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anti-NOD2 antibody :: Rabbit anti-Human NOD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150816
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NOD2, Polyclonal Antibody

 Also Known As   

NOD2 Antibody

 Product Synonym Names    NOD2; CD; ACUG; BLAU; IBD1; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1; Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; nucleotide-binding oligomerization domain containing 2
 Product Gene Name   

anti-NOD2 antibody

[Similar Products]
 Antibody/Peptide Pairs    NOD2 peptide (MBS152977) is used for blocking the activity of NOD2 antibody (MBS150816)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609464
 3D Structure    ModBase 3D Structure for Q9HC29
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    NOD2 has no cross-reaction with NOD1.
 Purity/Purification    NOD2 Antibody is immunoaffinity chromatography purified IgG.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    Rabbit NOD2 polyclonal antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2.
 Buffer    NOD2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    NOD2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-NOD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOD2 antibody

   NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.
 Applications Tested/Suitable for anti-NOD2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NOD2 antibody    NOD2 antibody can be used for detection of Noxa by Western blot at 1 to 4 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 10 mug/mL.
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 Western Blot (WB) of anti-NOD2 antibody    Western blot analysis of NOD2 in Jurkat cell lysate with NOD2 antibody at (A) 1, (B) 2 and (C) 4 μg/mL.
anti-NOD2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-NOD2 antibody    Immunocytochemistry of NOD2 in Jurkat cells with NOD2 antibody at 5 μg/mL.
anti-NOD2 antibody Immunocytochemistry (ICC) (ICC) image
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 Immunofluorescence (IF) of anti-NOD2 antibody    Immunofluorescence of NOD2 in Jurkat cells with NOD2 antibody at 20 μg/mL.
anti-NOD2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for NOD2. It may not necessarily be applicable to this product.
 NCBI GI #    20137973
 NCBI GeneID    64127
 NCBI Accession #    Q9HC29.1 [Other Products]
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 UniProt Primary Accession #    Q9HC29 [Other Products]
 UniProt Secondary Accession #    Q96RH5; Q96RH6; Q96RH8; E2JEQ6 [Other Products]
 UniProt Related Accession #    Q9HC29 [Other Products]
 Molecular Weight    22,403 Da
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 NCBI Official Full Name    Nucleotide-binding oligomerization domain-containing protein 2
 NCBI Official Synonym Full Names    nucleotide-binding oligomerization domain containing 2
 NCBI Official Symbol    NOD2 [Similar Products]
 NCBI Official Synonym Symbols   
CD; ACUG; BLAU; IBD1; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1
[Similar Products]
 NCBI Protein Information    nucleotide-binding oligomerization domain-containing protein 2; NOD-like receptor C2; NLR family, CARD domain containing 2; inflammatory bowel disease protein 1; caspase recruitment domain protein 15; nucleotide-binding oligomerization domain 2; caspase recruitment domain family, member 15; caspase recruitment domain-containing protein 15; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
 UniProt Protein Name    Nucleotide-binding oligomerization domain-containing protein 2
 UniProt Synonym Protein Names   
Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1
 Protein Family    Nucleotide-binding oligomerization domain-containing protein
 UniProt Gene Name    NOD2 [Similar Products]
 UniProt Synonym Gene Names    CARD15; IBD1 [Similar Products]
 UniProt Entry Name    NOD2_HUMAN
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 NCBI Summary for NOD2    This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
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 UniProt Comments for NOD2    NOD2: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash. Defects in NOD2 are a cause of susceptibility to inflammatory bowel disease type 1 (IBD1). IBD1 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Defects in NOD2 are the cause of sarcoidosis early-onset (EOS). EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early- onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement. 2 isoforms of the human protein are produced by alternative initiation.

