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anti-NIX antibody :: Rabbit anti-Human NIX / BNIP3L Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240473
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NIX / BNIP3L, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human NIX / BNIP3L

 Product Synonym Names    Anti-NIX / BNIP3L Antibody (aa77-92) IHC-plus; BNIP3L; NIP3-like protein X; NIP3L; NIX; BNIP3a; BNIP3H; Human NIX; BNIP3L
 Product Gene Name   

anti-NIX antibody

[Similar Products]
 Product Synonym Gene Name    BNIP3L [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605368
 3D Structure    ModBase 3D Structure for O60238
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    peptide (daqhesgqsssrgssh) corresponding to amino acids 77 to 92 of human origin, which are identical to those of mouse Bnip3L
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human BNIP3L.
 Immunogen Type    Synthetic peptide
 Immunogen    NIX / BNIP3L antibody was raised against synthetic peptide from human BNIP3L.
 Antigen Modification    aa77-92
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-NIX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NIX antibody

   Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like protein X).
 Product Categories/Family for anti-NIX antibody    Family: Apoptosis
 Applications Tested/Suitable for anti-NIX antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-NIX antibody    IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-NIX antibody    Anti-BNIP3L antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-NIX antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-NIX antibody    Immunofluorescence of Bnip3L in Human Kidney cells with Bnip3L antibody at 10 ug/ml.
anti-NIX antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-NIX antibody    Western blot of Bnip3L in K562 whole cell lysate in the absence (A), or presence (B) of blocking peptide with Bnip3L antibody (IN) at 1 ug/ml.
anti-NIX antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NIX. It may not necessarily be applicable to this product.
 NCBI GI #    4757860
 NCBI GeneID    665
 NCBI Accession #    NP_004322.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004331.2 [Other Products]
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 UniProt Primary Accession #    O60238 [Other Products]
 UniProt Secondary Accession #    Q5JW63; Q8NF87; B0AZS9 [Other Products]
 UniProt Related Accession #    O60238 [Other Products]
 Molecular Weight    19,559 Da
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 NCBI Official Full Name    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
 NCBI Official Synonym Full Names    BCL2/adenovirus E1B 19kDa interacting protein 3-like
 NCBI Official Symbol    BNIP3L [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
 UniProt Protein Name    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
 UniProt Synonym Protein Names   
Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3L
 UniProt Gene Name    BNIP3L [Similar Products]
 UniProt Synonym Gene Names    BNIP3A; BNIP3H; NIX; NIP3L [Similar Products]
 UniProt Entry Name    BNI3L_HUMAN
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 NCBI Summary for NIX    This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]
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 UniProt Comments for NIX    BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family.

Protein type: Apoptosis; Membrane protein, integral; Endoplasmic reticulum; Nuclear envelope; Mitochondrial

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; intrinsic to membrane; nuclear envelope

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding

Biological Process: viral reproduction; positive regulation of apoptosis; defense response to virus; negative regulation of apoptosis
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 Research Articles on NIX    1. Nix protein positively regulates NF-kappaB activation in gliomas
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NIX antibodyPathways associated with anti-NIX antibody
 Reference Product  PubMed Publications
 BNIP3 antibody  >95 publications with NIX and BNIP3
 BCL2 antibody  >22 publications with NIX and BCL2
 HIF1A antibody  >20 publications with NIX and HIF1A
 BCL2L1 antibody  >14 publications with NIX and BCL2L1
 TP53 antibody  >4 publications with NIX and TP53
 ERBB2 antibody  >2 publications with NIX and ERBB2
 CREBBP antibody  >1 publications with NIX and CREBBP
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
Diseases associated with anti-NIX antibodyOrgans/Tissues associated with anti-NIX antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with NIX and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with NIX and Heart Diseases
 Necrosis Antibodies  >14 publications with NIX and Necrosis
 Breast Neoplasms Antibodies  >13 publications with NIX and Breast Neoplasms
 Nervous System Diseases Antibodies  >8 publications with NIX and Nervous System Diseases
 Cardiomyopathies Antibodies  >6 publications with NIX and Cardiomyopathies
 Brain Diseases Antibodies  >6 publications with NIX and Brain Diseases
 Liver Diseases Antibodies  >5 publications with NIX and Liver Diseases
 Lung Diseases Antibodies  >5 publications with NIX and Lung Diseases
 Neoplasm Metastasis Antibodies  >5 publications with NIX and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >21 publications with NIX and Heart
 Blood Antibodies  >18 publications with NIX and Blood
 Muscle Antibodies  >16 publications with NIX and Muscle
 Liver Antibodies  >10 publications with NIX and Liver
 Vascular Antibodies  >10 publications with NIX and Vascular
 Brain Antibodies  >9 publications with NIX and Brain
 Lung Antibodies  >8 publications with NIX and Lung
 Kidney Antibodies  >5 publications with NIX and Kidney
 Prostate Antibodies  >5 publications with NIX and Prostate
 Embryonic Tissue Antibodies  >4 publications with NIX and Embryonic Tissue
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