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anti-NEDD9 antibody :: Goat NEDD9 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420844
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NEDD9, Polyclonal Antibody

 Also Known As   

Goat anti-NEDD9 Antibody

 Product Synonym Names    NEDD9; neural precursor cell expressed, developmentally down-regulated 9; CAS-L; CASL; HEF1; dJ49G10.2; dJ761I2.1; Crk-associated substrate related; cas-like docking dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); dJ761I2.1 (enhancer of filamentation (HEF; NEDD9 antibody; neural precursor cell expressed; developmentally down-regulated 9 antibody; CAS-L antibody; CASL antibody; HEF1 antibody; dJ49G10.2 antibody; dJ761I2.1 antibody; Crk-associated substrate related antibody; cas-like docking dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)) antibody; dJ761I2.1 (enhancer of filamentation (HEF1)) antibody; enhancer of filamentation 1 antibody
 Product Gene Name   

anti-NEDD9 antibody

[Similar Products]
 Antibody/Peptide Pairs    NEDD9 peptide (MBS425692) is used for blocking the activity of NEDD9 antibody (MBS420844)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NKPQNKCDDL DR
 OMIM    602265
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence NKPQNKCDDLDR, from the internal region of the protein sequence according to NP_006394.1; NP_892011.2.
 Epitope    Internal region
 Note    This antibody is expected to recognise isoform 1 (NP_006394.1) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NEDD9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NEDD9 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-NEDD9 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 100kDa band observed in Human Kidney, Lung and Placenta lysates (calculated MW of 92.9kDa according to NP_006394.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-NEDD9 antibody    (0.1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-NEDD9 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NEDD9. It may not necessarily be applicable to this product.
 NCBI GI #    5453680
 NCBI GeneID    4739
 NCBI Accession #    NP_006394.1 [Other Products]
 NCBI Related Accession #    NP_892011.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006403.3 [Other Products]
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 UniProt Secondary Accession #    Q5T9R4; Q5XKI0; A8K9G7; A8MSJ9; G5E9Y9 [Other Products]
 UniProt Related Accession #    Q14511 [Other Products]
 Molecular Weight    92,885 Da
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 NCBI Official Full Name    enhancer of filamentation 1 isoform 1
 NCBI Official Synonym Full Names    neural precursor cell expressed, developmentally down-regulated 9
 NCBI Official Symbol    NEDD9 [Similar Products]
 NCBI Official Synonym Symbols   
CAS2; CASL; HEF1; CAS-L; CASS2
[Similar Products]
 NCBI Protein Information    enhancer of filamentation 1
 UniProt Protein Name    Enhancer of filamentation 1
 UniProt Synonym Protein Names   
CRK-associated substrate-related protein; CAS-L; CasL
 Protein Family    Enhancer of filamentation
 UniProt Gene Name    NEDD9 [Similar Products]
 UniProt Synonym Gene Names    CASL; CASS2; hEF1; CAS-L; CasL; NEDD-9 [Similar Products]
 UniProt Entry Name    CASL_HUMAN
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 NCBI Summary for NEDD9    The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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 UniProt Comments for NEDD9    Cas-L: a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6p24.2

Cellular Component: cell cortex; cytoplasm; focal adhesion; Golgi apparatus; lamellipodium; nucleus; spindle; spindle pole

Molecular Function: protein binding

Biological Process: actin filament bundle formation; cell adhesion; cell division; cytoskeleton organization and biogenesis; integrin-mediated signaling pathway; mitosis; regulation of growth; signal transduction
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 Research Articles on NEDD9    1. Serum NEDD9 was elevated in gastric cancer patients and had an unfavorable prognostic effect.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NEDD9 antibodyPathways associated with anti-NEDD9 antibody
 Reference Product  PubMed Publications
 CRK antibody  >60 publications with NEDD9 and CRK
 SRC antibody  >44 publications with NEDD9 and SRC
 PTK2 antibody  >19 publications with NEDD9 and PTK2
 AURKA antibody  >13 publications with NEDD9 and AURKA
 FYN antibody  >6 publications with NEDD9 and FYN
 CRKL antibody  >6 publications with NEDD9 and CRKL
 SMAD3 antibody  >4 publications with NEDD9 and SMAD3
 LCK antibody  >2 publications with NEDD9 and LCK
 PTPN11 antibody  >1 publications with NEDD9 and PTPN11
 ABL1 antibody  >1 publications with NEDD9 and ABL1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-NEDD9 antibodyOrgans/Tissues associated with anti-NEDD9 antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >37 publications with NEDD9 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >25 publications with NEDD9 and Breast Neoplasms
 Lung Neoplasms Antibodies  >22 publications with NEDD9 and Lung Neoplasms
 Adenocarcinoma Antibodies  >20 publications with NEDD9 and Adenocarcinoma
 Lung Diseases Antibodies  >18 publications with NEDD9 and Lung Diseases
 Neoplasms, Experimental Antibodies  >10 publications with NEDD9 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >10 publications with NEDD9 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >6 publications with NEDD9 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >6 publications with NEDD9 and Liver Neoplasms
 Kidney Diseases Antibodies  >6 publications with NEDD9 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with NEDD9 and Blood
 Lung Antibodies  >30 publications with NEDD9 and Lung
 Lymph Node Antibodies  >14 publications with NEDD9 and Lymph Node
 Lymph Antibodies  >14 publications with NEDD9 and Lymph
 Brain Antibodies  >14 publications with NEDD9 and Brain
 Bone Antibodies  >9 publications with NEDD9 and Bone
 Liver Antibodies  >9 publications with NEDD9 and Liver
 Nerve Antibodies  >8 publications with NEDD9 and Nerve
 Kidney Antibodies  >8 publications with NEDD9 and Kidney
 Vascular Antibodies  >8 publications with NEDD9 and Vascular
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