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anti-GRIN1 antibody :: Rabbit NMDAR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175244
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NMDAR1 (GRIN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-NMDAR1 antibody

 Product Synonym Names    Glutamate[NMDA] receptor subunit zeta-1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; GluN1 antibody; Glutamate[NMDA] receptor subunit zeta 1 antibody; Glutamate[NMDA] receptor subunit zeta-1 antibody; Glutamate receptor ionotropic N methyl D aspartate 1 antibody; Grin 1 antibody; Grin1 antibody; MRD8 antibody; N methyl D aspartate receptor antibody; N methyl D aspartate receptor channel antibody; N methyl D aspartate receptor channel subunit zeta 1 antibody; N methyl D aspartate receptor subunit NR1 antibody; N-methyl-D-aspartate receptor antibody; N-methyl-D-aspartate receptor subunit NR1 antibody; NMD-R1 antibody; NMDA 1 antibody; NMDA NR1 antibody; NMDA R1 antibody; NMDA receptor 1 antibody; NMDA1 antibody; NMDAR 1 antibody; NMDAR antibody; Nmdar1 antibody; NMDZ1_HUMAN antibody; NR 1 antibody; NR1 antibody
 Product Gene Name   

anti-GRIN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614254
 3D Structure    ModBase 3D Structure for Q05586
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Reacts with: Human, rat
Predicted to work with: Mouse
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human GRIN1 (36-53aa RKHEQMFREAVNQANKRH), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GRIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GRIN1 antibody

   Description: Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, NMDA 1(GRIN1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: The NMDA receptor(NMDAR) is a specific type of ionotropic glutamate receptor. NMDA(N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia.The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.
 Applications Tested/Suitable for anti-GRIN1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-GRIN1 antibody    Western Blot:
Concentration: 0.1-0.5 ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: n/a

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1 ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: By Heat

Test Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formal/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
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 Testing Data of anti-GRIN1 antibody    anti-GRIN1 antibody Testing Data image
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 Testing Data #2 of anti-GRIN1 antibody    anti-GRIN1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for GRIN1. It may not necessarily be applicable to this product.
 NCBI GI #    548377
 NCBI GeneID    2902
 NCBI Accession #    Q05586.1 [Other Products]
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 UniProt Primary Accession #    Q05586 [Other Products]
 UniProt Secondary Accession #    P35437; Q12867; Q12868; Q5VSF3; Q5VSF4; Q5VSF5; Q5VSF6; Q5VSF7; A6NLK7; A6NLR1; C9K0X1 [Other Products]
 UniProt Related Accession #    Q05586 [Other Products]
 Molecular Weight    101,851 Da
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 NCBI Official Full Name    Glutamate receptor ionotropic, NMDA 1
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, N-methyl D-aspartate 1
 NCBI Official Symbol    GRIN1 [Similar Products]
 NCBI Official Synonym Symbols   
NR1; MRD8; GluN1; NMDA1; NMDAR1
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 1; NMD-R1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 1
 UniProt Synonym Protein Names   
Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIN1 [Similar Products]
 UniProt Synonym Gene Names    NMDAR1; GluN1; NMD-R1 [Similar Products]
 UniProt Entry Name    NMDZ1_HUMAN
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 NCBI Summary for GRIN1    The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIN1    NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: neuron projection; cell surface; endoplasmic reticulum; integral to plasma membrane; postsynaptic density; dendrite; dendritic spine; terminal button; excitatory synapse; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; plasma membrane; synapse; cell junction

Molecular Function: voltage-gated cation channel activity; neurotransmitter binding; glutamate receptor binding; calcium channel activity; calcium ion binding; calmodulin binding; protein binding; enzyme binding; glutamate binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding

Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; male mating behavior; prepulse inhibition; adult locomotory behavior; positive regulation of apoptosis; regulation of dendrite morphogenesis; rhythmic process; response to morphine; sensory perception of pain; regulation of axonogenesis; calcium ion homeostasis; synaptic transmission; regulation of respiratory gaseous exchange; conditioned taste aversion; ephrin receptor signaling pathway; visual learning; negative regulation of neuron apoptosis; protein tetramerization; cation transport; synaptic transmission, glutamatergic; response to amphetamine; social behavior; respiratory gaseous exchange; pons maturation; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; regulation of synaptogenesis; olfactory learning; long-term memory; suckling behavior; propylene metabolic process; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; regulation of excitatory postsynaptic membrane potential; response to calcium ion

Disease: Mental Retardation, Autosomal Dominant 8
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 Research Articles on GRIN1    1. the levels were comparable for complexes containing GluR2, GluR3 and GluR4 as well as 5-HT1A. Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 were significantly increased in male patients with AD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GRIN1 antibodyDiseases associated with anti-GRIN1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >28 publications with GRIN1 and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with GRIN1 and Brain Diseases
 Disease Models, Animal Antibodies  >10 publications with GRIN1 and Disease Models, Animal
 Memory Disorders Antibodies  >7 publications with GRIN1 and Memory Disorders
 Nerve Degeneration Antibodies  >6 publications with GRIN1 and Nerve Degeneration
 Movement Disorders Antibodies  >5 publications with GRIN1 and Movement Disorders
 Pain Antibodies  >5 publications with GRIN1 and Pain
 Poisoning Antibodies  >4 publications with GRIN1 and Poisoning
 Learning Disorders Antibodies  >4 publications with GRIN1 and Learning Disorders
 Seizures Antibodies  >3 publications with GRIN1 and Seizures
Organs/Tissues associated with anti-GRIN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >70 publications with GRIN1 and Brain
 Nerve Antibodies  >62 publications with GRIN1 and Nerve
 Eye Antibodies  >2 publications with GRIN1 and Eye
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