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anti-NPC1L1 antibody :: Rabbit anti-Human NPC1L1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9608802
Western Blot (WB)
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NPC1L1, Polyclonal Antibody

★Popular Item★
 Also Known As   

NPC1L1 Antibody

 Product Synonym Names    Niemann Pick C1 like protein 1; Niemann Pick disease type C1 gene like 1; Niemann-Pick C1-like protein 1; NPC1 LIKE 1; NPC1 Niemann Pick disease type C1 gene like 1; NPC1L1; NPC1L1 splice variant; NPCL1_HUMAN; Truncated Niemann Pick C1 like protein 1
 Product Gene Name   

anti-NPC1L1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9UHC9
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    NPC1L1 antibody detects endogenous levels of total NPC1L1
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human NPC1L1
 Subcellular Location    Plasma Membrane
 Tissue Specificity    Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-NPC1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NPC1L1 antibody

   Function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Subunit Structure: Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion. Interacts with NPC2.
Post-translational Modifications: Highly glycosylated.
Similarity: Belongs to the patched family.
 Applications Tested/Suitable for anti-NPC1L1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-NPC1L1 antibody    WB: 1:1000-3000
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 Western Blot (WB) of anti-NPC1L1 antibody    Western blot analysis NPC1L1 using COLO205 whole cell lysates
anti-NPC1L1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NPC1L1. It may not necessarily be applicable to this product.
 NCBI GI #    156231353
 NCBI GeneID    29881
 NCBI Accession #    NP_001095118.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001101648.1 [Other Products]
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 UniProt Primary Accession #    Q9UHC9 [Other Products]
 UniProt Secondary Accession #    Q17RV5; Q6R3Q4; Q9UHC8; A4D2J7; B7ZLE6; D3DVK9 [Other Products]
 UniProt Related Accession #    Q9UHC9 [Other Products]
 Molecular Weight    Observed: 149 kDa
Predicted: 149 kDa
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 NCBI Official Full Name    NPC1-like intracellular cholesterol transporter 1 isoform 2
 NCBI Official Synonym Full Names    NPC1 like intracellular cholesterol transporter 1
 NCBI Official Symbol    NPC1L1 [Similar Products]
 NCBI Official Synonym Symbols   
LDLCQ7; NPC11L1; SLC65A2
[Similar Products]
 NCBI Protein Information    NPC1-like intracellular cholesterol transporter 1
 UniProt Protein Name    NPC1-like intracellular cholesterol transporter 1
 UniProt Synonym Protein Names   
Niemann-Pick C1-like protein 1
 Protein Family    Niemann-Pick C1-like protein
 UniProt Gene Name    NPC1L1 [Similar Products]
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 NCBI Summary for NPC1L1    The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for NPC1L1    Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
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 Research Articles on NPC1L1    1. The results obtained from liver-specific NPC1L1 transgenic mouse (L1-Tg) crossed with LDLR-/- mouse indicated no feedback mechanism to inhibit NPC1L1 function in liver and hepatic expression of NPC1L1 correlated with VLDL secretion in hypercholesterolemia state.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NPC1L1 antibodyPathways associated with anti-NPC1L1 antibody
 Reference Product  PubMed Publications
 ABCG5 antibody  >98 publications with NPC1L1 and ABCG5
 ABCG8 antibody  >76 publications with NPC1L1 and ABCG8
 ABCA1 antibody  >44 publications with NPC1L1 and ABCA1
 SCARB1 antibody  >18 publications with NPC1L1 and SCARB1
 CYP7A1 antibody  >11 publications with NPC1L1 and CYP7A1
 SREBF2 antibody  >9 publications with NPC1L1 and SREBF2
 NPC2 antibody  >8 publications with NPC1L1 and NPC2
 HNF4A antibody  >4 publications with NPC1L1 and HNF4A
 CDC42 antibody  >1 publications with NPC1L1 and CDC42
 PPARA antibody  >1 publications with NPC1L1 and PPARA
 Products by Pathway  Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Trafficking Of Dietary Sterols Pathway antibodies  Trafficking Of Dietary Sterols Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
Diseases associated with anti-NPC1L1 antibodyOrgans/Tissues associated with anti-NPC1L1 antibody
 Disease Name  Pubmed Publications
 Hypercholesterolemia Antibodies  >80 publications with NPC1L1 and Hypercholesterolemia
 Dyslipidemias Antibodies  >76 publications with NPC1L1 and Dyslipidemias
 Hyperlipidemias Antibodies  >62 publications with NPC1L1 and Hyperlipidemias
 Atherosclerosis Antibodies  >56 publications with NPC1L1 and Atherosclerosis
 Liver Diseases Antibodies  >45 publications with NPC1L1 and Liver Diseases
 Fatty Liver Antibodies  >34 publications with NPC1L1 and Fatty Liver
 Brain Diseases Antibodies  >24 publications with NPC1L1 and Brain Diseases
 Inflammation Antibodies  >11 publications with NPC1L1 and Inflammation
 Hepatitis Antibodies  >9 publications with NPC1L1 and Hepatitis
 Fibrosis Antibodies  >8 publications with NPC1L1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >165 publications with NPC1L1 and Liver
 Eye Antibodies  >1 publications with NPC1L1 and Eye
 Pancreas Antibodies  >1 publications with NPC1L1 and Pancreas
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