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anti-NLRP3 antibody :: Rabbit anti-Human, Rat NLRP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2526381
Western Blot (WB)
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NLRP3, Polyclonal Antibody

★Popular Item★
 Also Known As   

NLRP3 Antibody

 Product Synonym Names    FCU; MWS; FCAS; Cias1; Mmig1; NALP3; Pypaf1; AII/AVP; AGTAVPRL
 Product Gene Name   

anti-NLRP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120100
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NLRP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NLRP3 antibody

   Background/Introduction: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
 Applications Tested/Suitable for anti-NLRP3 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NLRP3 antibody    WB (1:500-1:2000); IHC (1:50-1:200); IF (1:50-1:200)
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 Western Blot (WB) of anti-NLRP3 antibody    Western blot analysis of extracts of K-562 cell line, using NLRP3 antibody.
anti-NLRP3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NLRP3. It may not necessarily be applicable to this product.
 NCBI GI #    341865590
 NCBI GeneID    114548
 NCBI Accession #    NP_001230062.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243133.1 [Other Products]
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 UniProt Secondary Accession #    O75434; Q17RS2; Q59H68; Q5JQS8; Q5JQS9; Q6TG35; Q8TCW0; B2RC97; B7ZKS9; B7ZKT2; B7ZKT3 [Other Products]
 UniProt Related Accession #    Q96P20 [Other Products]
 Molecular Weight    118kDa
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 NCBI Official Full Name    NACHT, LRR and PYD domains-containing protein 3 isoform e
 NCBI Official Synonym Full Names    NLR family, pyrin domain containing 3
 NCBI Official Symbol    NLRP3 [Similar Products]
 NCBI Official Synonym Symbols   
AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
[Similar Products]
 NCBI Protein Information    NACHT, LRR and PYD domains-containing protein 3; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; PYRIN-containing APAF1-like protein 1; caterpiller protein 1.1; cold autoinflammatory syndrome 1 protein; cryopyrin; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
 UniProt Protein Name    NACHT, LRR and PYD domains-containing protein 3
 UniProt Synonym Protein Names   
Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1
 Protein Family    NACHT, LRR and PYD domains-containing protein
 UniProt Gene Name    NLRP3 [Similar Products]
 UniProt Synonym Gene Names    C1orf7; CIAS1; NALP3; PYPAF1; CLR1.1 [Similar Products]
 UniProt Entry Name    NALP3_HUMAN
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 NCBI Summary for NLRP3    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
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 UniProt Comments for NLRP3    NLRP3: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1); also known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS); also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs. Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA); also known as neonatal onset multisystem inflammatory disease (NOMID). CINCA is a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis and joint manifestations with recurrent fever and inflammation. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; peptidoglycan binding; ATP binding

Biological Process: caspase activation; apoptosis; negative regulation of acute inflammatory response; interleukin-1 beta production; positive regulation of caspase activity; defense response; positive regulation of interleukin-1 beta secretion; negative regulation of NF-kappaB import into nucleus; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of interleukin-1 beta secretion; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; interleukin-18 production; innate immune response; interleukin-1 secretion; detection of biotic stimulus; inflammatory response; defense response to virus

Disease: Cinca Syndrome; Familial Cold Autoinflammatory Syndrome 1; Muckle-wells Syndrome
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 Research Articles on NLRP3    1. NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1beta
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NLRP3 antibodyDiseases associated with anti-NLRP3 antibody
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >906 publications with NLRP3 and Inflammation
 Death Antibodies  >235 publications with NLRP3 and Death
 MUCKLE-WELLS SYNDROME Antibodies  >183 publications with NLRP3 and MUCKLE-WELLS SYNDROME
 Necrosis Antibodies  >179 publications with NLRP3 and Necrosis
 Cryopyrin-Associated Periodic Syndromes Antibodies  >137 publications with NLRP3 and Cryopyrin-Associated Periodic Syndromes
 Autoimmune Diseases Antibodies  >136 publications with NLRP3 and Autoimmune Diseases
 FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1 Antibodies  >135 publications with NLRP3 and FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1
 Disease Models, Animal Antibodies  >111 publications with NLRP3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >96 publications with NLRP3 and Cardiovascular Diseases
 Lung Diseases Antibodies  >79 publications with NLRP3 and Lung Diseases
Organs/Tissues associated with anti-NLRP3 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >395 publications with NLRP3 and Blood
 Lung Antibodies  >123 publications with NLRP3 and Lung
 Bone Marrow Antibodies  >103 publications with NLRP3 and Bone Marrow
 Brain Antibodies  >77 publications with NLRP3 and Brain
 Intestine Antibodies  >33 publications with NLRP3 and Intestine
 Connective Tissue Antibodies  >28 publications with NLRP3 and Connective Tissue
 Pancreas Antibodies  >17 publications with NLRP3 and Pancreas
 Thymus Antibodies  >3 publications with NLRP3 and Thymus
 Prostate Antibodies  >2 publications with NLRP3 and Prostate
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