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anti-NFS1 antibody :: Rabbit anti-Human, Mouse NFS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045600
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFS1, Polyclonal Antibody

★Popular Item★
 Also Known As   

NFS1 Antibody

 Product Synonym Names    Cysteine desulfurase, mitochondrial; NFS1; NIFS; HUSSY-08
 Product Gene Name   

anti-NFS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603485
 3D Structure    ModBase 3D Structure for Q9Y697
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Cysteine desulfurase, mitochondrial protein (C-250AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-85785 / sc-85784 / sc-85786 / sc-98420
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NFS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NFS1 antibody

   Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.
 Applications Tested/Suitable for anti-NFS1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

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 Western Blot (WB) of anti-NFS1 antibody    Western blot
All lanes: NFS1 antibody at 6.21ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:Hela whole cell lysate
Lane 3:mouse kidney tissue
Lane 4:K562 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 51,45 kDa
Observed band size: 50 kDa,85 kDa

anti-NFS1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NFS1 antibody    Immunohistochemistry of paraffin-embedded human colon cancer tissue using MBS7045600 at dilution 1:100
anti-NFS1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunoprecipitation (IP) of anti-NFS1 antibody    Immunoprecipitating NFS1 in HeLa whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug)instead of MBS7045600 in HeLa whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS7045600(4ug)+ HeLa whole cell lysate(500ug)
Lane 3: HeLa whole cell lysate (20ug)

anti-NFS1 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for NFS1. It may not necessarily be applicable to this product.
 NCBI GI #    312222769
 NCBI GeneID    9054
 NCBI Accession #    NP_001185918.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001198989.1 [Other Products]
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 UniProt Primary Accession #    Q9Y697 [Other Products]
 UniProt Secondary Accession #    Q6P0L8; Q9NTZ5; Q9Y481; B3KMA5; B4DXK9; E1P5R8; F5GYK5 [Other Products]
 UniProt Related Accession #    Q9Y697 [Other Products]
 Molecular Weight    44,362 Da
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 NCBI Official Full Name    cysteine desulfurase, mitochondrial isoform b
 NCBI Official Synonym Full Names    NFS1, cysteine desulfurase
 NCBI Official Symbol    NFS1 [Similar Products]
 NCBI Official Synonym Symbols   
IscS; NIFS; HUSSY-08
[Similar Products]
 NCBI Protein Information    cysteine desulfurase, mitochondrial
 UniProt Protein Name    Cysteine desulfurase, mitochondrial
 Protein Family    Cysteine desulfurase
 UniProt Gene Name    NFS1 [Similar Products]
 UniProt Synonym Gene Names    NIFS [Similar Products]
 UniProt Entry Name    NFS1_HUMAN
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 NCBI Summary for NFS1    Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
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 UniProt Comments for NFS1    NFS1: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 2.8.1.7; Transferase; Mitochondrial; Cofactor and Vitamin Metabolism - thiamine

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrion; nucleolus; nucleoplasm; nucleus

Molecular Function: cysteine desulfurase activity; protein binding; protein homodimerization activity

Biological Process: iron incorporation into metallo-sulfur cluster; molybdopterin cofactor biosynthetic process; protein complex assembly; sulfur amino acid metabolic process
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 Research Articles on NFS1    1. Our findings highlight that the ISD11 R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFS1 antibodyPathways associated with anti-NFS1 antibody
 Reference Product  PubMed Publications
 ISCU antibody  >20 publications with NFS1 and ISCU
 FXN antibody  >11 publications with NFS1 and FXN
 HSCB antibody  >3 publications with NFS1 and HSCB
 MOCS3 antibody  >3 publications with NFS1 and MOCS3
 FDX1 antibody  >2 publications with NFS1 and FDX1
 LYRM4 antibody  >2 publications with NFS1 and LYRM4
 ISCA1 antibody  >1 publications with NFS1 and ISCA1
 MPST antibody  >1 publications with NFS1 and MPST
 Products by Pathway  Pathway Diagram
 L-alanine Biosynthesis III Pathway antibodies  L-alanine Biosynthesis III Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Mitochondrial Iron-sulfur Cluster Biogenesis Pathway antibodies  Mitochondrial Iron-sulfur Cluster Biogenesis Pathway Diagram
 Molybdenum Cofactor Biosynthesis Pathway antibodies  Molybdenum Cofactor Biosynthesis Pathway Diagram
 Sulfur Relay System Pathway antibodies  Sulfur Relay System Pathway Diagram
 Sulfur Relay System Pathway antibodies  Sulfur Relay System Pathway Diagram
 Thiamine Metabolism Pathway antibodies  Thiamine Metabolism Pathway Diagram
Diseases associated with anti-NFS1 antibodyOrgans/Tissues associated with anti-NFS1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with NFS1 and Liver Diseases
 Disease Models, Animal Antibodies  >1 publications with NFS1 and Disease Models, Animal
 Hypertrophy Antibodies  >1 publications with NFS1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with NFS1 and Muscle
 Liver Antibodies  >4 publications with NFS1 and Liver
 Blood Antibodies  >3 publications with NFS1 and Blood
 Heart Antibodies  >2 publications with NFS1 and Heart
 Spleen Antibodies  >1 publications with NFS1 and Spleen
 Kidney Antibodies  >1 publications with NFS1 and Kidney
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