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anti-NME2 antibody :: Rabbit anti-Human, Mouse NME2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9407020
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NME2, Polyclonal Antibody

★Popular Item★
 Also Known As   

NME2 Antibody

 Product Synonym Names    PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
 Product Gene Name   

anti-NME2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    156491
 3D Structure    ModBase 3D Structure for P22392
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody detects endogenous levels of total NME2 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
 Concentration    2.8 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide corresponding to residues near the C terminal of human NME/NM23 nucleoside diphosphate kinase 2
 Target Name    NME2
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-NME2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NME2 antibody

   Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product.
 Product Categories/Family for anti-NME2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-NME2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-NME2 antibody    Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:30-1:150
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 Testing Data of anti-NME2 antibody    Gel: 12%SDS-PAGE Lysates (from left to right): Hela, NIH/3T3, lncap and 293T cell, mouse brain tissue, A549 and Jurkat cell Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000Exposure time: 30 seconds
anti-NME2 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-NME2 antibody    Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/40.
anti-NME2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NME2. It may not necessarily be applicable to this product.
 NCBI GI #    66392203
 NCBI GeneID    654364
 NCBI Accession #    NP_001018146.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018136.2 [Other Products]
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 UniProt Primary Accession #    P22392 [Other Products]
 UniProt Secondary Accession #    Q1WM23; Q6LCT6; A8MWA3 [Other Products]
 Molecular Weight    17kDa
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 NCBI Official Full Name    NME1-NME2 protein
 NCBI Official Synonym Full Names    NME1-NME2 readthrough
 NCBI Official Symbol    NME1-NME2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    NME1-NME2 protein
 UniProt Protein Name    Nucleoside diphosphate kinase B
 UniProt Synonym Protein Names   
C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:; nm23-H2
 UniProt Gene Name    NME2 [Similar Products]
 UniProt Synonym Gene Names    NM23B; NDK B; NDP kinase B [Similar Products]
 UniProt Entry Name    NDKB_HUMAN
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 NCBI Summary for NME2    This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
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 UniProt Comments for NME2    NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Kinase, other; Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator; EC; EC; Kinase, nucleoside diphosphate; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: ruffle; centrosome; focal adhesion; mitochondrion; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; intermediate filament; nucleus; cytosol

Molecular Function: protein binding; gamma-tubulin binding; metal ion binding; protein histidine kinase activity; intermediate filament binding; nucleoside diphosphate kinase activity; protein kinase binding; transcription factor activity; ATP binding; single-stranded DNA binding

Biological Process: integrin-mediated signaling pathway; GTP biosynthetic process; peptidyl-histidine phosphorylation; response to cAMP; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; UTP biosynthetic process; negative regulation of myeloid leukocyte differentiation; hippocampus development; nucleoside diphosphate phosphorylation; response to testosterone stimulus; CTP biosynthetic process; regulation of transcription, DNA-dependent; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; cell adhesion; regulation of epidermis development; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; purine nucleotide metabolic process; negative regulation of apoptosis; response to amine stimulus
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 Research Articles on NME2    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NME2 antibodyPathways associated with anti-NME2 antibody
 Reference Product  PubMed Publications
 NME1 antibody  >2 publications with NME2 and NME1
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 CMP Phosphorylation Pathway antibodies  CMP Phosphorylation Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies  Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
Diseases associated with anti-NME2 antibodyOrgans/Tissues associated with anti-NME2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with NME2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with NME2 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with NME2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with NME2 and Lung
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