NP_001188412.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
c-myc promoter-binding protein-1 isoform MBP-1
NCBI Official Synonym Full Names
enolase 1, (alpha)
NCBI Protein Information
alpha-enolase; c-myc promoter-binding protein-1; 2-phospho-D-glycerate hydro-lyase; MYC promoter-binding protein 1; alpha enolase like 1; enolase-alpha; non-neural enolase; phosphopyruvate hydratase; plasminogen-binding protein; tau-crystallin
UniProt Protein Name
Alpha-enolase
UniProt Synonym Protein Names
2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
ENOA_HUMAN
NCBI Summary for ENO1
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
UniProt Comments for ENO1
ENO1: an abundant cytoplasmic enzyme with 2-phospho-D-glycerate hydro-lyase activity. A target of excess protein nitration in Alzheimer disease (AD) brain. Tau-crystallin, a structural lens protein, is produced from an alternative translation start in the enolase gene.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Transcription, coactivator/corepressor; Lyase
Chromosomal Location of Human Ortholog: 1p36.2
Cellular Component: extracellular space; phosphopyruvate hydratase complex; membrane; cytoplasm; plasma membrane; M band; cytosol; nucleus
Molecular Function: protein binding; DNA binding; magnesium ion binding; phosphopyruvate hydratase activity; transcription factor activity; transcription corepressor activity
Biological Process: glycolysis; transcription, DNA-dependent; response to virus; carbohydrate metabolic process; glucose metabolic process; pathogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; gluconeogenesis
Research Articles on ENO1
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Pathways associated with anti-ENO1 antibody
Diseases associated with anti-ENO1 antibody
Disease Name |
Pubmed Publications |
Carcinoma Antibodies |
>38 publications with ENO1 and Carcinoma |
Lung Neoplasms Antibodies |
>22 publications with ENO1 and Lung Neoplasms |
Disease Models, Animal Antibodies |
>15 publications with ENO1 and Disease Models, Animal |
Adenocarcinoma Antibodies |
>15 publications with ENO1 and Adenocarcinoma |
Arthritis, Rheumatoid Antibodies |
>14 publications with ENO1 and Arthritis, Rheumatoid |
Breast Neoplasms Antibodies |
>14 publications with ENO1 and Breast Neoplasms |
Inflammation Antibodies |
>13 publications with ENO1 and Inflammation |
Carcinoma, Non-Small-Cell Lung Antibodies |
>12 publications with ENO1 and Carcinoma, Non-Small-Cell Lung |
Neoplasms, Experimental Antibodies |
>9 publications with ENO1 and Neoplasms, Experimental |
Carcinoma, Squamous Cell Antibodies |
>7 publications with ENO1 and Carcinoma, Squamous Cell |
Organs/Tissues associated with anti-ENO1 antibody
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