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anti-NFASC antibody :: Rabbit NFASC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126436
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFASC, Polyclonal Antibody

 Also Known As   

NFASC Polyclonal Antibody

 Product Synonym Names    NF; NRCAML
 Product Gene Name   

anti-NFASC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609145
 3D Structure    ModBase 3D Structure for O94856
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic peptide of human NFASC
 Calculated Molecular Weight    150kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-NFASC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NFASC antibody

   This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
 Product Categories/Family for anti-NFASC antibody    Polyclonal
 Applications Tested/Suitable for anti-NFASC antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NFASC antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
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 Western Blot (WB) of anti-NFASC antibody    Western blot analysis of extracts of A549 cell lysate, using NFASC antibody.
anti-NFASC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-NFASC antibody    Immunohistochemistry of paraffin-embedded Human brain tissue using NFASC antibody.
anti-NFASC antibody Immunohistochemistry (IHC (IHC) image
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NCBI/Uniprot data below describe general gene information for NFASC. It may not necessarily be applicable to this product.
 NCBI GI #    83304988
 NCBI GeneID    23114
 NCBI Accession #    O94856.4 [Other Products]
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 UniProt Primary Accession #    O94856 [Other Products]
 UniProt Secondary Accession #    Q149P5; Q5T2F0; Q5T2F1; Q5T2F2; Q5T2F3; Q5T2F4; B2RNN8; B3KQZ1; B5MDP6; B5MDR6; B7ZMD8 [Other Products]
 UniProt Related Accession #    O94856 [Other Products]
 Molecular Weight    1240
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 NCBI Official Full Name    Neurofascin
 NCBI Official Synonym Full Names    neurofascin
 NCBI Official Symbol    NFASC [Similar Products]
 NCBI Official Synonym Symbols   
NF; NRCAML
[Similar Products]
 NCBI Protein Information    neurofascin; neurofascin homolog
 UniProt Protein Name    Neurofascin
 Protein Family    Neurofascin
 UniProt Gene Name    NFASC [Similar Products]
 UniProt Synonym Gene Names    KIAA0756 [Similar Products]
 UniProt Entry Name    NFASC_HUMAN
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 NCBI Summary for NFASC    This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
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 UniProt Comments for NFASC    neurofascin: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 13 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: focal adhesion; paranode region of axon; integral to membrane; plasma membrane; intracellular

Molecular Function: protein binding

Biological Process: myelination; heterotypic cell-cell adhesion; axon guidance; clustering of voltage-gated sodium channels; synapse organization and biogenesis; transmission of nerve impulse; peripheral nervous system development; paranodal junction assembly
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 Research Articles on NFASC    1. Autoantibodies to NF155 identify a inflammatory demyelinating polyradiculoneuropathy subtype characterized by severe neuropathy, poor response to intravenous immunoglobulin, and disabling tremor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NFASC antibodyDiseases associated with anti-NFASC antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Neurofascin Interactions Pathway antibodies  Neurofascin Interactions Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with NFASC and Nervous System Diseases
 Disease Models, Animal Antibodies  >13 publications with NFASC and Disease Models, Animal
 Brain Diseases Antibodies  >12 publications with NFASC and Brain Diseases
 Nerve Degeneration Antibodies  >5 publications with NFASC and Nerve Degeneration
 Inflammation Antibodies  >4 publications with NFASC and Inflammation
 Congenital Abnormalities Antibodies  >1 publications with NFASC and Congenital Abnormalities
 Abnormalities, Drug-Induced Antibodies  >1 publications with NFASC and Abnormalities, Drug-Induced
Organs/Tissues associated with anti-NFASC antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >112 publications with NFASC and Nerve
 Brain Antibodies  >49 publications with NFASC and Brain
 Embryonic Tissue Antibodies  >11 publications with NFASC and Embryonic Tissue
 Spinal Cord Antibodies  >11 publications with NFASC and Spinal Cord
 Blood Antibodies  >9 publications with NFASC and Blood
 Eye Antibodies  >6 publications with NFASC and Eye
 Kidney Antibodies  >4 publications with NFASC and Kidney
 Muscle Antibodies  >2 publications with NFASC and Muscle
 Ear Antibodies  >1 publications with NFASC and Ear
 Placenta Antibodies  >1 publications with NFASC and Placenta
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