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anti-Nrxn1 antibody :: Goat NEUREXIN 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622173 anti-Nrxn1 antibody
Unit / Price
0.1 mg  /  $560 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NEUREXIN 1 (Nrxn1), Polyclonal Antibody

 Also Known As   

NEUREXIN 1 (CT) (NRXN1, DKFZp313P2036, FLJ35941, Hs.22998, KIAA0578, Neurexin-1-alpha precursor, Neurexin-1-beta precursor, Neurexin I-alpha, Neurexin I-beta)

 Product Synonym Names    Anti -NEUREXIN 1 (CT) (NRXN1, DKFZp313P2036, FLJ35941, Hs.22998, KIAA0578, Neurexin-1-alpha precursor, Neurexin-1-beta precursor, Neurexin I-alpha, Neurexin I-beta)
 Product Gene Name   

anti-Nrxn1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_005105.2 (14050929..15354069, complement). Location: 6q12
 3D Structure    ModBase 3D Structure for Q63372
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Canine, Human, Mouse, Rat
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 Specificity    Recognizes an epitope within the CT region of human Neurexin 1 in cerebellum cell lysates at ~150kD. Species crossreactivity: Expected to react with Mouse, rat, and canine.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in TBS, pH 7.3, 0.02% sodium azide, 0.5% BSA.
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 Immunogen    Peptide sequence C-KEKQPSSAKSSNKN from the C-Terminal region of NRXN1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Nrxn1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Nrxn1 antibody

   Neurexin 1 (NRXN1) is a transmembrane neuronal protein and member of the neurexin family, which act as cell adhesion molecules and receptors within the vertebrate nervous system.
 Product Categories/Family for anti-Nrxn1 antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-Nrxn1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-Nrxn1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32000
Western Blot: 0.05-0.1ug/ml
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NCBI/Uniprot data below describe general gene information for Nrxn1. It may not necessarily be applicable to this product.
 NCBI GI #    37620151
 NCBI GeneID    60391
 NCBI Accession #    NP_068535.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021767.2 [Other Products]
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 UniProt Primary Accession #    Q63372 [Other Products]
 UniProt Related Accession #    Q63372; Q63373 [Other Products]
 Molecular Weight    167,923 Da [Similar Products]
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 NCBI Official Full Name    neurexin 1
 NCBI Official Synonym Full Names    neurexin 1
 NCBI Official Symbol    Nrxn1 [Similar Products]
 NCBI Official Synonym Symbols   
Nrxn1b
[Similar Products]
 NCBI Protein Information    neurexin 1; neurexin I-beta; neurexin-1-beta; neurexin I-alpha; neurexin-1-alpha; non-processed neurexin I-alpha
 UniProt Protein Name    Neurexin-1-alpha
 UniProt Synonym Protein Names   
Neurexin I-alpha
 Protein Family    Neurexin
 UniProt Gene Name    Nrxn1 [Similar Products]
 UniProt Entry Name    NRX1A_RAT
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 NCBI Summary for Nrxn1    neuronal cell recognition molecule; may have a role in synaptogenesis [RGD]
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 UniProt Comments for Nrxn1    NRXN1: Cell surface protein involved in cell-cell-interactions, excytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latroxin from spider venom. Belongs to the neurexin family. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: presynaptic membrane; cell surface; endocytic vesicle; cell; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding; calcium channel regulator activity; acetylcholine receptor binding; calcium ion binding; cell adhesion molecule binding; calcium-dependent protein binding; receptor binding

Biological Process: prepulse inhibition; neurotransmitter secretion; social behavior; vocal learning; learning; positive regulation of synaptic transmission, glutamatergic; cerebellar granule cell differentiation; negative regulation of filopodium formation; heterophilic cell adhesion; synaptic transmission; positive regulation of synaptogenesis; establishment of protein localization; synaptogenesis; adult behavior; calcium-dependent cell-cell adhesion; protein heterotetramerization; neuron adhesion; angiogenesis; cell adhesion; neuromuscular process controlling balance; vesicle docking during exocytosis
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 Research Articles on Nrxn1    1. Neurexin-1 is involved in the formation of the slit diaphragm of the glomerular podocytes in the kidney, and the maintenance of its function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Nrxn1 antibodyPathways associated with anti-Nrxn1 antibody
 Reference Product  PubMed Publications
 Nlgn3 antibody  >6 publications with Nrxn1 and Nlgn3
 Nlgn1 antibody  >3 publications with Nrxn1 and Nlgn1
 Apba2 antibody  >3 publications with Nrxn1 and Apba2
 Nlgn2 antibody  >2 publications with Nrxn1 and Nlgn2
 Cask antibody  >2 publications with Nrxn1 and Cask
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-Nrxn1 antibodyOrgans/Tissues associated with anti-Nrxn1 antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >34 publications with Nrxn1 and Schizophrenia
 Autistic Disorder Antibodies  >20 publications with Nrxn1 and Autistic Disorder
 Child Development Disorders, Pervasive Antibodies  >20 publications with Nrxn1 and Child Development Disorders, Pervasive
 Mental Retardation Antibodies  >13 publications with Nrxn1 and Mental Retardation
 Abnormalities, Multiple Antibodies  >4 publications with Nrxn1 and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >2 publications with Nrxn1 and Congenital Abnormalities
 Anxiety Disorders Antibodies  >2 publications with Nrxn1 and Anxiety Disorders
 Endometriosis Antibodies  >1 publications with Nrxn1 and Endometriosis
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with Nrxn1 and Prenatal Exposure Delayed Effects
 Craniofacial Abnormalities Antibodies  >1 publications with Nrxn1 and Craniofacial Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with Nrxn1 and Brain
 Embryonic Tissue Antibodies  >1 publications with Nrxn1 and Embryonic Tissue
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