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anti-NOX4 antibody :: Rabbit NOX4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127001
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NOX4, Polyclonal Antibody

★Popular Item★
 Also Known As   

NOX4 Polyclonal Antibody

 Product Synonym Names    KOX; KOX-1; RENOX
 Product Gene Name   

anti-NOX4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605261
 3D Structure    ModBase 3D Structure for Q9NPH5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human NOX4
 Calculated Molecular Weight    67kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-NOX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOX4 antibody

   NOX4 (NADPH oxidase 4) is a phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes with resultant antimicrobial activity and it has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.NOX4 has 7 isforms and the molecular weight are 7KDa,26-32KDa,58-67KDa,75-80KDa(PMID:11728818).This antibody is specific to NOX4.
 Product Categories/Family for anti-NOX4 antibody    Polyclonal
 Applications Tested/Suitable for anti-NOX4 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NOX4 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-NOX4 antibody    Western blot analysis of extracts of various cell lines, using NOX4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-NOX4 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-NOX4 antibody    Immunofluorescence analysis of HeLa cells using NOX4 antibody. Blue: DAPI for nuclear staining.
anti-NOX4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for NOX4. It may not necessarily be applicable to this product.
 NCBI GI #    212276447
 NCBI GeneID    50507
 NCBI Accession #    Q9NPH5.2 [Other Products]
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 UniProt Primary Accession #    Q9NPH5 [Other Products]
 UniProt Secondary Accession #    Q5K3R4; Q5K3R5; Q5K3R6; Q5K3R8; Q7Z7G3; Q86V92; A8K715; B7Z520; E7EMD7 [Other Products]
 UniProt Related Accession #    Q9NPH5 [Other Products]
 Molecular Weight    578
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 NCBI Official Full Name    NADPH oxidase 4
 NCBI Official Synonym Full Names    NADPH oxidase 4
 NCBI Official Symbol    NOX4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    NADPH oxidase 4; kidney oxidase-1; renal NAD(P)H-oxidase; kidney superoxide-producing NADPH oxidase
 UniProt Protein Name    NADPH oxidase 4
 UniProt Synonym Protein Names   
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase
 Protein Family    NADPH oxidase
 UniProt Gene Name    NOX4 [Similar Products]
 UniProt Synonym Gene Names    RENOX; KOX-1 [Similar Products]
 UniProt Entry Name    NOX4_HUMAN
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 NCBI Summary for NOX4    This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
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 UniProt Comments for NOX4    NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 1.6.3.-; Membrane protein, multi-pass; Cell cycle regulation; Nucleolus; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q14.2-q21

Cellular Component: endoplasmic reticulum membrane; focal adhesion; mitochondrion; perinuclear region of cytoplasm; apical plasma membrane; nucleolus; integral to membrane; stress fiber; NADPH oxidase complex

Molecular Function: oxygen sensor activity; electron carrier activity; FAD binding; NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; nucleotide binding; heme binding

Biological Process: positive regulation of apoptosis; cell morphogenesis; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of MAP kinase activity; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; response to hypoxia; inflammatory response; superoxide release; bone resorption
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 Research Articles on NOX4    1. Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOX4 antibodyPathways associated with anti-NOX4 antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >72 publications with NOX4 and TGFB1
 CYBA antibody  >57 publications with NOX4 and CYBA
 TLR4 antibody  >13 publications with NOX4 and TLR4
 AKT1 antibody  >6 publications with NOX4 and AKT1
 PTPN1 antibody  >6 publications with NOX4 and PTPN1
 SRF antibody  >3 publications with NOX4 and SRF
 VEGFA antibody  >3 publications with NOX4 and VEGFA
 MMP1 antibody  >2 publications with NOX4 and MMP1
 IGFBP3 antibody  >1 publications with NOX4 and IGFBP3
 Products by Pathway  Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Signaling Events Mediated By PTP1B Pathway antibodies  Signaling Events Mediated By PTP1B Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with anti-NOX4 antibodyOrgans/Tissues associated with anti-NOX4 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >256 publications with NOX4 and Cardiovascular Diseases
 Hypertension Antibodies  >168 publications with NOX4 and Hypertension
 Inflammation Antibodies  >158 publications with NOX4 and Inflammation
 Disease Models, Animal Antibodies  >148 publications with NOX4 and Disease Models, Animal
 Fibrosis Antibodies  >139 publications with NOX4 and Fibrosis
 Heart Diseases Antibodies  >109 publications with NOX4 and Heart Diseases
 Atherosclerosis Antibodies  >97 publications with NOX4 and Atherosclerosis
 Kidney Diseases Antibodies  >90 publications with NOX4 and Kidney Diseases
 Hypertrophy Antibodies  >87 publications with NOX4 and Hypertrophy
 Necrosis Antibodies  >63 publications with NOX4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >441 publications with NOX4 and Vascular
 Kidney Antibodies  >193 publications with NOX4 and Kidney
 Brain Antibodies  >55 publications with NOX4 and Brain
 Connective Tissue Antibodies  >40 publications with NOX4 and Connective Tissue
 Eye Antibodies  >32 publications with NOX4 and Eye
 Embryonic Tissue Antibodies  >21 publications with NOX4 and Embryonic Tissue
 Intestine Antibodies  >8 publications with NOX4 and Intestine
 Pancreas Antibodies  >8 publications with NOX4 and Pancreas
 Placenta Antibodies  >5 publications with NOX4 and Placenta
 Mouth Antibodies  >4 publications with NOX4 and Mouth
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