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: signalosome; cell surface; protein complex; cytoskeleton; cytoplasm; plasma membrane; cytosol; vesicle

Molecular Function: protein binding; peptidoglycan binding; enzyme binding; CARD domain binding; protein kinase binding; ATP binding; muramyl dipeptide binding

Biological Process: activation of MAPK activity; positive regulation of dendritic cell antigen processing and presentation; maintenance of gastrointestinal epithelium; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; negative regulation of interleukin-2 production; toll-like receptor 5 signaling pathway; positive regulation of gamma-delta T cell activation; positive regulation of phagocytosis; JNK cascade; detection of muramyl dipeptide; cytokine production during immune response; detection of biotic stimulus; toll-like receptor 4 signaling pathway; positive regulation of oxidoreductase activity; positive regulation of interleukin-17 production; negative regulation of interleukin-12 production; positive regulation of T-helper 2 type immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of dendritic cell cytokine production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; protein oligomerization; negative regulation of interleukin-18 production; toll-like receptor 2 signaling pathway; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; innate immune response in mucosa; response to muramyl dipeptide; inhibition of NF-kappaB transcription factor; positive regulation of B cell activation; defense response to bacterium; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of epithelial cell proliferation; negative regulation of T cell mediated immunity; positive regulation of nitric-oxide synthase biosynthetic process; detection of bacterium; positive regulation of interleukin-12 production; positive regulation of JNK cascade; defense response; positive regulation of stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; response to exogenous dsRNA; negative regulation of interferon-gamma production; negative regulation of inflammatory response to antigenic stimulus; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; positive regulation of Notch signaling pathway; response to nutrient; positive regulation of humoral immune response mediated by circulating immunoglobulin; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase activity; negative regulation of tumor necrosis factor production; immunoglobulin production during immune response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-1 beta production; regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response

Disease: Psoriatic Arthritis, Susceptibility To; Sarcoidosis, Early-onset; Inflammatory Bowel Disease 1; Blau Syndrome
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 Research Articles on NOD2    1. The mutated NOD2 R702W genotype in the recipient is independently associated with an increased risk of bacterial infections after liver transplantation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOD2 antibodyPathways associated with anti-NOD2 antibody
 Reference Product  PubMed Publications
 TNF antibody  >218 publications with NOD2 and TNF
 ATG16L1 antibody  >141 publications with NOD2 and ATG16L1
 RIPK2 antibody  >107 publications with NOD2 and RIPK2
 CASP1 antibody  >61 publications with NOD2 and CASP1
 ERBB2IP antibody  >4 publications with NOD2 and ERBB2IP
 IKBKG antibody  >3 publications with NOD2 and IKBKG
 TRIM27 antibody  >1 publications with NOD2 and TRIM27
 RIPK1 antibody  >1 publications with NOD2 and RIPK1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 JNK (c-Jun Kinases) Phosphorylation And Activation Mediated By Activated Human TAK1 Pathway antibodies  JNK (c-Jun Kinases) Phosphorylation And Activation Mediated By Activated Human TAK1 Pathway Diagram
 MAP Kinase Activation In TLR Cascade Pathway antibodies  MAP Kinase Activation In TLR Cascade Pathway Diagram
Diseases associated with anti-NOD2 antibodyOrgans/Tissues associated with anti-NOD2 antibody
 Disease Name  Pubmed Publications
 Inflammatory Bowel Diseases Antibodies  >1129 publications with NOD2 and Inflammatory Bowel Diseases
 Crohn Disease Antibodies  >913 publications with NOD2 and Crohn Disease
 Inflammation Antibodies  >598 publications with NOD2 and Inflammation
 Colitis Antibodies  >480 publications with NOD2 and Colitis
 Colitis, Ulcerative Antibodies  >385 publications with NOD2 and Colitis, Ulcerative
 Necrosis Antibodies  >264 publications with NOD2 and Necrosis
 Sarcoidosis Antibodies  >63 publications with NOD2 and Sarcoidosis
 Sepsis Antibodies  >45 publications with NOD2 and Sepsis
 Liver Diseases Antibodies  >39 publications with NOD2 and Liver Diseases
 Pneumonia Antibodies  >25 publications with NOD2 and Pneumonia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >454 publications with NOD2 and Blood
 Intestine Antibodies  >328 publications with NOD2 and Intestine
 Skin Antibodies  >77 publications with NOD2 and Skin
 Lung Antibodies  >72 publications with NOD2 and Lung
 Kidney Antibodies  >53 publications with NOD2 and Kidney
 Spleen Antibodies  >43 publications with NOD2 and Spleen
 Brain Antibodies  >30 publications with NOD2 and Brain
 Heart Antibodies  >23 publications with NOD2 and Heart
 Muscle Antibodies  >18 publications with NOD2 and Muscle
 Placenta Antibodies  >6 publications with NOD2 and Placenta
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