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anti-GRIN2B antibody :: Rabbit NMDA NR2B Subunit Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502087
Testing Data
Unit / Price
0.05 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NMDA NR2B Subunit (GRIN2B), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-NMDA Receptor, NR2B Subunit

 Product Gene Name   

anti-GRIN2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_005103.3 (233806406..234260360, complement). Location: 4q43
 3D Structure    ModBase 3D Structure for Q00960
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat, mouse, human
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 Specificity    Specific for the ~180k NR2B subunit of the NMDA receptor. No reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.
 Purity/Purification    Neat Serum (Unpurified neat serum)
 Form/Format    50 ul neat serum. Adequate amount of material to conduct 10-mini Western Blots.
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 Antigen    Fusion protein from the C-terminus region of the NR2B subunit of rat NMDA receptor.
 Immunogen Information    Fusion protein from the C-terminal region of the NR2B subunit
 Immunogen Species    Rat
 Species Reactivity Note    The antibody has been directly tested for reactivity in Western blots with human, mouse and rat tissue.
 Biological Significance    The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
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 Preparation and Storage    Store at -20 degree C; stable for at least 1 year
 Other Notes    Small volumes of anti-GRIN2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GRIN2B antibody

   Rabbit polyclonal antibody
 Applications Tested/Suitable for anti-GRIN2B antibody   

Western Blot (WB)

 Application Notes for anti-GRIN2B antibody    Quality Control: Western blots performed on each lot.
WB: 1:1000
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 Testing Data of anti-GRIN2B antibody    anti-GRIN2B antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GRIN2B. It may not necessarily be applicable to this product.
 NCBI GI #    6980984
 NCBI GeneID    24410
 NCBI Accession #    NP_036706.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012574.1 [Other Products]
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 UniProt Primary Accession #    Q00960 [Other Products]
 UniProt Secondary Accession #    Q62684 [Other Products]
 UniProt Related Accession #    Q00960 [Other Products]
 Molecular Weight    180
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 NCBI Official Full Name    glutamate receptor ionotropic, NMDA 2B
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, N-methyl D-aspartate 2B
 NCBI Official Symbol    Grin2b [Similar Products]
 NCBI Official Synonym Symbols   
GluN2B
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 2B; NR2B; NMDAR2B; glutamate receptor, ionotropic, NMDA2B; N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 2B
 UniProt Synonym Protein Names   
Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    Grin2b [Similar Products]
 UniProt Synonym Gene Names    GluN2B; NMDAR2B; NR2B [Similar Products]
 UniProt Entry Name    NMDE2_RAT
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 NCBI Summary for GRIN2B    subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006]
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 UniProt Comments for GRIN2B    Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death

By similarity.

Subunit structure: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1, GRIN3A and PPP2CB. Found in a complex with GRIN1 and GRIN3B. Interacts with MAGI3. Interacts with HIP1 and Neto1

By similarity. Interacts with PDZ domains of INADL and DLG4. Interacts with DAPK1

By similarity. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.

Post-translational modification: Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity

By similarity.

Sequence similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. [View classification]
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Product References and Citations for anti-GRIN2B antibody

   • Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD (2003) Tyrosine dephosphorylation and ethanol inhibition of N-methyl-D-aspartate receptor function. J Biol Chem 278:11020-11025.
• Carroll RC, Zukin RS (2002) NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25:571-577.
• Grosshans DR, Clayton DA, Coultrap SJ, Browning MD (2002) LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5:27-33.
• Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724.
• Lu W-Y, Xiong Z-G, Lei S, Orser BA, Browning MD, MacDonald JF (1999) G-protein coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nature Neurosci 2:331-338.
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 Research Articles on GRIN2B    1. Artificial food colors and additives led to an increase in NR2B and nAChR beta2 receptor subunits in male rats and led to decrease in NR2B subunits in female rats.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRIN2B antibodyPathways associated with anti-GRIN2B antibody
 Reference Product  PubMed Publications
 Grin2a antibody  >30 publications with GRIN2B and Grin2a
 Grin1 antibody  >21 publications with GRIN2B and Grin1
 Grik2 antibody  >5 publications with GRIN2B and Grik2
 Grin3b antibody  >3 publications with GRIN2B and Grin3b
 Grin3a antibody  >2 publications with GRIN2B and Grin3a
 Grik1 antibody  >2 publications with GRIN2B and Grik1
 Dlg4 antibody  >1 publications with GRIN2B and Dlg4
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
Diseases associated with anti-GRIN2B antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >39 publications with GRIN2B and Schizophrenia
 Nervous System Diseases Antibodies  >28 publications with GRIN2B and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with GRIN2B and Brain Diseases
 Anxiety Disorders Antibodies  >10 publications with GRIN2B and Anxiety Disorders
 Movement Disorders Antibodies  >10 publications with GRIN2B and Movement Disorders
 Child Development Disorders, Pervasive Antibodies  >9 publications with GRIN2B and Child Development Disorders, Pervasive
 Neoplasms Antibodies  >8 publications with GRIN2B and Neoplasms
 Cognition Disorders Antibodies  >8 publications with GRIN2B and Cognition Disorders
 Epilepsy Antibodies  >8 publications with GRIN2B and Epilepsy
 Intellectual Disability Antibodies  >7 publications with GRIN2B and Intellectual Disability
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