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anti-NME2 antibody :: Rabbit NME2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9125304
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NME2, Polyclonal Antibody

 Also Known As   

NME2

 Product Gene Name   

anti-NME2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    156491
 3D Structure    ModBase 3D Structure for P22392
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Species    Human
 Immunogen    Recombinant Protein
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 Other Notes    Small volumes of anti-NME2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NME2 antibody    Polyclonal
 Applications Tested/Suitable for anti-NME2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-NME2 antibody    Western blot analysis of extracts of various cell lines, using NME2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
anti-NME2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NME2 antibody    Immunohistochemistry of paraffin-embedded human kidney using NME2 antibody at dilution of 1:100 (40x lens).
anti-NME2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NME2 antibody    Immunohistochemistry of paraffin-embedded mouse kidney using NME2 antibody at dilution of 1:100 (40x lens).
anti-NME2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-NME2 antibody    Immunofluorescence analysis of A549 cells using NME2 antibody. Blue: DAPI for nuclear staining.
anti-NME2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for NME2. It may not necessarily be applicable to this product.
 NCBI GI #    127983
 NCBI GeneID    4831
 NCBI Accession #    P22392.1 [Other Products]
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 UniProt Primary Accession #    P22392 [Other Products]
 UniProt Secondary Accession #    Q1WM23; Q6LCT6; A8MWA3 [Other Products]
 UniProt Related Accession #    P22392 [Other Products]
 Molecular Weight    152
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 NCBI Official Full Name    Nucleoside diphosphate kinase B
 NCBI Official Synonym Full Names    NME/NM23 nucleoside diphosphate kinase 2
 NCBI Official Symbol    NME2 [Similar Products]
 NCBI Official Synonym Symbols   
PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
[Similar Products]
 NCBI Protein Information    nucleoside diphosphate kinase B; HEL-S-155an; NDP kinase B; c-myc transcription factor; histidine protein kinase NDKB; nucleotide diphosphate kinase B; c-myc purine-binding transcription factor PUF; epididymis secretory sperm binding protein Li 155an; non-metastatic cells 2, protein (NM23) expressed in; non-metastatic cells 2, protein (NM23B) expressed in
 UniProt Protein Name    Nucleoside diphosphate kinase B
 UniProt Synonym Protein Names   
C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2
 UniProt Gene Name    NME2 [Similar Products]
 UniProt Synonym Gene Names    NM23B; NDK B; NDP kinase B [Similar Products]
 UniProt Entry Name    NDKB_HUMAN
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 NCBI Summary for NME2    Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
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 UniProt Comments for NME2    NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; EC 2.7.4.6; Nucleotide Metabolism - pyrimidine; Kinase, other; Kinase, nucleoside diphosphate; EC 2.7.13.3; Nucleotide Metabolism - purine; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: ruffle; centrosome; focal adhesion; mitochondrion; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; intermediate filament; nucleus; cytosol

Molecular Function: protein binding; gamma-tubulin binding; metal ion binding; protein histidine kinase activity; intermediate filament binding; nucleoside diphosphate kinase activity; protein kinase binding; transcription factor activity; single-stranded DNA binding; ATP binding

Biological Process: integrin-mediated signaling pathway; GTP biosynthetic process; peptidyl-histidine phosphorylation; response to cAMP; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of myeloid leukocyte differentiation; UTP biosynthetic process; hippocampus development; nucleoside diphosphate phosphorylation; response to testosterone stimulus; CTP biosynthetic process; regulation of transcription, DNA-dependent; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; cell adhesion; regulation of epidermis development; positive regulation of epithelial cell proliferation; response to amine stimulus; positive regulation of keratinocyte differentiation; purine nucleotide metabolic process; negative regulation of apoptosis
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 Research Articles on NME2    1. NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NME2 antibodyDiseases associated with anti-NME2 antibody
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >10 publications with NME2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >5 publications with NME2 and Breast Neoplasms
 Disease Models, Animal Antibodies  >5 publications with NME2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >4 publications with NME2 and Lung Neoplasms
 Liver Diseases Antibodies  >3 publications with NME2 and Liver Diseases
 Ovarian Neoplasms Antibodies  >3 publications with NME2 and Ovarian Neoplasms
 Anemia Antibodies  >3 publications with NME2 and Anemia
 Neoplasms, Experimental Antibodies  >3 publications with NME2 and Neoplasms, Experimental
 Lung Diseases Antibodies  >3 publications with NME2 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with NME2 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-NME2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with NME2 and Blood
 Lung Antibodies  >11 publications with NME2 and Lung
 Brain Antibodies  >8 publications with NME2 and Brain
 Liver Antibodies  >7 publications with NME2 and Liver
 Bone Marrow Antibodies  >6 publications with NME2 and Bone Marrow
 Heart Antibodies  >6 publications with NME2 and Heart
 Bone Antibodies  >6 publications with NME2 and Bone
 Muscle Antibodies  >5 publications with NME2 and Muscle
 Embryonic Tissue Antibodies  >4 publications with NME2 and Embryonic Tissue
 Vascular Antibodies  >3 publications with NME2 and Vascular
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