NP_062007
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Synonym Full Names
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
NCBI Official Synonym Symbols
NCBI Protein Information
solute carrier family 12 member 1
UniProt Protein Name
RCG26347, isoform CRA_c
UniProt Synonym Protein Names
RCG26347, isoform CRA_c; Slc12a1 protein; Solute carrier family 12 member 1
UniProt Synonym Gene Names
UniProt Entry Name
Q5PQV1_RAT
NCBI Summary for Slc12a1
has bumetamide-sensitive Na(+)-(K+)-Cl- symporter activity; may play a role in sodium and chloride transport in the kidney [RGD, Feb 2006]
UniProt Comments for Slc12a1
NKCC2: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Kidney specific. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Cellular Component: cell surface; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: sodium:potassium:chloride symporter activity; cation:chloride symporter activity
Biological Process: diterpenoid metabolic process; sodium ion transport; protein insertion into membrane from inner side; chloride transport; kidney development; excretion; potassium ion transport; chemical homeostasis
Product References and Citations for anti-Slc12a1 antibody
1.Caceres P.S., Ares G.R., and Ortiz P.A. (2009) J Biol Chem. 284(37): 24965-24971. 2.Xue H., et al. (2009) Neurogastroentrol Motil. 21(10): 1068-1089.
Research Articles on Slc12a1
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Pathways associated with anti-Slc12a1 antibody
Diseases associated with anti-Slc12a1 antibody
Organs/Tissues associated with anti-Slc12a1 antibody
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