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anti-NOX1 antibody :: Rabbit anti-Mouse, Rat NOX1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175538
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NOX1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-NOX1 antibody

 Product Synonym Names    NADPH oxidase 1(NOX-1); NADPH oxidase 1; GP91 2 antibody; Mitogenic oxidase(pyridine nucleotide dependent superoxide generating) antibody; Mitogenic oxidase 1 antibody; MOX-1 antibody; MOX1 antibody; NADH/NADPH mitogenic oxidase subunit P65 MOX antibody; NADH/NADPH mitogenic oxidase subunit P65-MOX antibody; NADPH oxidase 1 antibody; NADPH oxidase 1 variant NOH 1L antibody; NADPH oxidase homolog 1 antibody; NOH 1 antibody; NOH-1 antibody; NOH1 antibody; NOX-1 antibody; Nox1 antibody; NOX1_HUMAN antibody; RP1 146H21.1 antibody
 Product Gene Name   

anti-NOX1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9WV87
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of rat NOX1 (417-431aa WYKFQRAHNKLKTQK), different from the related mouse sequence by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NOX1 antibody

   Description: Rabbit IgG polyclonal antibody for NADPH oxidase 1(NOX1) detection. Tested with WB, IHC-P in Mouse, Rat.
Background: NOX1(NADPH OXIDASE 1), also known as NOH1, MOX1 or GP91-2, is an enzyme that in humans is encoded by the NOX1 gene. It is also a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. The NOX1 gene is mapped to Xq22.1. NOX1 was expressed in colon, prostate, uterus, and vascular smooth muscle, but not in peripheral blood leukocytes. The deduced 564-amino acid NOX1 protein, which is 58% identical to CYBB, contains 6 membrane-spanning regions, conserved flavin and pyridine nucleotide-binding sites, and histidines possibly involved in heme ligation. Overexpression of MOX1 in NIH 3T3 cells increased superoxide generation and cell growth. Cells expressing MOX1 had a transformed appearance, showed anchorage-independent growth, and produced tumors in athymic mice. Disruption of either Nox1 or Nox2 significantly delayed progression of motor neuron disease in these mice. However, 50% survival rates were enhanced significantly more by Nox2 deletion than Nox1 deletion.
 Applications Tested/Suitable for anti-NOX1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Testing Data of anti-NOX1 antibody    anti-NOX1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NOX1. It may not necessarily be applicable to this product.
 NCBI GI #    8134593
 NCBI GeneID    114243
 NCBI Accession #    Q9WV87.1 [Other Products]
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 UniProt Primary Accession #    Q9WV87 [Other Products]
 UniProt Related Accession #    Q9WV87 [Other Products]
 Molecular Weight    65,177 Da
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 NCBI Official Full Name    NADPH oxidase 1
 NCBI Official Synonym Full Names    NADPH oxidase 1
 NCBI Official Symbol    Nox1 [Similar Products]
 NCBI Protein Information    NADPH oxidase 1; MOX1; MOX-1; NOH-1; NOX-1; mitogenic oxidase 1; NADH/NADPH mitogenic oxidase subunit p65-mox
 UniProt Protein Name    NADPH oxidase 1
 UniProt Synonym Protein Names   
Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1
 Protein Family    NADPH oxidase
 UniProt Gene Name    Nox1 [Similar Products]
 UniProt Synonym Gene Names    Mox1; Noh1; NOX-1; MOX-1 [Similar Products]
 UniProt Entry Name    NOX1_RAT
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 NCBI Summary for NOX1    involved in superoxide generation and serum-stimulated growth [RGD, Feb 2006]
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 UniProt Comments for NOX1    NOX1: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, misc.; Motility/polarity/chemotaxis; Oxidoreductase; Membrane protein, multi-pass; Membrane protein, integral; EC 1.-.-.-

Cellular Component: cytoplasm; early endosome; cell junction; endosome; NADPH oxidase complex

Molecular Function: protein binding; superoxide-generating NADPH oxidase activity; metal ion binding; Rac GTPase binding; voltage-gated proton channel activity

Biological Process: intracellular pH elevation; cell migration; extracellular matrix organization and biogenesis; positive regulation of smooth muscle cell proliferation; superoxide metabolic process; positive regulation of JNK cascade; signal transduction; regulation of systemic arterial blood pressure by renin-angiotensin; proton transport; response to reactive oxygen species; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; hydrogen peroxide metabolic process; positive regulation of integrin biosynthetic process; angiogenesis; superoxide release
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 Research Articles on NOX1    1. In conclusion, B. trimera extracts exert antioxidant properties by scavenging ROS and decrease the expression of genes responsible by reactive species production in neutrophils.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NOX1 antibodyDiseases associated with anti-NOX1 antibody
 Products by Pathway  Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >142 publications with NOX1 and Cardiovascular Diseases
 Inflammation Antibodies  >105 publications with NOX1 and Inflammation
 Hypertension Antibodies  >99 publications with NOX1 and Hypertension
 Atherosclerosis Antibodies  >62 publications with NOX1 and Atherosclerosis
 Necrosis Antibodies  >49 publications with NOX1 and Necrosis
 Heart Diseases Antibodies  >49 publications with NOX1 and Heart Diseases
 Hypertrophy Antibodies  >45 publications with NOX1 and Hypertrophy
 Nervous System Diseases Antibodies  >37 publications with NOX1 and Nervous System Diseases
 Fibrosis Antibodies  >36 publications with NOX1 and Fibrosis
 Intestinal Diseases Antibodies  >24 publications with NOX1 and Intestinal Diseases
Organs/Tissues associated with anti-NOX1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >5 publications with NOX1 and Eye
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