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anti-NGFR P75 antibody :: Rabbit anti-Human NGFR P75 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS852713
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NGFR P75, Polyclonal Antibody

 Also Known As   

NGFR P75 Antibody

 Product Gene Name   

anti-NGFR P75 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162010
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized anti-NGFR p75 antibody purified by protein A column containing 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal NGFR p75 (1) antibody was raised against a 14 amino acid peptide from the intermediate residues of human NGFR P75 protein.
 Reactivity Note    Not yet tested in other species.
 Pathway    nerve growth factor receptor
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 Other Notes    Small volumes of anti-NGFR P75 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NGFR P75 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-NGFR P75 antibody   

Western Blot (WB)

 Application Notes for anti-NGFR P75 antibody    Peptide ELISA titer: 1:40,000-1:80,000
Western blot analysis: 1:200-1,000
Optimal dilutions/concentrations should
be determined by the end user.
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 Testing Data of anti-NGFR P75 antibody    anti-NGFR P75 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NGFR P75. It may not necessarily be applicable to this product.
 NCBI GI #    4505393
 NCBI GeneID    4804
 NCBI Accession #    NP_002498.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001087 [Other Products]
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 UniProt Secondary Accession #    B2R961; B4E096 [Other Products]
 UniProt Related Accession #    P08138 [Other Products]
 Molecular Weight    35,767 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 16
 NCBI Official Synonym Full Names    nerve growth factor receptor
 NCBI Official Symbol    NGFR [Similar Products]
 NCBI Official Synonym Symbols   
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 16
 UniProt Synonym Protein Names   
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271
 UniProt Gene Name    NGFR [Similar Products]
 UniProt Synonym Gene Names    TNFRSF16; NGF receptor [Similar Products]
 UniProt Entry Name    TNR16_HUMAN
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 NCBI Summary for NGFR P75    Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NGFR P75    NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: nucleoplasm; cell surface; integral to plasma membrane; plasma membrane; extracellular region; cytosol; endosome

Molecular Function: protein binding; signal transducer activity; transmembrane receptor activity; ubiquitin protein ligase binding; death receptor activity; nerve growth factor binding; receptor activity; Rab GTPase binding

Biological Process: detection of temperature stimulus; axon guidance; membrane protein intracellular domain proteolysis; hair follicle morphogenesis; central nervous system development; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of odontogenesis of dentine-containing teeth; glucose homeostasis; regulation of caspase activity; regulation of axonogenesis; negative regulation of hair follicle development; negative regulation of cell cycle; intracellular protein transport; positive regulation of fibroblast proliferation; nerve development; positive regulation of axonogenesis; negative regulation of axonogenesis; circadian regulation of gene expression; negative regulation of apoptosis
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Product References and Citations for anti-NGFR P75 antibody

   (1) Jin,H., Pan,Y., Zhao,L.,et,al p75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells. Neoplasia.2007;9 (6): 471-478.
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 Research Articles on NGFR P75    1. elucidating the potential implications of p75(NTR) activity as well as the underlying molecular mechanisms of p75(NTR) will shed new light on the biology of both normal and cancer stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NGFR P75 antibodyPathways associated with anti-NGFR P75 antibody
 Reference Product  PubMed Publications
 NGF antibody  >239 publications with NGFR P75 and NGF
 NTRK1 antibody  >108 publications with NGFR P75 and NTRK1
 BDNF antibody  >46 publications with NGFR P75 and BDNF
 NTF4 antibody  >3 publications with NGFR P75 and NTF4
 TRAF6 antibody  >1 publications with NGFR P75 and TRAF6
 RIPK2 antibody  >1 publications with NGFR P75 and RIPK2
 NGFRAP1 antibody  >1 publications with NGFR P75 and NGFRAP1
 SORT1 antibody  >1 publications with NGFR P75 and SORT1
 MAGED1 antibody  >1 publications with NGFR P75 and MAGED1
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 NF-kB Is Activated And Signals Survival Pathway antibodies  NF-kB Is Activated And Signals Survival Pathway Diagram
 NFG And ProNGF Binds To P75NTR Pathway antibodies  NFG And ProNGF Binds To P75NTR Pathway Diagram
Diseases associated with anti-NGFR P75 antibodyOrgans/Tissues associated with anti-NGFR P75 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >124 publications with NGFR P75 and Nervous System Diseases
 Brain Diseases Antibodies  >60 publications with NGFR P75 and Brain Diseases
 Necrosis Antibodies  >42 publications with NGFR P75 and Necrosis
 Neurodegenerative Diseases Antibodies  >36 publications with NGFR P75 and Neurodegenerative Diseases
 Nerve Degeneration Antibodies  >33 publications with NGFR P75 and Nerve Degeneration
 Inflammation Antibodies  >27 publications with NGFR P75 and Inflammation
 Disease Models, Animal Antibodies  >27 publications with NGFR P75 and Disease Models, Animal
 Mental Disorders Antibodies  >25 publications with NGFR P75 and Mental Disorders
 Pain Antibodies  >16 publications with NGFR P75 and Pain
 Kidney Diseases Antibodies  >15 publications with NGFR P75 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >619 publications with NGFR P75 and Nerve
 Brain Antibodies  >198 publications with NGFR P75 and Brain
 Bone Antibodies  >67 publications with NGFR P75 and Bone
 Skin Antibodies  >49 publications with NGFR P75 and Skin
 Embryonic Tissue Antibodies  >45 publications with NGFR P75 and Embryonic Tissue
 Mouth Antibodies  >34 publications with NGFR P75 and Mouth
 Kidney Antibodies  >26 publications with NGFR P75 and Kidney
 Connective Tissue Antibodies  >23 publications with NGFR P75 and Connective Tissue
 Eye Antibodies  >21 publications with NGFR P75 and Eye
 Prostate Antibodies  >16 publications with NGFR P75 and Prostate
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