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anti-TACR3 antibody :: Rabbit anti-Human, Mouse NK3R Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150256
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NK3R (TACR3), Polyclonal Antibody

 Also Known As   

NK3R Antibody

 Product Synonym Names    NK3R; NKR; HH11; NK3R; NK-3R; TAC3RL; TAC3R; Neuromedin-K receptor; NK-3 receptor; NKR; tachykinin receptor 3
 Product Gene Name   

anti-TACR3 antibody

[Similar Products]
 Antibody/Peptide Pairs    NK3R peptide (MBS151959) is used for blocking the activity of NK3R antibody (MBS150256)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614840
 3D Structure    ModBase 3D Structure for P29371
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    NK3R Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R.
 Buffer    NK3R Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    NK3R antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TACR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TACR3 antibody

   NK3R Antibody: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B. NK3R antibody does not recognize NK1R or NK2R.
 Applications Tested/Suitable for anti-TACR3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TACR3 antibody    NK3R antibody can be used for detection of NK3R by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-TACR3 antibody    Western blot analysis of NK3R in RAW264.7 cell lysate with NK3R antibody at (A) 0.5 and (B) 2 μg/mL.
anti-TACR3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TACR3 antibody    Immunohistochemistry of NK3R in human brain tissue with NK3R antibody at 5 μg/mL.
anti-TACR3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TACR3 antibody    Immunofluorescence of NK3R in Human Brain cells with NK3R antibody at 20 μg/mL.
anti-TACR3 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TACR3. It may not necessarily be applicable to this product.
 NCBI GI #    128364
 NCBI GeneID    6870
 NCBI Accession #    P29371.1 [Other Products]
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 UniProt Primary Accession #    P29371 [Other Products]
 UniProt Secondary Accession #    Q0P510 [Other Products]
 UniProt Related Accession #    P29371 [Other Products]
 Molecular Weight    52,202 Da
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 NCBI Official Full Name    Neuromedin-K receptor
 NCBI Official Synonym Full Names    tachykinin receptor 3
 NCBI Official Symbol    TACR3 [Similar Products]
 NCBI Official Synonym Symbols   
NKR; HH11; NK3R; NK-3R; TAC3RL
[Similar Products]
 NCBI Protein Information    neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor
 UniProt Protein Name    Neuromedin-K receptor
 UniProt Synonym Protein Names   
NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
 Protein Family    Neuromedin-K receptor
 UniProt Gene Name    TACR3 [Similar Products]
 UniProt Synonym Gene Names    NK3R; TAC3R; NKR; NK-3R [Similar Products]
 UniProt Entry Name    NK3R_HUMAN
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 NCBI Summary for TACR3    This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TACR3    TACR3: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; tachykinin receptor activity

Biological Process: tachykinin signaling pathway; hyperosmotic salinity response; regulation of dopamine metabolic process; response to morphine; positive regulation of heart rate; response to cocaine; positive regulation of blood pressure; response to estradiol stimulus; aging

Disease: Hypogonadotropic Hypogonadism 11 With Or Without Anosmia
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 Research Articles on TACR3    1. data indicate that GPR54 and TACR3 gene mutations are not a frequent cause of ICPP. The identified A/G synonymous SNP (dbSNP ID: rs10407968) located in exon 1 of the gene is not likely to have a pathogenic role in exon splicing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TACR3 antibodyPathways associated with anti-TACR3 antibody
 Reference Product  PubMed Publications
 TAC3 antibody  >39 publications with TACR3 and TAC3
 KISS1R antibody  >20 publications with TACR3 and KISS1R
 KISS1 antibody  >16 publications with TACR3 and KISS1
 PROK2 antibody  >15 publications with TACR3 and PROK2
 GNRH1 antibody  >11 publications with TACR3 and GNRH1
 TAC1 antibody  >6 publications with TACR3 and TAC1
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with anti-TACR3 antibodyOrgans/Tissues associated with anti-TACR3 antibody
 Disease Name  Pubmed Publications
 Hypogonadism Antibodies  >35 publications with TACR3 and Hypogonadism
 Idiopathic Hypogonadotropic Hypogonadism Antibodies  >10 publications with TACR3 and Idiopathic Hypogonadotropic Hypogonadism
 Disorders of Sex Development Antibodies  >9 publications with TACR3 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >2 publications with TACR3 and Genital Diseases, Male
 Hypertension Antibodies  >2 publications with TACR3 and Hypertension
 Cocaine-Related Disorders Antibodies  >2 publications with TACR3 and Cocaine-Related Disorders
 Brain Diseases Antibodies  >1 publications with TACR3 and Brain Diseases
 Memory Disorders Antibodies  >1 publications with TACR3 and Memory Disorders
 Learning Disorders Antibodies  >1 publications with TACR3 and Learning Disorders
 Cognition Disorders Antibodies  >1 publications with TACR3 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with TACR3 and Muscle
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