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anti-NFKB1  antibody :: Rabbit NFKB1  Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2538688
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFKB1 , Polyclonal Antibody

 Also Known As   

NFKB1  Polyclonal Antibody

 Product Synonym Names    p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
 Product Gene Name   

anti-NFKB1  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164011
 3D Structure    ModBase 3D Structure for P19838
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-NFKB1  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NFKB1  antibody

   Background: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-NFKB1  antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NFKB1  antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100
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 Western blot of anti-NFKB1  antibody    Western blot analysis of extracts of various cell lines, using NFKB1 antibody.
anti-NFKB1  antibody Western blot image
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 Immunohistochemistry of anti-NFKB1  antibody    Immunohistochemistry of paraffinembedded mouse lung using NFKB1 antibody at dilution of1:200 (400x lens).
anti-NFKB1  antibody Immunohistochemistry (IHC) image
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 Immunofluorescence of anti-NFKB1  antibody    Immunofluorescence analysis of A549 cell using NFKB1 antibody. Blue: DAPI for nuclear staining.
anti-NFKB1  antibody Immunofluorescence image
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NCBI/Uniprot data below describe general gene information for NFKB1 . It may not necessarily be applicable to this product.
 NCBI GI #    8574070
 NCBI GeneID    4790
 NCBI Accession #    CAB94757.1 [Other Products]
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 UniProt Primary Accession #    P19838 [Other Products]
 UniProt Secondary Accession #    Q68D84; Q86V43; Q8N4X7; Q9NZC0; A8K5Y5; B3KVE8 [Other Products]
 UniProt Related Accession #    P19838 [Other Products]
 Molecular Weight    Calculated MW: 105kDa
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 NCBI Official Full Name    NFKB1
 NCBI Official Synonym Full Names    nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 NCBI Official Symbol    NFKB1 [Similar Products]
 NCBI Official Synonym Symbols   
p50; KBF1; p105; EBP-1; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
[Similar Products]
 NCBI Protein Information    nuclear factor NF-kappa-B p105 subunit
 UniProt Protein Name    Nuclear factor NF-kappa-B p105 subunit
 UniProt Synonym Protein Names   
DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 UniProt Gene Name    NFKB1 [Similar Products]
 UniProt Entry Name    NFKB1_HUMAN
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 NCBI Summary for NFKB1     This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
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 UniProt Comments for NFKB1     NFkB-p105: a transcription factor of the nuclear factor-kappaB ( NFkB) group. Undergoes cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of NFkB. NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: cytoplasm; cytosol; mitochondrion; neuron projection; nucleoplasm; nucleus

Molecular Function: actinin binding; chromatin binding; heat shock protein binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity; transcription factor binding

Biological Process: activation of NF-kappaB transcription factor; apoptosis; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; membrane protein intracellular domain proteolysis; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of apoptosis; negative regulation of cellular protein metabolic process; negative regulation of cholesterol transport; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to copper ion; response to oxidative stress; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter

Disease: Immunodeficiency, Common Variable, 12
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 Research Articles on NFKB1     1. Trim44 promotes non-small cell lung cancer development through activation of NF-kappaB signaling via upregulating CXCL16 and MMP9 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFKB1  antibodyPathways associated with anti-NFKB1  antibody
 Reference Product  PubMed Publications
 RELA antibody  >139 publications with NFKB1  and RELA
 IKBKB antibody  >52 publications with NFKB1  and IKBKB
 NFKBIA antibody  >45 publications with NFKB1  and NFKBIA
 CHUK antibody  >16 publications with NFKB1  and CHUK
 MAP3K8 antibody  >11 publications with NFKB1  and MAP3K8
 BIRC3 antibody  >7 publications with NFKB1  and BIRC3
 HDAC1 antibody  >7 publications with NFKB1  and HDAC1
 BCL3 antibody  >6 publications with NFKB1  and BCL3
 EP300 antibody  >1 publications with NFKB1  and EP300
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
Diseases associated with anti-NFKB1  antibodyOrgans/Tissues associated with anti-NFKB1  antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >224 publications with NFKB1  and Inflammation
 Necrosis Antibodies  >140 publications with NFKB1  and Necrosis
 Cardiovascular Diseases Antibodies  >62 publications with NFKB1  and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >37 publications with NFKB1  and Disease Models, Animal
 Nervous System Diseases Antibodies  >30 publications with NFKB1  and Nervous System Diseases
 Liver Diseases Antibodies  >27 publications with NFKB1  and Liver Diseases
 Adenocarcinoma Antibodies  >21 publications with NFKB1  and Adenocarcinoma
 Heart Diseases Antibodies  >18 publications with NFKB1  and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >15 publications with NFKB1  and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >14 publications with NFKB1  and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >204 publications with NFKB1  and Blood
 Vascular Antibodies  >66 publications with NFKB1  and Vascular
 Bone Antibodies  >64 publications with NFKB1  and Bone
 Liver Antibodies  >55 publications with NFKB1  and Liver
 Lung Antibodies  >45 publications with NFKB1  and Lung
 Bone Marrow Antibodies  >37 publications with NFKB1  and Bone Marrow
 Brain Antibodies  >37 publications with NFKB1  and Brain
 Kidney Antibodies  >31 publications with NFKB1  and Kidney
 Muscle Antibodies  >29 publications with NFKB1  and Muscle
 Heart Antibodies  >23 publications with NFKB1  and Heart
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