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anti-NINJ1 antibody :: Rabbit NINJ1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS153659
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NINJ1, Polyclonal Antibody

★Popular Item★
 Also Known As   

NINJ1 Antibody

 Product Synonym Names    NINJ1; NIN1; NINJURIN; Ninjurin-1; Nerve injury-induced protein 1; ninjurin 1
 Product Gene Name   

anti-NINJ1 antibody

[Similar Products]
 Antibody/Peptide Pairs    NINJ1 peptide (MBS154139) is used for blocking the activity of NINJ1 antibody (MBS153659)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602062
 3D Structure    ModBase 3D Structure for Q92982
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    NINJ1 antibody is human, mouse and rat reactive.
 Purity/Purification    NINJ1 antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    NINJ1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human NINJ1.

The immunogen is located within the last 50 amino acids of NINJ1
 Buffer    NINJ1 antibody is supplied in PBS containing 0.02% sodium azide.
 Positive Control    MBS151732 (Human Brain Tissue Lysate)
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 Preparation and Storage    NINJ1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
 Other Notes    Small volumes of anti-NINJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NINJ1 antibody

   Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons (1,2), suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality (3).
 Applications Tested/Suitable for anti-NINJ1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)

 Application Notes for anti-NINJ1 antibody    NINJ1 antibody can be used for detection of NINJ1 by Western blot at 1 - 2 ug/ml. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL. Optimal dilutions for each application to be determined by the researcher.
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 Western Blot (WB) of anti-NINJ1 antibody    Western blot analysis of NINJ1 in human brain tissue lysate with NINJ1 antibody at 1 μg/ml.
anti-NINJ1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence of anti-NINJ1 antibody    Immunofluorescence of NINJ1 in mouse brain tissue with NINJ1 antibody at 20 ug/ml.
anti-NINJ1 antibody Immunofluorescence image
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 Immunohistochemistry of anti-NINJ1 antibody    Immunohistochemistry of NINJ1 in mouse brain tissue with NINJ1 antibody at 5 ug/ml.
anti-NINJ1 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for NINJ1. It may not necessarily be applicable to this product.
 NCBI GI #    148922911
 NCBI GeneID    4814
 NCBI Accession #    NP_004139 [Other Products]
 NCBI GenBank Nucleotide #    NM_004148.3 [Other Products]
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 UniProt Primary Accession #    Q92982 [Other Products]
 UniProt Secondary Accession #    Q6GU89; Q8WUV5; Q9BT07 [Other Products]
 UniProt Related Accession #    Q92982 [Other Products]
 Molecular Weight    Predicted: 17 kDa

Observed: 16 kDa
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 NCBI Official Full Name    ninjurin-1
 NCBI Official Synonym Full Names    ninjurin 1
 NCBI Official Symbol    NINJ1 [Similar Products]
 NCBI Official Synonym Symbols   
NIN1; NINJURIN
[Similar Products]
 NCBI Protein Information    ninjurin-1; nerve injury-induced protein 1; nerve injury-induced protein-1
 UniProt Protein Name    Ninjurin-1
 UniProt Synonym Protein Names   
Nerve injury-induced protein 1
 Protein Family    Ninjurin
 UniProt Gene Name    NINJ1 [Similar Products]
 UniProt Entry Name    NINJ1_HUMAN
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 NCBI Summary for NINJ1    The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]
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 UniProt Comments for NINJ1    NINJ1: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. Belongs to the ninjurin family.

Protein type: Membrane protein, integral; Cell development/differentiation; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: integral to membrane

Biological Process: nervous system development; tissue regeneration; cell adhesion; positive regulation of cell-matrix adhesion
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 Research Articles on NINJ1    1. The NINJ1 gene polymorphism plays an important role in nerve degeneration in leprosy patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NINJ1 antibodyDiseases associated with anti-NINJ1 antibody
 Reference Product  PubMed Publications
 CDKN1A antibody  >2 publications with NINJ1 and CDKN1A
 WNT7B antibody  >1 publications with NINJ1 and WNT7B
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with NINJ1 and Inflammation
 Carcinoma Antibodies  >4 publications with NINJ1 and Carcinoma
 Necrosis Antibodies  >3 publications with NINJ1 and Necrosis
 Liver Diseases Antibodies  >2 publications with NINJ1 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with NINJ1 and Liver Neoplasms
 Adenocarcinoma Antibodies  >2 publications with NINJ1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with NINJ1 and Carcinoma, Hepatocellular
 Urinary Bladder Neoplasms Antibodies  >2 publications with NINJ1 and Urinary Bladder Neoplasms
 Abnormalities, Drug-Induced Antibodies  >1 publications with NINJ1 and Abnormalities, Drug-Induced
 Carcinoma, Squamous Cell Antibodies  >1 publications with NINJ1 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-NINJ1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with NINJ1 and Blood
 Eye Antibodies  >4 publications with NINJ1 and Eye
 Brain Antibodies  >4 publications with NINJ1 and Brain
 Skin Antibodies  >3 publications with NINJ1 and Skin
 Muscle Antibodies  >3 publications with NINJ1 and Muscle
 Liver Antibodies  >3 publications with NINJ1 and Liver
 Embryonic Tissue Antibodies  >2 publications with NINJ1 and Embryonic Tissue
 Bone Antibodies  >2 publications with NINJ1 and Bone
 Lung Antibodies  >2 publications with NINJ1 and Lung
 Thyroid Antibodies  >1 publications with NINJ1 and Thyroid
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