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anti-NFYA antibody :: Rabbit anti-Human NFYA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240835
Immunohistochemistry (IHC)
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFYA, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human NFYA

 Product Synonym Names    Anti-NFYA Antibody (N-Terminus) IHC-plus; NFYA; CBF-A; CBF-B; HAP2; HAP2 CCAAT-binding protein; NF-YA; Human NFYA
 Product Gene Name   

anti-NFYA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    189903
 3D Structure    ModBase 3D Structure for P23511
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    NF-Y (A subunit specific) peptide corresponding to a region near the N-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
 Purity/Purification    Sterile filtered
 Form/Format    Serum - liquid, 0.01% sodium azide.
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 Target Species    Human
 Antigen Modification    N-Terminus
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-NFYA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NFYA antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA), Gel shift

 Application Notes for anti-NFYA antibody    ELISA, GS, IF, IHC-P (1:400), IP, WB (1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-NFYA antibody    Anti-NFYA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
anti-NFYA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NFYA. It may not necessarily be applicable to this product.
 NCBI GI #    11496974
 NCBI GeneID    4800
 NCBI Accession #    NP_068351.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021705.3 [Other Products]
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 UniProt Primary Accession #    P23511 [Other Products]
 UniProt Secondary Accession #    Q8IXU0 [Other Products]
 UniProt Related Accession #    P23511 [Other Products]
 Molecular Weight    33,939 Da
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 NCBI Official Full Name    nuclear transcription factor Y subunit alpha isoform 2
 NCBI Official Synonym Full Names    nuclear transcription factor Y, alpha
 NCBI Official Symbol    NFYA [Similar Products]
 NCBI Official Synonym Symbols   
HAP2; CBF-A; CBF-B; NF-YA
[Similar Products]
 NCBI Protein Information    nuclear transcription factor Y subunit alpha; HAP2 CCAAT-binding protein; Transcription factor NF-Y, A subunit; CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; nuclear transcription factor Y subunit A; CCAAT-binding transcription factor subunit B
 UniProt Protein Name    Nuclear transcription factor Y subunit alpha
 UniProt Synonym Protein Names   
CAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YA
 Protein Family    Nuclear transcription factor
 UniProt Gene Name    NFYA [Similar Products]
 UniProt Synonym Gene Names    NF-YA [Similar Products]
 UniProt Entry Name    NFYA_HUMAN
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 NCBI Summary for NFYA    The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NFYA    NFYA: stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. Involved in cisplatin resistance. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleoplasm; CCAAT-binding factor complex; nucleus

Molecular Function: protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; rhythmic process; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process
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 Research Articles on NFYA    1. Association of p21 with NF-YA suppresses the expression of PLK1 and prevents mitotic death in response to DNA damage.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFYA antibodyPathways associated with anti-NFYA antibody
 Reference Product  PubMed Publications
 NFYB antibody  >16 publications with NFYA and NFYB
 SP1 antibody  >13 publications with NFYA and SP1
 NFYC antibody  >9 publications with NFYA and NFYC
 ZHX1 antibody  >3 publications with NFYA and ZHX1
 HSPA5 antibody  >1 publications with NFYA and HSPA5
 CDK2 antibody  >1 publications with NFYA and CDK2
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with anti-NFYA antibodyOrgans/Tissues associated with anti-NFYA antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >5 publications with NFYA and Carcinoma
 Breast Neoplasms Antibodies  >3 publications with NFYA and Breast Neoplasms
 Inflammation Antibodies  >2 publications with NFYA and Inflammation
 Brain Diseases Antibodies  >1 publications with NFYA and Brain Diseases
 Fibrosis Antibodies  >1 publications with NFYA and Fibrosis
 Lymphoma Antibodies  >1 publications with NFYA and Lymphoma
 Stomach Neoplasms Antibodies  >1 publications with NFYA and Stomach Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with NFYA and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with NFYA and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >1 publications with NFYA and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with NFYA and Blood
 Bone Antibodies  >5 publications with NFYA and Bone
 Bone Marrow Antibodies  >3 publications with NFYA and Bone Marrow
 Muscle Antibodies  >3 publications with NFYA and Muscle
 Kidney Antibodies  >2 publications with NFYA and Kidney
 Lung Antibodies  >2 publications with NFYA and Lung
 Heart Antibodies  >2 publications with NFYA and Heart
 Testis Antibodies  >2 publications with NFYA and Testis
 Uterus Antibodies  >1 publications with NFYA and Uterus
 Stomach Antibodies  >1 publications with NFYA and Stomach
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