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anti-GRIN2B antibody :: Goat NMDAR2B/GRIN2B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420388
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NMDAR2B/GRIN2B, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-NMDAR2B/GRIN2B Antibody

 Product Synonym Names    GRIN2B; NMDAR2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; HGNC: 4586; NR2B; hNR3; N-methyl-D-aspartate receptor subunit 2B; GRIN2B antibody; NMDAR2B antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 2B antibody; HGNC: 4586 antibody; NR2B antibody; hNR3 antibody; N-methyl-D-aspartate receptor subunit 2B antibody; NMDAR2B / GRIN2B
 Product Gene Name   

anti-GRIN2B antibody

[Similar Products]
 Product Synonym Gene Name    NMDAR2B [Similar Products]
 Antibody/Peptide Pairs    NMDAR2B / GRIN2B peptide (MBS425235) is used for blocking the activity of NMDAR2B/GRIN2B antibody (MBS420388)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KDAHEKDDFH HLS
 OMIM    138252
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KDAHEKDDFHHLS, from the internal region of the protein sequence according to NP_000825.1.
 Epitope    Internal region
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1469
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GRIN2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GRIN2B antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GRIN2B antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 170kDa band observed in Rat Brain lysates (calculated MW of 166kDa according to NP_000825.1). Recommended concentration: 2-4ug/ml.
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 Western Blot (WB) of anti-GRIN2B antibody    (2ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GRIN2B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GRIN2B. It may not necessarily be applicable to this product.
 NCBI GI #    4504127
 NCBI GeneID    2904
 NCBI Accession #    NP_000825.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000834.2 [Other Products]
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 UniProt Secondary Accession #    Q12919; Q13220; Q13225; Q14CU4; Q9UM56 [Other Products]
 UniProt Related Accession #    Q13224 [Other Products]
 Molecular Weight    166,367 Da
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 NCBI Official Full Name    N-methyl-D-aspartate receptor subunit 2B
 NCBI Official Synonym Full Names    glutamate ionotropic receptor NMDA type subunit 2B
 NCBI Official Symbol    GRIN2B [Similar Products]
 NCBI Official Synonym Symbols   
MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 2B
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 2B
 UniProt Synonym Protein Names   
Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIN2B [Similar Products]
 UniProt Synonym Gene Names    NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3 [Similar Products]
 UniProt Entry Name    NMDE2_HUMAN
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 NCBI Summary for GRIN2B    N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIN2B    NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: cell junction; cell surface; integral to plasma membrane; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane

Molecular Function: extracellular-glutamate-gated ion channel activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding

Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; positive regulation of GTPase activity; response to ethanol; synaptic transmission; transport

Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6
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 Research Articles on GRIN2B    1. GRIN2B encodes the NR2 subunit of NMDA receptors, which are a class of ionotropic glutamate receptors involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRIN2B antibodyPathways associated with anti-GRIN2B antibody
 Reference Product  PubMed Publications
 GRIN1 antibody  >33 publications with GRIN2B and GRIN1
 DLG4 antibody  >4 publications with GRIN2B and DLG4
 CAMK2G antibody  >2 publications with GRIN2B and CAMK2G
 CAMK2A antibody  >2 publications with GRIN2B and CAMK2A
 RASGRF1 antibody  >1 publications with GRIN2B and RASGRF1
 FYN antibody  >1 publications with GRIN2B and FYN
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
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 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
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Diseases associated with anti-GRIN2B antibodyOrgans/Tissues associated with anti-GRIN2B antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >51 publications with GRIN2B and Schizophrenia
 Nervous System Diseases Antibodies  >49 publications with GRIN2B and Nervous System Diseases
 Brain Diseases Antibodies  >30 publications with GRIN2B and Brain Diseases
 Movement Disorders Antibodies  >15 publications with GRIN2B and Movement Disorders
 Neurobehavioral Manifestations Antibodies  >14 publications with GRIN2B and Neurobehavioral Manifestations
 Substance-Related Disorders Antibodies  >13 publications with GRIN2B and Substance-Related Disorders
 Anxiety Disorders Antibodies  >12 publications with GRIN2B and Anxiety Disorders
 Cognition Disorders Antibodies  >12 publications with GRIN2B and Cognition Disorders
 Epilepsy Antibodies  >11 publications with GRIN2B and Epilepsy
 Learning Disorders Antibodies  >10 publications with GRIN2B and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >90 publications with GRIN2B and Brain
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