenocarcinoma
 Hypertension Antibodies  >1 publications with NEBL and Hypertension
 Lung Diseases Antibodies  >1 publications with NEBL and Lung Diseases
 Hypertrophy Antibodies  >1 publications with NEBL and Hypertrophy
Organs/Tissues associated with anti-NEBL antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >31 publications with NEBL and Muscle
 Heart Antibodies  >20 publications with NEBL and Heart
 Embryonic Tissue Antibodies  >10 publications with NEBL and Embryonic Tissue
 Kidney Antibodies  >5 publications with NEBL and Kidney
 Skin Antibodies  >3 publications with NEBL and Skin
 Liver Antibodies  >2 publications with NEBL and Liver
 Eye Antibodies  >2 publications with NEBL and Eye
 Nerve Antibodies  >2 publications with NEBL and Nerve
 Brain Antibodies  >2 publications with NEBL and Brain
 Mouth Antibodies  >1 publications with NEBL and Mouth
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