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anti-NKX2-1 antibody :: Rabbit NKX2-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820795
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NKX2-1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-NKX2-1 Antibody

 Product Synonym Names    NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1
 Product Gene Name   

anti-NKX2-1 antibody

[Similar Products]
 Antibody/Peptide Pairs    NKX2-1 peptide (MBS822728) is used for blocking the activity of NKX2-1 antibody (MBS820795)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 610978
 3D Structure    ModBase 3D Structure for P43699
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Dog, Pig, Sheep, Zebrafish
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 Specificity    Recognizes endogenous levels of NKX2-1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Entrez Gene    7080 (Human); 21869 (Mouse)
 SwissProt    P43699 (Human); P50220 (Mouse); P23441 (Rat)
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NKX2-1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-NKX2-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NKX2-1 antibody

   Rabbit polyclonal antibody to NKX2-1
 Applications Tested/Suitable for anti-NKX2-1 antibody   

Western Blot (WB)

 Application Notes for anti-NKX2-1 antibody    WB (1/500 - 1/1000)
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 Western Blot (WB) of anti-NKX2-1 antibody    Western blot analysis of NKX2-1 expression in MAD109 (A), HeLa (B), SP2/0 (C) whole cell lysates.
anti-NKX2-1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NKX2-1. It may not necessarily be applicable to this product.
 NCBI GI #    118766339
 NCBI GeneID    7080
 NCBI Accession #    NP_001073136.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079668.2 [Other Products]
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 UniProt Primary Accession #    P43699 [Other Products]
 UniProt Secondary Accession #    O14954; O14955; Q7KZF6; Q9BRJ8; D3DSA3 [Other Products]
 UniProt Related Accession #    P43699 [Other Products]
 Molecular Weight    41,737 Da
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 NCBI Official Full Name    homeobox protein Nkx-2.1 isoform 1
 NCBI Official Synonym Full Names    NK2 homeobox 1
 NCBI Official Symbol    NKX2-1 [Similar Products]
 NCBI Official Synonym Symbols   
BCH; BHC; NK-2; TEBP; TTF1; NKX2A; T/EBP; TITF1; TTF-1; NKX2.1
[Similar Products]
 NCBI Protein Information    homeobox protein Nkx-2.1; NK-2 homolog A; thyroid nuclear factor 1; thyroid transcription factor 1; homeobox protein NK-2 homolog A; thyroid-specific enhancer-binding protein
 UniProt Protein Name    Homeobox protein Nkx-2.1
 UniProt Synonym Protein Names   
Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP
 Protein Family    Homeobox protein
 UniProt Gene Name    NKX2-1 [Similar Products]
 UniProt Synonym Gene Names    NKX2A; TITF1; TTF1; TTF-1; T/EBP [Similar Products]
 UniProt Entry Name    NKX21_HUMAN
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 NCBI Summary for NKX2-1    This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]
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 UniProt Comments for NKX2-1    NKX2-1: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC); also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). This syndrome include neurological, thyroid, and respiratory problems. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; axon guidance; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; rhythmic process; globus pallidus development; forebrain dorsal/ventral pattern formation; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of circadian rhythm; Leydig cell differentiation; phospholipid metabolic process; forebrain development; thyroid gland development; oligodendrocyte differentiation; anatomical structure formation; forebrain neuron fate commitment; negative regulation of cell migration; hippocampus development; induction; cerebral cortex GABAergic interneuron differentiation; cerebral cortex cell migration; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; endoderm development; lung development

Disease: Thyroid Carcinoma, Papillary; Chorea, Benign Hereditary; Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
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 Research Articles on NKX2-1    1. Although rare, the triad of congenital hypothyroidism, neurological, and respiratory signs is highly suggestive of NKX2-1 anomalies
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NKX2-1 antibodyPathways associated with anti-NKX2-1 antibody
 Reference Product  PubMed Publications
 SHH antibody  >48 publications with NKX2-1 and SHH
 PAX8 antibody  >38 publications with NKX2-1 and PAX8
 FOXA2 antibody  >12 publications with NKX2-1 and FOXA2
 SFTPC antibody  >10 publications with NKX2-1 and SFTPC
 TSHR antibody  >8 publications with NKX2-1 and TSHR
 SFTPB antibody  >7 publications with NKX2-1 and SFTPB
 FOXA1 antibody  >7 publications with NKX2-1 and FOXA1
 GATA6 antibody  >6 publications with NKX2-1 and GATA6
 Products by Pathway  Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Diseases associated with anti-NKX2-1 antibodyOrgans/Tissues associated with anti-NKX2-1 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >72 publications with NKX2-1 and Lung Diseases
 Chorea Antibodies  >24 publications with NKX2-1 and Chorea
 Brain Diseases Antibodies  >15 publications with NKX2-1 and Brain Diseases
 Disease Models, Animal Antibodies  >14 publications with NKX2-1 and Disease Models, Animal
 Inflammation Antibodies  >10 publications with NKX2-1 and Inflammation
 Hyperplasia Antibodies  >6 publications with NKX2-1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >5 publications with NKX2-1 and Neoplasms, Experimental
 Craniofacial Abnormalities Antibodies  >4 publications with NKX2-1 and Craniofacial Abnormalities
 Abnormalities, Drug-Induced Antibodies  >3 publications with NKX2-1 and Abnormalities, Drug-Induced
 Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress Antibodies  >3 publications with NKX2-1 and Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >256 publications with NKX2-1 and Thyroid
 Brain Antibodies  >171 publications with NKX2-1 and Brain
 Lung Antibodies  >170 publications with NKX2-1 and Lung
 Embryonic Tissue Antibodies  >66 publications with NKX2-1 and Embryonic Tissue
 Blood Antibodies  >25 publications with NKX2-1 and Blood
 Pituitary Gland Antibodies  >14 publications with NKX2-1 and Pituitary Gland
 Stomach Antibodies  >8 publications with NKX2-1 and Stomach
 Prostate Antibodies  >2 publications with NKX2-1 and Prostate
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