NP_001264055.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 31kDa; 101kDa; 107kDa; 113kDa; 114kDa; 120kDa Observed: 110kDa
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 12 isoform 3
NCBI Official Synonym Full Names
NLR family pyrin domain containing 12
NCBI Official Synonym Symbols
RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3 [Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 12
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 12
UniProt Synonym Protein Names
Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide
UniProt Synonym Gene Names
NCBI Summary for NLRP12
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for NLRP12
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
Research Articles on NLRP12
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Disclaimer
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Products associated with anti-NLRP12 antibody
Pathways associated with anti-NLRP12 antibody
Diseases associated with anti-NLRP12 antibody
Organs/Tissues associated with anti-NLRP12 antibody
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