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anti-NF2 antibody :: Rabbit anti-Human, Mouse NF2 / Merlin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240545
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NF2 / Merlin, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human NF2 / Merlin

 Product Synonym Names    Anti-NF2 / Merlin Antibody (phospho-Ser518) IHC-plus; NF2; ACN; BANF; Moesin-ezrin-radixin like; Neurofibromin 2 (merlin); Neurofibromin-2; SCH; Merlin; Schwannomerlin; Schwannomin; Human NF2; Merlin
 Product Gene Name   

anti-NF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 607379
 3D Structure    ModBase 3D Structure for P35240
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Human NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to Keyhole Limpet Hemocyanin (KLH).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Antigen Modification    pSer518
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 Preparation and Storage    Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-NF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NF2 antibody

   Mutations linked to neurofibromatosis type 2 led to the identification of NF2. NF2 encodes a protein related to the cytoskeletal components moesin, ezrin, and radixin, and was thus named merlin.
 Applications Tested/Suitable for anti-NF2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

 Application Notes for anti-NF2 antibody    ELISA, IHC-P (2.5 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-NF2 antibody    Anti-NF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-NF2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-NF2 antibody    Anti-Human NF2 (Merlin) pS518 Antibody - Western Blot. Affinity purified phospho-specific antibody to NF2 (Merlin) at pS518 was used at a 1:1000 dilution to detect NF2 by Western blot. Approximately 12 ul of a mouse cardiac myocyte lysate was loaded per lane on a 4-20% Criterion gel for SDS-PAGE. Samples were either mock treated (lane 1) or CLA treated at 4nM, 20 nM or 100 nM (lanes 2, 3 and 4 respectively) for 45. After washing, a 1:5000 dilution of HRP conjugated Gt-a-Rabbit IgG preceded color development using Amershams substrate system. Other detection methods will yield similar results.
anti-NF2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NF2. It may not necessarily be applicable to this product.
 NCBI GI #    4557795
 NCBI GeneID    4771
 NCBI Accession #    NP_000259.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000268.3 [Other Products]
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 UniProt Primary Accession #    P35240 [Other Products]
 UniProt Secondary Accession #    O95683; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3 [Other Products]
 UniProt Related Accession #    P35240 [Other Products]
 Molecular Weight    24,515 Da
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 NCBI Official Full Name    merlin isoform 1
 NCBI Official Synonym Full Names    neurofibromin 2 (merlin)
 NCBI Official Symbol    NF2 [Similar Products]
 NCBI Official Synonym Symbols   
ACN; SCH; BANF
[Similar Products]
 NCBI Protein Information    merlin; schwannomin; schwannomerlin; neurofibromin-2; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma)
 UniProt Protein Name    Merlin
 UniProt Synonym Protein Names   
Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin
 Protein Family    Merlin
 UniProt Gene Name    NF2 [Similar Products]
 UniProt Synonym Gene Names    SCH [Similar Products]
 UniProt Entry Name    MERL_HUMAN
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 NCBI Summary for NF2    This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NF2    Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Tumor suppressor

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; adherens junction; cytoskeleton; extrinsic to membrane; membrane; lamellipodium; perinuclear region of cytoplasm; apical part of cell; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow

Molecular Function: protein binding; actin binding

Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; Schwann cell proliferation; negative regulation of cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; positive regulation of cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of cell migration

Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
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 Research Articles on NF2    1. Study shows that overexpression of wild-type merlin inhibits cell proliferation, migration and adhesion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NF2 antibodyDiseases associated with anti-NF2 antibody
 Products by Pathway  Pathway Diagram
 ErbB2/ErbB3 Signaling Events Pathway antibodies  ErbB2/ErbB3 Signaling Events Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >928 publications with NF2 and Nervous System Diseases
 Neurofibromatosis 2 Antibodies  >848 publications with NF2 and Neurofibromatosis 2
 Meningioma Antibodies  >283 publications with NF2 and Meningioma
 Schwannomatosis Antibodies  >92 publications with NF2 and Schwannomatosis
 Mesothelioma Antibodies  >67 publications with NF2 and Mesothelioma
 Meningioma, familial Antibodies  >56 publications with NF2 and Meningioma, familial
 Eye Diseases Antibodies  >51 publications with NF2 and Eye Diseases
 Carcinoma Antibodies  >45 publications with NF2 and Carcinoma
 Lung Neoplasms Antibodies  >26 publications with NF2 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >22 publications with NF2 and Cardiovascular Diseases
Organs/Tissues associated with anti-NF2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >308 publications with NF2 and Brain
 Skin Antibodies  >70 publications with NF2 and Skin
 Eye Antibodies  >48 publications with NF2 and Eye
 Lung Antibodies  >40 publications with NF2 and Lung
 Bone Antibodies  >39 publications with NF2 and Bone
 Vascular Antibodies  >31 publications with NF2 and Vascular
 Muscle Antibodies  >30 publications with NF2 and Muscle
 Liver Antibodies  >19 publications with NF2 and Liver
 Kidney Antibodies  >16 publications with NF2 and Kidney
 Prostate Antibodies  >11 publications with NF2 and Prostate
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