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anti-NFE2L2 antibody :: Rabbit anti-Human NFE2L2 / NRF2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242657
Unit / Price
0.25 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFE2L2 / NRF2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human NFE2L2 / NRF2

 Product Synonym Names    Anti-NFE2L2 / NRF2 Antibody (aa569-588) IHC-plus; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; NRF2; Human NFE2L2; NRF2
 Product Gene Name   

anti-NFE2L2 antibody

[Similar Products]
 Product Synonym Gene Name    NRF2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600492
 3D Structure    ModBase 3D Structure for Q16236
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunoaffinity Purified
 Form/Format    10mM PBS/1% BSA buffer pH 7.4 with 0.1% sodium azide.
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 Target Species    Human
 Immunogen Description    Synthetic peptide corresponding to aa 569-588 of human Nrf2 protein.
 Immunogen Type    Synthetic peptide
 Immunogen    NFE2L2 / NRF2 antibody was raised against synthetic peptide corresponding to aa 569-588 of human Nrf2 protein.
 Antigen Modification    aa569-588
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 Preparation and Storage    Store at 2 degree C to 8 degree C degrees. Do not freeze.
 Other Notes    Small volumes of anti-NFE2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NFE2L2 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-NFE2L2 antibody    IHC-P (1:200)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-NFE2L2 antibody    Anti-NRF2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-NFE2L2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NFE2L2 antibody    Anti-NRF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-NFE2L2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NFE2L2. It may not necessarily be applicable to this product.
 NCBI GI #    20149576
 NCBI GeneID    4780
 NCBI Accession #    NP_006155.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006164.4 [Other Products]
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 UniProt Primary Accession #    Q16236 [Other Products]
 UniProt Secondary Accession #    Q53RW6; Q59HH2; Q96F71; B2RBU2; B4E338; E9PGJ7 [Other Products]
 UniProt Related Accession #    Q16236 [Other Products]
 Molecular Weight    65,356 Da
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 NCBI Official Full Name    nuclear factor erythroid 2-related factor 2 isoform 1
 NCBI Official Synonym Full Names    nuclear factor, erythroid 2-like 2
 NCBI Official Symbol    NFE2L2 [Similar Products]
 NCBI Official Synonym Symbols   
NRF2
[Similar Products]
 NCBI Protein Information    nuclear factor erythroid 2-related factor 2; HEBP1; NFE2-related factor 2; NF-E2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid derived 2, like 2
 UniProt Protein Name    Nuclear factor erythroid 2-related factor 2
 UniProt Synonym Protein Names   
HEBP1; Nuclear factor, erythroid derived 2, like 2
 Protein Family    Nuclear factor erythroid 2-related factor
 UniProt Gene Name    NFE2L2 [Similar Products]
 UniProt Synonym Gene Names    NRF2; NF-E2-related factor 2; NFE2-related factor 2 [Similar Products]
 UniProt Entry Name    NF2L2_HUMAN
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 NCBI Summary for NFE2L2    This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for NFE2L2    NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; cytosol; nucleus; chromatin

Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of blood coagulation; unfolded protein response; regulation of embryonic development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on NFE2L2    1. Nrf2 SNPs were associated with BP in Japanese HD patients. More notably, rs35652124 was associated with cardiovascular mortality in these patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFE2L2 antibodyPathways associated with anti-NFE2L2 antibody
 Reference Product  PubMed Publications
 HMOX1 antibody  >1011 publications with NFE2L2 and HMOX1
 KEAP1 antibody  >711 publications with NFE2L2 and KEAP1
 NQO1 antibody  >483 publications with NFE2L2 and NQO1
 JUN antibody  >396 publications with NFE2L2 and JUN
 CUL3 antibody  >66 publications with NFE2L2 and CUL3
 MAFG antibody  >23 publications with NFE2L2 and MAFG
 PMF1 antibody  >7 publications with NFE2L2 and PMF1
 CREBBP antibody  >6 publications with NFE2L2 and CREBBP
 UBC antibody  >3 publications with NFE2L2 and UBC
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
Diseases associated with anti-NFE2L2 antibodyOrgans/Tissues associated with anti-NFE2L2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >561 publications with NFE2L2 and Inflammation
 Cardiovascular Diseases Antibodies  >278 publications with NFE2L2 and Cardiovascular Diseases
 Necrosis Antibodies  >256 publications with NFE2L2 and Necrosis
 Liver Diseases Antibodies  >245 publications with NFE2L2 and Liver Diseases
 Kidney Diseases Antibodies  >108 publications with NFE2L2 and Kidney Diseases
 Liver Neoplasms Antibodies  >105 publications with NFE2L2 and Liver Neoplasms
 Fibrosis Antibodies  >104 publications with NFE2L2 and Fibrosis
 Drug-Induced Liver Injury Antibodies  >104 publications with NFE2L2 and Drug-Induced Liver Injury
 Lung Neoplasms Antibodies  >96 publications with NFE2L2 and Lung Neoplasms
 Gastrointestinal Diseases Antibodies  >95 publications with NFE2L2 and Gastrointestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >553 publications with NFE2L2 and Liver
 Blood Antibodies  >446 publications with NFE2L2 and Blood
 Lung Antibodies  >392 publications with NFE2L2 and Lung
 Brain Antibodies  >333 publications with NFE2L2 and Brain
 Vascular Antibodies  >263 publications with NFE2L2 and Vascular
 Muscle Antibodies  >203 publications with NFE2L2 and Muscle
 Kidney Antibodies  >193 publications with NFE2L2 and Kidney
 Heart Antibodies  >185 publications with NFE2L2 and Heart
 Skin Antibodies  >107 publications with NFE2L2 and Skin
 Nerve Antibodies  >80 publications with NFE2L2 and Nerve
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