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anti-NPY1R antibody :: Sheep anti-Rat NEUROPEPTIDE Y RECEPTOR 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221023
Testing Data #1
Unit / Price
1 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NEUROPEPTIDE Y RECEPTOR 1 (NPY1R), Polyclonal Antibody

 Also Known As   

SHEEP ANTI HUMAN NEUROPEPTIDE Y RECEPTOR 1

 Product Gene Name   

anti-NPY1R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162641
 3D Structure    ModBase 3D Structure for P25929
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
 Species Reactivity    Rat
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 Specificity    This item is specific for human neuropeptide Y receptor 1. Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 5.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    A synthetic peptide corresponding to amino acids 365 - 378 of human NPY1R, conjugated to KLH.Peptide sequence: KQASPVAFKKINNN
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-NPY1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NPY1R antibody

   MBS221023 is specific for human neuropeptide Y receptor 1. Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
 Applications Tested/Suitable for anti-NPY1R antibody   

ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-NPY1R antibody    Western Blot: This item detects a band of approximately 55 kDa in human brain.
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 1/100; Maximum Dilution: 1/1000
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 Testing Data #1 of anti-NPY1R antibody    Human brain lysate probed with Sheep anti Human Neuropeptide Y Receptor 1 (MBS221023)
anti-NPY1R antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for NPY1R. It may not necessarily be applicable to this product.
 NCBI GI #    4505445
 NCBI GeneID    4886
 NCBI Accession #    NP_000900.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000909.5 [Other Products]
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 UniProt Primary Accession #    P25929 [Other Products]
 UniProt Secondary Accession #    B2R6H5 [Other Products]
 UniProt Related Accession #    P25929 [Other Products]
 Molecular Weight    44,392 Da [Similar Products]
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 NCBI Official Full Name    neuropeptide Y receptor type 1
 NCBI Official Synonym Full Names    neuropeptide Y receptor Y1
 NCBI Official Symbol    NPY1R [Similar Products]
 NCBI Official Synonym Symbols   
NPYR; NPY1-R
[Similar Products]
 NCBI Protein Information    neuropeptide Y receptor type 1
 UniProt Protein Name    Neuropeptide Y receptor type 1
 Protein Family    Neuropeptide Y receptor
 UniProt Gene Name    NPY1R [Similar Products]
 UniProt Synonym Gene Names    NPYR; NPYY1; NPY1-R [Similar Products]
 UniProt Entry Name    NPY1R_HUMAN
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 NCBI Summary for NPY1R    This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
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 UniProt Comments for NPY1R    NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31.3-q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain
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 Research Articles on NPY1R    1. Y1R expression in visceral adipose tissue might be an indicator of increased risk of metabolic syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NPY1R antibodyPathways associated with anti-NPY1R antibody
 Reference Product  PubMed Publications
 NPY antibody  >59 publications with NPY1R and NPY
 NPY5R antibody  >17 publications with NPY1R and NPY5R
 PYY antibody  >3 publications with NPY1R and PYY
 POMC antibody  >1 publications with NPY1R and POMC
 GAL antibody  >1 publications with NPY1R and GAL
 PPY antibody  >1 publications with NPY1R and PPY
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-NPY1R antibodyOrgans/Tissues associated with anti-NPY1R antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with NPY1R and Nervous System Diseases
 Brain Diseases Antibodies  >10 publications with NPY1R and Brain Diseases
 Obesity Antibodies  >9 publications with NPY1R and Obesity
 Cardiovascular Diseases Antibodies  >8 publications with NPY1R and Cardiovascular Diseases
 Hypertension Antibodies  >6 publications with NPY1R and Hypertension
 Anxiety Disorders Antibodies  >6 publications with NPY1R and Anxiety Disorders
 Seizures Antibodies  >4 publications with NPY1R and Seizures
 Disease Models, Animal Antibodies  >4 publications with NPY1R and Disease Models, Animal
 Learning Disorders Antibodies  >3 publications with NPY1R and Learning Disorders
 Inflammation Antibodies  >2 publications with NPY1R and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >44 publications with NPY1R and Brain
 Vascular Antibodies  >8 publications with NPY1R and Vascular
 Heart Antibodies  >6 publications with NPY1R and Heart
 Connective Tissue Antibodies  >4 publications with NPY1R and Connective Tissue
 Kidney Antibodies  >3 publications with NPY1R and Kidney
 Intestine Antibodies  >3 publications with NPY1R and Intestine
 Bone Antibodies  >2 publications with NPY1R and Bone
 Liver Antibodies  >2 publications with NPY1R and Liver
 Spleen Antibodies  >1 publications with NPY1R and Spleen
 Ovary Antibodies  >1 publications with NPY1R and Ovary
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