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anti-NFKBIA antibody :: Rabbit NFKBIA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126855
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFKBIA, Polyclonal Antibody

★Popular Item★
 Also Known As   

NFKBIA Polyclonal Antibody

 Product Synonym Names    NFKBIA; IKBA; MAD-3; NFKBI
 Product Gene Name   

anti-NFKBIA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612132
 3D Structure    ModBase 3D Structure for P25963
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human NFKBIA
 Calculated Molecular Weight    39kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-NFKBIA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NFKBIA antibody

   The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkappaB proteins (1-3). Activation occurs via phosphorylation of IkappaBalpha at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-kappaB (3-7). IkappaBalpha phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IkappaB at these activating sites have been identified (8).
 Product Categories/Family for anti-NFKBIA antibody    Polyclonal
 Applications Tested/Suitable for anti-NFKBIA antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

 Application Notes for anti-NFKBIA antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:20 - 1:100
IP: 1:20 - 1:100
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 Western Blot (WB) of anti-NFKBIA antibody    Western blot analysis of extracts of various cell lines, using NFKBIA antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 3s.
anti-NFKBIA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NFKBIA. It may not necessarily be applicable to this product.
 NCBI GI #    126682
 NCBI GeneID    4792
 NCBI Accession #    P25963.1 [Other Products]
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 UniProt Primary Accession #    P25963 [Other Products]
 UniProt Secondary Accession #    B2R8L6 [Other Products]
 UniProt Related Accession #    P25963 [Other Products]
 Molecular Weight    317
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 NCBI Official Full Name    NF-kappa-B inhibitor alpha
 NCBI Official Synonym Full Names    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
 NCBI Official Symbol    NFKBIA [Similar Products]
 NCBI Official Synonym Symbols   
IKBA; MAD-3; NFKBI
[Similar Products]
 NCBI Protein Information    NF-kappa-B inhibitor alpha; ikB-alpha; IkappaBalpha; I-kappa-B-alpha; nuclear factor of kappa light chain gene enhancer in B-cells; major histocompatibility complex enhancer-binding protein MAD3
 UniProt Protein Name    NF-kappa-B inhibitor alpha
 UniProt Synonym Protein Names   
I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
 Protein Family    NF-kappa-B inhibitor
 UniProt Gene Name    NFKBIA [Similar Products]
 UniProt Synonym Gene Names    IKBA; MAD3; NFKBI; IkB-alpha; IkappaBalpha [Similar Products]
 UniProt Entry Name    IKBA_HUMAN
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 NCBI Summary for NFKBIA    This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
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 UniProt Comments for NFKBIA    IkB-alpha: a regulatory protein that inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation.

Protein type: Inhibitor; DNA-binding

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: identical protein binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; heat shock protein binding; nuclear localization sequence binding; protein complex binding; transcription factor binding

Biological Process: viral reproduction; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of cellular protein metabolic process; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; cytoplasmic sequestering of NF-kappaB; positive regulation of interferon type I production; lipopolysaccharide-mediated signaling pathway; toll-like receptor 4 signaling pathway; cytoplasmic sequestering of transcription factor; negative regulation of myeloid cell differentiation; MyD88-independent toll-like receptor signaling pathway; regulation of NF-kappaB import into nucleus; negative regulation of DNA binding; toll-like receptor 2 signaling pathway; regulation of cell proliferation; MyD88-dependent toll-like receptor signaling pathway; protein import into nucleus, translocation; inhibition of NF-kappaB transcription factor; response to muramyl dipeptide; toll-like receptor signaling pathway; innate immune response; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of apoptosis

Disease: Ectodermal Dysplasia, Anhidrotic, With T-cell Immunodeficiency, Autosomal Dominant
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 Research Articles on NFKBIA    1. MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFKBIA antibodyPathways associated with anti-NFKBIA antibody
 Reference Product  PubMed Publications
 NFKB1 antibody  >35 publications with NFKBIA and NFKB1
 RELA antibody  >17 publications with NFKBIA and RELA
 IKBKB antibody  >15 publications with NFKBIA and IKBKB
 CHUK antibody  >5 publications with NFKBIA and CHUK
 UBC antibody  >2 publications with NFKBIA and UBC
 SRC antibody  >1 publications with NFKBIA and SRC
 IKBKG antibody  >1 publications with NFKBIA and IKBKG
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with anti-NFKBIA antibodyOrgans/Tissues associated with anti-NFKBIA antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >37 publications with NFKBIA and Inflammation
 Necrosis Antibodies  >22 publications with NFKBIA and Necrosis
 Cardiovascular Diseases Antibodies  >10 publications with NFKBIA and Cardiovascular Diseases
 Psoriasis Antibodies  >9 publications with NFKBIA and Psoriasis
 Nervous System Diseases Antibodies  >9 publications with NFKBIA and Nervous System Diseases
 Liver Diseases Antibodies  >9 publications with NFKBIA and Liver Diseases
 Hodgkin Disease Antibodies  >7 publications with NFKBIA and Hodgkin Disease
 Neoplasms, Experimental Antibodies  >6 publications with NFKBIA and Neoplasms, Experimental
 Heart Diseases Antibodies  >6 publications with NFKBIA and Heart Diseases
 Liver Neoplasms Antibodies  >5 publications with NFKBIA and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with NFKBIA and Blood
 Liver Antibodies  >13 publications with NFKBIA and Liver
 Lung Antibodies  >13 publications with NFKBIA and Lung
 Brain Antibodies  >12 publications with NFKBIA and Brain
 Vascular Antibodies  >9 publications with NFKBIA and Vascular
 Bone Antibodies  >9 publications with NFKBIA and Bone
 Skin Antibodies  >7 publications with NFKBIA and Skin
 Heart Antibodies  >7 publications with NFKBIA and Heart
 Kidney Antibodies  >5 publications with NFKBIA and Kidney
 Muscle Antibodies  >4 publications with NFKBIA and Muscle
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