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anti-NKX2-5 antibody :: Rabbit anti-Human NKX2-5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2522630
Unit / Price
0.06 mL  /  $200 +1 FREE 8GB USB
0.12 mL  /  $275 +1 FREE 8GB USB
0.2 mL  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NKX2-5, Polyclonal Antibody

★Popular Item★
 Also Known As   

NKX2-5 Antibody

 Product Synonym Names    CSX; CSX1; VSD3; CHNG5; HLHS2; NKX2E; NKX2.5; NKX4-1
 Product Gene Name   

anti-NKX2-5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2522630 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for P52952
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purification.
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 Immunogen    Recombinant protein of human NKX2-5
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
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 Preparation and Storage    Store at -20C. Avoid freeze/thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NKX2-5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NKX2-5 antibody

   Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development. NKX2-5 encoded by homeobox-containing genes that implicated in commitment to and/or differentiation of the myocardial lineage, and acts as a transcriptional activator of ANF in cooperation with GATA4. During embryonic development, NKX2-5 plays pivotal roles in specifying cardiac progenitors, cardiac morphogenesis, cardiomyocyte differentiation and conduction system development.
 Applications Tested/Suitable for anti-NKX2-5 antibody   

ELISA, WB, IHC

 Application Notes for anti-NKX2-5 antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western blot of anti-NKX2-5 antibody    human heart tissue were subjected to SDS PAGE followed by western blot with NKX2-5 Polyclonal Antibody at dilution of 1:1200.
anti-NKX2-5 antibody Western blot image
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 Immunohistochemical of anti-NKX2-5 antibody    Immunohistochemical of paraffin-embedded human brain using NKX2-5 Polyclonal Antibody at dilution of 1:100 (under 40x lens).
anti-NKX2-5 antibody Immunohistochemical image
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NCBI/Uniprot data below describe general gene information for NKX2-5. It may not necessarily be applicable to this product.
 NCBI GI #    157278563
 NCBI GeneID    1482
 NCBI Accession #    NP_001098382.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001104912.1 [Other Products]
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 UniProt Primary Accession #    P52952 [Other Products]
 Molecular Weight    34kDa
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 NCBI Official Full Name    Nkx2.5 protein
 NCBI Official Symbol    nkx2.5 [Similar Products]
 NCBI Official Synonym Symbols   
Nkx2-5
[Similar Products]
 NCBI Protein Information    Nkx2.5 protein
 Protein Family    Homeobox protein
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 UniProt Comments for NKX2-5    NKX2-5: Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Expressed only in the heart. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: nucleus; transcription factor complex

Molecular Function: chromatin binding; DNA binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: adult heart development; atrial cardiac muscle cell development; cardiac muscle cell differentiation; cardiac muscle morphogensis; cell differentiation; embryonic heart tube development; heart looping; heart morphogenesis; hemopoiesis; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; pharyngeal system development; positive regulation of cardioblast differentiation; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; spleen development; thyroid gland development; vasculogenesis; ventricular cardiac muscle cell development

Disease: Atrial Septal Defect 7 With Or Without Atrioventricular Conduction Defects; Conotruncal Heart Malformations; Hypoplastic Left Heart Syndrome 2; Hypothyroidism, Congenital, Nongoitrous, 5; Tetralogy Of Fallot; Ventricular Septal Defect 3
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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