NP_036706.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
166,071 Da
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 2B
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
NCBI Official Synonym Symbols
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2B; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2B
UniProt Synonym Protein Names
Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B
UniProt Synonym Gene Names
UniProt Entry Name
NMDE2_RAT
NCBI Summary for NMDA
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006]
UniProt Comments for NMDA
NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; membrane; postsynaptic density; dendritic spine; terminal button; synapse; cell junction; Z disc; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: neurotransmitter binding; interleukin-1 receptor binding; zinc ion binding; calcium channel activity; beta-catenin binding; drug binding; ionotropic glutamate receptor binding; protein binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; ionotropic glutamate receptor activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; cation channel activity; cell adhesion molecule binding; D2 dopamine receptor binding; receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; fear response; startle response; behavioral fear response; response to toxin; positive regulation of glutamate secretion; rhythmic process; regulation of synaptic plasticity; response to other organism; receptor clustering; response to organic cyclic substance; response to carbohydrate stimulus; positive regulation of synaptic transmission; synaptic transmission; response to magnesium ion; behavioral response to pain; learning and/or memory; calcium ion transport; response to methylmercury; response to electrical stimulus; cation transport; associative learning; cellular response to magnesium starvation; synaptic transmission, glutamatergic; regulation of action potential; in utero embryonic development; hippocampus development; response to amphetamine; learning; response to cocaine; memory; response to manganese ion; detection of mechanical stimulus involved in sensory perception of pain; regulation of postsynaptic membrane potential; sensory organ development; response to ethanol; long-term memory; suckling behavior; response to mechanical stimulus; ionotropic glutamate receptor signaling pathway; response to cytokine stimulus; regulation of MAPKKK cascade; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential; multicellular organismal response to stress; response to amine stimulus
Research Articles on NMDA
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Products associated with anti-NMDA antibody
Pathways associated with anti-NMDA antibody
Diseases associated with anti-NMDA antibody
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