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anti-NKD2 antibody :: Goat NKD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420288 anti-NKD2 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NKD2, Polyclonal Antibody

 Also Known As   

Goat anti-NKD2 Antibody

 Product Synonym Names    NKD2; naked cuticle homolog 2 (Drosophila); Dvl-binding protein NKD2; naked cuticle homolog 2; naked cuticle-2; NKD2 antibody; naked cuticle homolog 2 (Drosophila) antibody; Dvl-binding protein NKD2 antibody; naked cuticle homolog 2 antibody; naked cuticle-2 antibody
 Product Gene Name   

anti-NKD2 antibody

[Similar Products]
 Antibody/Peptide Pairs    NKD2 peptide (MBS425749) is used for blocking the activity of NKD2 antibody (MBS420288)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HKRYRQKGRE GHS
 OMIM    607852
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HKRYRQKGREGHS, from the internal region of the protein sequence according to NP_149111.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NKD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NKD2 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-NKD2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave bands at approx 80kDa, 38kDa and 26kDa in Mouse Brain lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 51.5kDa according to Mouse NP_082462.2 and of 50.1kDa according to Human NP_149111.1. All the detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
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NCBI/Uniprot data below describe general gene information for NKD2. It may not necessarily be applicable to this product.
 NCBI GI #    14916427
 NCBI GeneID    85409
 NCBI Accession #    NP_149111.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_033120.3 [Other Products]
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 UniProt Secondary Accession #    Q96EK8; Q9BSN0 [Other Products]
 UniProt Related Accession #    Q969F2 [Other Products]
 Molecular Weight    34,314 Da
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 NCBI Official Full Name    protein naked cuticle homolog 2 isoform 1
 NCBI Official Synonym Full Names    naked cuticle homolog 2
 NCBI Official Symbol    NKD2 [Similar Products]
 NCBI Official Synonym Symbols   
Naked2
[Similar Products]
 NCBI Protein Information    protein naked cuticle homolog 2
 UniProt Protein Name    Protein naked cuticle homolog 2
 Protein Family    Protein naked cuticle
 UniProt Gene Name    NKD2 [Similar Products]
 UniProt Synonym Gene Names    Naked-2; hNkd2 [Similar Products]
 UniProt Entry Name    NKD2_HUMAN
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 NCBI Summary for NKD2    This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
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 UniProt Comments for NKD2    NKD2: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Interacts with RNF25 and TGFA (via cytoplasmic domain). Expressed in kidney, lung, pancreas and spleen. Belongs to the NKD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Cell development/differentiation

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: basolateral plasma membrane; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; lateral plasma membrane

Molecular Function: calcium ion binding; growth factor binding; protein binding; ubiquitin protein ligase binding

Biological Process: exocytosis; Golgi vesicle fusion to target membrane; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway
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 Research Articles on NKD2    1. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NKD2 antibodyDiseases associated with anti-NKD2 antibody
 Products by Pathway  Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >5 publications with NKD2 and Carcinoma
 Lung Neoplasms Antibodies  >4 publications with NKD2 and Lung Neoplasms
 Adenocarcinoma Antibodies  >3 publications with NKD2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >2 publications with NKD2 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with NKD2 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >2 publications with NKD2 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >2 publications with NKD2 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with NKD2 and Pancreatic Neoplasms
 Liver Diseases Antibodies  >2 publications with NKD2 and Liver Diseases
 Nervous System Diseases Antibodies  >1 publications with NKD2 and Nervous System Diseases
Organs/Tissues associated with anti-NKD2 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >8 publications with NKD2 and Bone
 Lung Antibodies  >6 publications with NKD2 and Lung
 Brain Antibodies  >5 publications with NKD2 and Brain
 Blood Antibodies  >4 publications with NKD2 and Blood
 Kidney Antibodies  >3 publications with NKD2 and Kidney
 Testis Antibodies  >2 publications with NKD2 and Testis
 Liver Antibodies  >2 publications with NKD2 and Liver
 Uterus Antibodies  >1 publications with NKD2 and Uterus
 Embryonic Tissue Antibodies  >1 publications with NKD2 and Embryonic Tissue
 Eye Antibodies  >1 publications with NKD2 and Eye
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