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anti-NFkappaB-p100 antibody :: Rabbit NFkappaB-p100 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536361
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFkappaB-p100, Polyclonal Antibody

★Popular Item★
 Also Known As   

NFkappaB-p100 Polyclonal Antibody

 Product Synonym Names    NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10
 Product Gene Name   

anti-NFkappaB-p100 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164012
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from human NFkappaB-p100 around the non-phosphorylation site of S865.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NFkappaB-p100 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NFkappaB-p100 antibody    Cancer; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-NFkappaB-p100 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-NFkappaB-p100 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IP: 1:100, IF: 1:50-1:100, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-NFkappaB-p100 antibody    Western Blot analysis of various cells using NF?B-p100 Polyclonal Antibody at dilution of 1:1000.
anti-NFkappaB-p100 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NFkappaB-p100. It may not necessarily be applicable to this product.
 NCBI GI #    570359559
 NCBI GeneID    4791
 NCBI Accession #    NP_001275653.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288724.1 [Other Products]
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 UniProt Secondary Accession #    Q04860; Q9BU75; Q9H471; Q9H472; A8K9D9; D3DR83 [Other Products]
 UniProt Related Accession #    Q00653; AAB23437 [Other Products]
 Molecular Weight    Calculated MW: 97
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 NCBI Official Full Name    nuclear factor NF-kappa-B p100 subunit isoform b
 NCBI Official Synonym Full Names    nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
 NCBI Official Symbol    NFKB2 [Similar Products]
 NCBI Official Synonym Symbols   
p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
[Similar Products]
 NCBI Protein Information    nuclear factor NF-kappa-B p100 subunit
 UniProt Protein Name    Nuclear factor NF-kappa-B p100 subunit
 UniProt Synonym Protein Names   
DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10
 UniProt Gene Name    NFKB2 [Similar Products]
 UniProt Synonym Gene Names    LYT10; Lyt10 [Similar Products]
 UniProt Entry Name    NFKB2_HUMAN
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 NCBI Summary for NFkappaB-p100    This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for NFkappaB-p100    NFkB-p100: a transcription factor of the nuclear factor-kappaB ( NFkB) group. Precursor of the p52 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two spliced isoforms have been identified. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: Bcl3/NF-kappaB2 complex; cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: chromatin binding; protein binding; transcription coactivator activity; transcription factor activity

Biological Process: activation of NF-kappaB transcription factor; aging; extracellular matrix organization and biogenesis; follicular dendritic cell differentiation; germinal center formation; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to cytokine stimulus; response to lipopolysaccharide; rhythmic process; spleen development; stimulatory C-type lectin receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; tumor necrosis factor-mediated signaling pathway

Disease: Immunodeficiency, Common Variable, 10
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 Research Articles on NFkappaB-p100    1. Data show that NF-kappa-B p52 subunit (p52) interacts with ets transcription factors ETS1/2 factors at the C250T telomerase (TERT) promoter to mediate TERT reactivation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFkappaB-p100 antibodyPathways associated with anti-NFkappaB-p100 antibody
 Reference Product  PubMed Publications
 RELA antibody  >112 publications with NFkappaB-p100 and RELA
 RELB antibody  >111 publications with NFkappaB-p100 and RELB
 TNF antibody  >75 publications with NFkappaB-p100 and TNF
 NFKB1 antibody  >64 publications with NFkappaB-p100 and NFKB1
 IKBKB antibody  >64 publications with NFkappaB-p100 and IKBKB
 CHUK antibody  >23 publications with NFkappaB-p100 and CHUK
 BCL3 antibody  >12 publications with NFkappaB-p100 and BCL3
 BTRC antibody  >2 publications with NFkappaB-p100 and BTRC
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Alternative NF-kappaB Pathway antibodies  Alternative NF-kappaB Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Dectin-1 Mediated Noncanonical NF-kB Signaling Pathway antibodies  Dectin-1 Mediated Noncanonical NF-kB Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-NFkappaB-p100 antibodyOrgans/Tissues associated with anti-NFkappaB-p100 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >88 publications with NFkappaB-p100 and Necrosis
 Inflammation Antibodies  >76 publications with NFkappaB-p100 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >21 publications with NFkappaB-p100 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >20 publications with NFkappaB-p100 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >15 publications with NFkappaB-p100 and Cardiovascular Diseases
 Lung Diseases Antibodies  >14 publications with NFkappaB-p100 and Lung Diseases
 Chromosome Aberrations Antibodies  >13 publications with NFkappaB-p100 and Chromosome Aberrations
 Nervous System Diseases Antibodies  >13 publications with NFkappaB-p100 and Nervous System Diseases
 Lung Neoplasms Antibodies  >9 publications with NFkappaB-p100 and Lung Neoplasms
 Kidney Diseases Antibodies  >8 publications with NFkappaB-p100 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >124 publications with NFkappaB-p100 and Blood
 Bone Antibodies  >44 publications with NFkappaB-p100 and Bone
 Bone Marrow Antibodies  >29 publications with NFkappaB-p100 and Bone Marrow
 Lung Antibodies  >22 publications with NFkappaB-p100 and Lung
 Brain Antibodies  >21 publications with NFkappaB-p100 and Brain
 Spleen Antibodies  >18 publications with NFkappaB-p100 and Spleen
 Prostate Antibodies  >16 publications with NFkappaB-p100 and Prostate
 Lymph Antibodies  >15 publications with NFkappaB-p100 and Lymph
 Lymph Node Antibodies  >15 publications with NFkappaB-p100 and Lymph Node
 Kidney Antibodies  >15 publications with NFkappaB-p100 and Kidney
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