Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow NLRP6 rightarrow Polyclonal NLRP6  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • annexin A4 (ANXA4) ELISA Kit
 • C-reactive protein, CRP ELISA Kit
 • IL-15 ELISA Kit
 • interferon gamma receptor 1 (IFNGR1) ELISA Kit
 • PPME1 Recombinant Protein
 • GNRH1 Antibody
 • 60S Ribosomal Protein L10 (RPL10) Antibody
 • O-6-Methylguanine DNA Methyltransferase (MGMT) ELISA Kit
 • P-Selectin Glycoprotein Ligand 1 (PSGL-1) ELISA Kit
 • FKBP1B Recombinant Protein
 • CD27 Antibody
 • antithrombin-III (SERPINC1) ELISA Kit
 • Cytotoxin-associated protein (CagA) ELISA Kit
 • Alpha-1-Antichymotrypsin (alpha1ACT) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-NLRP6 antibody :: Rabbit anti-Human NLRP6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2519919
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NLRP6, Polyclonal Antibody

★Popular Item★
 Also Known As   

NLRP6 Polyclonal Antibody

 Product Synonym Names    AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
 Product Gene Name   

anti-NLRP6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    609650
 3D Structure    ModBase 3D Structure for P59044
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Affinity purification
 Concentration    0.6mg/mL (lot specific)
Section Bar
 Immunogen    Synthetic peptide of human NLRP6
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Section Bar
 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NLRP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-NLRP6 antibody

   The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-NLRP6 antibody    Cell biology
 Applications Tested/Suitable for anti-NLRP6 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-NLRP6 antibody    IHC: 1:50-1:200
Section Bar
 Immunohistochemistry (IHC) of anti-NLRP6 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using NLRP6 Polyclonal Antibody at dilution 1:40
anti-NLRP6 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-NLRP6 antibody    Immunohistochemistry of paraffin-embedded Human brain tissue using NLRP6 Polyclonal Antibody at dilution 1:40
anti-NLRP6 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for NLRP6. It may not necessarily be applicable to this product.
 NCBI GI #    452085173
 NCBI GeneID    171389
 NCBI Accession #    NP_612202 [Other Products]
 NCBI GenBank Nucleotide #    NM_001276700.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P59044 [Other Products]
 UniProt Secondary Accession #    A8K9F3; E9PJZ8 [Other Products]
 UniProt Related Accession #    P59044 [Other Products]
 Molecular Weight    98,681 Da
Table BarTOPTable Bar
 NCBI Official Full Name    NACHT, LRR and PYD domains-containing protein 6 isoform 2
 NCBI Official Synonym Full Names    NLR family, pyrin domain containing 6
 NCBI Official Symbol    NLRP6 [Similar Products]
 NCBI Official Synonym Symbols   
AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
[Similar Products]
 NCBI Protein Information    NACHT, LRR and PYD domains-containing protein 6; NACHT, LRR and PYD containing protein 6; NACHT, leucine rich repeat and PYD containing 6; PYRIN-containing APAF1-like protein 5; angiotensin II/vasopressin receptor; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
 UniProt Protein Name    NACHT, LRR and PYD domains-containing protein 6
 UniProt Synonym Protein Names   
Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5
 Protein Family    NACHT, LRR and PYD domains-containing protein
 UniProt Gene Name    NLRP6 [Similar Products]
 UniProt Synonym Gene Names    NALP6; PYPAF5 [Similar Products]
 UniProt Entry Name    NALP6_HUMAN
Section Bar
 NCBI Summary for NLRP6    The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Section Bar
 UniProt Comments for NLRP6    NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nuclear membrane; cytoplasm; plasma membrane

Molecular Function: ATP binding; vasopressin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to bacterium; wound healing; negative regulation of MAPKKK cascade; regulation of inflammatory response; negative regulation of immune response; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; negative regulation of I-kappaB kinase/NF-kappaB cascade
Table BarTOPTable Bar
 Research Articles on NLRP6    1. Our results revealed an association between NLRP6/AVR and ADM loci with male essential hypertension, suggesting the existence of sex-specific NLRP6/AVR and ADM variants affecting male susceptibility to essential hypertension.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-NLRP6 antibodyDiseases associated with anti-NLRP6 antibody
 Reference Product  PubMed Publications
 CASP1 antibody  >19 publications with NLRP6 and CASP1
 AIM2 antibody  >10 publications with NLRP6 and AIM2
 PYCARD antibody  >3 publications with NLRP6 and PYCARD
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >23 publications with NLRP6 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with NLRP6 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with NLRP6 and Cardiovascular Diseases
 Hypertension Antibodies  >2 publications with NLRP6 and Hypertension
 Liver Diseases Antibodies  >2 publications with NLRP6 and Liver Diseases
 Brain Diseases Antibodies  >2 publications with NLRP6 and Brain Diseases
 Necrosis Antibodies  >2 publications with NLRP6 and Necrosis
 Fatty Liver, Alcoholic Antibodies  >1 publications with NLRP6 and Fatty Liver, Alcoholic
 Heart Failure Antibodies  >1 publications with NLRP6 and Heart Failure
 Liver Cirrhosis Antibodies  >1 publications with NLRP6 and Liver Cirrhosis
Organs/Tissues associated with anti-NLRP6 antibody
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >13 publications with NLRP6 and Intestine
 Blood Antibodies  >7 publications with NLRP6 and Blood
 Testis Antibodies  >1 publications with NLRP6 and Testis
 Kidney Antibodies  >1 publications with NLRP6 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions