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anti-NOS2 antibody :: Rabbit NOS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2523872
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NOS2, Polyclonal Antibody

★Popular Item★
 Also Known As   

NOS2 Polyclonal Antibody

 Product Synonym Names    NOS; INOS; NOS2A; HEP-NOS
 Product Gene Name   

anti-NOS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163730
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.4mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human NOS2
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOS2 antibody

   Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
 Product Categories/Family for anti-NOS2 antibody    Cancer; Epigenetics
 Applications Tested/Suitable for anti-NOS2 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-NOS2 antibody    IHC: 1:10-1:50
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 Immunohistochemistry (IHC) of anti-NOS2 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using NOS2 Polyclonal Antibody at dilution 1:20
anti-NOS2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NOS2. It may not necessarily be applicable to this product.
 NCBI GI #    24041029
 NCBI GeneID    4843
 NCBI Accession #    NP_000616.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000625.4 [Other Products]
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 UniProt Secondary Accession #    O60757; O94994; Q16263; Q16692; Q4TTS5; Q9UD42; A1L3U5; B7ZLY2 [Other Products]
 UniProt Related Accession #    P35228 [Other Products]
 Molecular Weight    126,749 Da
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 NCBI Official Full Name    nitric oxide synthase, inducible
 NCBI Official Synonym Full Names    nitric oxide synthase 2, inducible
 NCBI Official Symbol    NOS2 [Similar Products]
 NCBI Official Synonym Symbols   
NOS; INOS; NOS2A; HEP-NOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, inducible; NOS type II; NOS, type II; hepatocyte NOS; inducible NO synthase; inducible NOS; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2
 UniProt Protein Name    Nitric oxide synthase, inducible
 UniProt Synonym Protein Names   
Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
 Protein Family    Nitric oxide synthase
 UniProt Gene Name    NOS2 [Similar Products]
 UniProt Synonym Gene Names    NOS2A; HEP-NOS; Inducible NOS; iNOS [Similar Products]
 UniProt Entry Name    NOS2_HUMAN
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 NCBI Summary for NOS2    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NOS2    iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Homodimer. Binds SLC9A3R1. By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Belongs to the NOS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.14.13.39

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cortical cytoskeleton; perinuclear region of cytoplasm; cytoplasm; peroxisome; intracellular; cytosol; nucleus

Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; FAD binding; NADPH-hemoprotein reductase activity; FMN binding; nitric-oxide synthase activity; iron ion binding; heme binding; NADP binding; receptor binding

Biological Process: circadian rhythm; interaction with host; superoxide metabolic process; positive regulation of guanylate cyclase activity; positive regulation of killing of cells of another organism; defense response to Gram-negative bacterium; positive regulation of vasodilation; regulation of cell proliferation; regulation of cellular respiration; positive regulation of leukocyte mediated cytotoxicity; innate immune response in mucosa; response to bacterium; defense response to bacterium; peptidyl-cysteine S-nitrosylation; response to hypoxia; arginine catabolic process; negative regulation of blood pressure; negative regulation of protein catabolic process; blood coagulation; nitric oxide biosynthetic process; inflammatory response; regulation of insulin secretion; nitric oxide mediated signal transduction

Disease: Hypertension, Essential; Malaria, Susceptibility To
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 Research Articles on NOS2    1. Several common haplotypes in the NOS2 gene contribute to variation in fractional exhaled nitric oxide in adults.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NOS2 antibodyDiseases associated with anti-NOS2 antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2537 publications with NOS2 and Inflammation
 Necrosis Antibodies  >2070 publications with NOS2 and Necrosis
 Sepsis Antibodies  >579 publications with NOS2 and Sepsis
 Intestinal Diseases Antibodies  >419 publications with NOS2 and Intestinal Diseases
 Liver Diseases Antibodies  >386 publications with NOS2 and Liver Diseases
 Reperfusion Injury Antibodies  >385 publications with NOS2 and Reperfusion Injury
 Hypertension Antibodies  >299 publications with NOS2 and Hypertension
 Endotoxemia Antibodies  >262 publications with NOS2 and Endotoxemia
 Shock, Septic Antibodies  >251 publications with NOS2 and Shock, Septic
 Kidney Diseases Antibodies  >228 publications with NOS2 and Kidney Diseases
Organs/Tissues associated with anti-NOS2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2729 publications with NOS2 and Blood
 Brain Antibodies  >1137 publications with NOS2 and Brain
 Lung Antibodies  >869 publications with NOS2 and Lung
 Intestine Antibodies  >507 publications with NOS2 and Intestine
 Pancreas Antibodies  >226 publications with NOS2 and Pancreas
 Stomach Antibodies  >221 publications with NOS2 and Stomach
 Connective Tissue Antibodies  >100 publications with NOS2 and Connective Tissue
 Embryonic Tissue Antibodies  >90 publications with NOS2 and Embryonic Tissue
 Mixed Antibodies  >76 publications with NOS2 and Mixed
 Ovary Antibodies  >48 publications with NOS2 and Ovary
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