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anti-NOX5 antibody :: Rabbit anti-Human NOX5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176174
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NOX5, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-NOX5 antibody

 Product Synonym Names    NADPH oxidase 5; NADPH oxidase, EF-hand calcium binding domain 5; MGC149776 antibody; MGC149777 antibody; NADPH oxidase 5 antibody; NADPH oxidase EFhand calcium binding domain 5 antibody; NOX5 antibody; NOX5_HUMAN antibody
 Product Gene Name   

anti-NOX5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606572
 3D Structure    ModBase 3D Structure for Q96PH1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human NOX5 (747-765aa KVLKGHCEKFGFRFFQENF).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOX5 antibody

   Description: Rabbit IgG polyclonal antibody for NADPH oxidase 5(NOX5) detection. Tested with WB, IHC-P, ICC in Human.
Background: NOX5(Nadph Oxidase 5), also known as NOX5A or NOX5B, is a protein which in humans is encoded by the NOX5 gene. The International Radiation Hybrid Mapping Consortium mapped the NOX5 gene to chromosome 15. NOX5 is a novel NADPH oxidase that generates superoxide and functions as an H+ channel in a Ca2+-dependent manner. Banfi et al.(2001) found that, when heterologously expressed, NOX5 was quiescent in unstimulated cells. However, in response to elevations of the cytosolic Ca2+ concentration, it generated large amounts of superoxide. Using RT-PCR and Southern and Western blot analyses, Kamiguti et al.(2005) identified NOX5 as a flavin-containing Ca2+-dependent oxidase present in hairy leukemic cells(HC), but not normal B cells.
 Applications Tested/Suitable for anti-NOX5 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

 Application Notes for anti-NOX5 antibody    Western Blot: Concentration: 0.1-0.5ug/ml; Tested Species: Hu
IHC (Paraffin-embedded section): Concentration: 0.5-1ug/ml; Tested Species: Hu; Antigen Retrieval: By Heat.
ICC: Concentration: 0.5-1ug/ml; Tested Species: Hu
Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin sections to 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.
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 Immunohistochemistry (IHC) of anti-NOX5 antibody    Anti-NOX5 antibody, MBS176174, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-NOX5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-NOX5 antibody    Anti-NOX5 antibody, MBS176174, ICC
ICC: HELA Cell
anti-NOX5 antibody Immunocytochemistry (ICC) (ICC) image
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 Western Blot (WB) of anti-NOX5 antibody    Anti-NOX5 antibody, MBS176174, Western blotting
All lanes: Anti (MBS176174) at 0.5ug/ml
Lane 1: 22RV1 Whole Cell Lysate at 40ug
Lane 2: PANC Whole Cell Lysate at 40ug
Lane 3: HELA Whole Cell Lysate at 40ug
Lane 4: SKOV Whole Cell Lysate at 40ug
Predicted bind size: 86KD
Observed bind size: 86KD
anti-NOX5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NOX5. It may not necessarily be applicable to this product.
 NCBI GI #    74717091
 NCBI GeneID    79400
 NCBI Accession #    Q96PH1.1 [Other Products]
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 UniProt Primary Accession #    Q96PH1 [Other Products]
 UniProt Secondary Accession #    Q08AN2; Q08AN3; Q8TEQ1; Q8TER4; Q96PH2; Q96PJ8; Q96PJ9; Q9H6E0; Q9HAM8; B2RBJ4 [Other Products]
 UniProt Related Accession #    Q96PH1 [Other Products]
 Molecular Weight    83,109 Da
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 NCBI Official Full Name    NADPH oxidase 5
 NCBI Official Synonym Full Names    NADPH oxidase, EF-hand calcium binding domain 5
 NCBI Official Symbol    NOX5 [Similar Products]
 NCBI Protein Information    NADPH oxidase 5
 UniProt Protein Name    NADPH oxidase 5
 Protein Family    NADPH oxidase
 UniProt Gene Name    NOX5 [Similar Products]
 UniProt Entry Name    NOX5_HUMAN
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 NCBI Summary for NOX5    This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for NOX5    NOX5: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; EC 1.6.3.-; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; FAD binding; superoxide-generating NADPH oxidase activity; heme binding; calcium ion binding; hydrogen ion channel activity; NADP binding

Biological Process: cell proliferation; proton transport; regulation of fusion of sperm to egg plasma membrane; apoptosis; endothelial cell proliferation; cytokinesis; regulation of proton transport; angiogenesis; cytokine secretion; superoxide release
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 Research Articles on NOX5    1. The study reveals that PKC-alpha is the primary isoform mediating the activation of Nox5.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOX5 antibodyDiseases associated with anti-NOX5 antibody
 Reference Product  PubMed Publications
 NOXA1 antibody  >7 publications with NOX5 and NOXA1
 NOXO1 antibody  >6 publications with NOX5 and NOXO1
 CYBA antibody  >3 publications with NOX5 and CYBA
 SUMO1 antibody  >1 publications with NOX5 and SUMO1
 CD22 antibody  >1 publications with NOX5 and CD22
 HVCN1 antibody  >1 publications with NOX5 and HVCN1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >27 publications with NOX5 and Cardiovascular Diseases
 Inflammation Antibodies  >22 publications with NOX5 and Inflammation
 Hypertension Antibodies  >16 publications with NOX5 and Hypertension
 Adenocarcinoma Antibodies  >13 publications with NOX5 and Adenocarcinoma
 Necrosis Antibodies  >8 publications with NOX5 and Necrosis
 Kidney Diseases Antibodies  >6 publications with NOX5 and Kidney Diseases
 Heart Diseases Antibodies  >5 publications with NOX5 and Heart Diseases
 Lung Diseases Antibodies  >4 publications with NOX5 and Lung Diseases
 Heart Failure Antibodies  >3 publications with NOX5 and Heart Failure
 Hyperglycemia Antibodies  >2 publications with NOX5 and Hyperglycemia
Organs/Tissues associated with anti-NOX5 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >54 publications with NOX5 and Vascular
 Blood Antibodies  >24 publications with NOX5 and Blood
 Lung Antibodies  >12 publications with NOX5 and Lung
 Kidney Antibodies  >12 publications with NOX5 and Kidney
 Testis Antibodies  >6 publications with NOX5 and Testis
 Prostate Antibodies  >5 publications with NOX5 and Prostate
 Skin Antibodies  >2 publications with NOX5 and Skin
 Spleen Antibodies  >2 publications with NOX5 and Spleen
 Brain Antibodies  >2 publications with NOX5 and Brain
 Placenta Antibodies  >1 publications with NOX5 and Placenta
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