AAI00426.1
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UniProt Related Accession #
Molecular Weight
31,597 Da
NCBI Official Full Name
Nkx2-6 protein, partial
NCBI Official Synonym Full Names
NK2 homeobox 6
NCBI Official Synonym Symbols
Tix; Nkx2.6; tinman; Nkx-2.6; AV044928 [Similar Products]
NCBI Protein Information
homeobox protein Nkx-2.6
UniProt Protein Name
Homeobox protein Nkx-2.6
UniProt Synonym Protein Names
Homeobox protein NK-2 homolog F
UniProt Synonym Gene Names
UniProt Entry Name
NKX26_MOUSE
UniProt Comments for NKX2-6
NKX2-6: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Defects in NKX2-6 may be a cause of conotruncal heart malformations (CTHM). CTHM defines a group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Belongs to the NK-2 homeobox family.
Protein type: DNA-binding
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: pharyngeal system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; heart development; multicellular organismal development; positive regulation of cell proliferation; embryonic heart tube development; cell differentiation; negative regulation of apoptosis
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Products associated with anti-NKX2-6 antibody
Diseases associated with anti-NKX2-6 antibody
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