NP_612202
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,681 Da
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 6 isoform 2
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 6
NCBI Official Synonym Symbols
AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR [Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 6; NACHT, LRR and PYD containing protein 6; NACHT, leucine rich repeat and PYD containing 6; PYRIN-containing APAF1-like protein 5; angiotensin II/vasopressin receptor; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 6
UniProt Synonym Protein Names
Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5
UniProt Synonym Gene Names
UniProt Entry Name
NALP6_HUMAN
NCBI Summary for NLRP6
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
UniProt Comments for NLRP6
NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: nuclear membrane; cytoplasm; plasma membrane
Molecular Function: ATP binding; vasopressin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; response to bacterium; wound healing; negative regulation of MAPKKK cascade; regulation of inflammatory response; negative regulation of immune response; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; negative regulation of I-kappaB kinase/NF-kappaB cascade
Research Articles on NLRP6
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Products associated with anti-NLRP6 antibody
Diseases associated with anti-NLRP6 antibody
Organs/Tissues associated with anti-NLRP6 antibody
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