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anti-NPPB antibody :: Rabbit NPPB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2520594
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NPPB, Polyclonal Antibody

★Popular Item★
 Also Known As   

NPPB Polyclonal Antibody

 Product Synonym Names    BNP
 Product Gene Name   

anti-NPPB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600295
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.8mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human NPPB
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NPPB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NPPB antibody

   This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
 Applications Tested/Suitable for anti-NPPB antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-NPPB antibody    IHC: 1:40-1:150
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 Immunohistochemistry (IHC) of anti-NPPB antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using NPPB Polyclonal Antibody at dilution 1:40
anti-NPPB antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NPPB antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using NPPB Polyclonal Antibody at dilution 1:40
anti-NPPB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NPPB. It may not necessarily be applicable to this product.
 NCBI GI #    4505433
 NCBI GeneID    4879
 NCBI Accession #    NP_002512.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002521.2 [Other Products]
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 UniProt Secondary Accession #    Q6FGY0; Q9P2Q7; B0ZBE9 [Other Products]
 UniProt Related Accession #    P16860 [Other Products]
 Molecular Weight    14,726 Da
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 NCBI Official Full Name    natriuretic peptides B preproprotein
 NCBI Official Synonym Full Names    natriuretic peptide B
 NCBI Official Symbol    NPPB [Similar Products]
 NCBI Official Synonym Symbols   
BNP
[Similar Products]
 NCBI Protein Information    natriuretic peptides B; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic protein
 UniProt Protein Name    Natriuretic peptides B
 UniProt Synonym Protein Names   
Gamma-brain natriuretic peptideCleaved into the following 16 chains:Brain natriuretic peptide 32; BNP(1-32); BNP-32; BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32); BNP(3-30); BNP(3-29); BNP(4-32); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)
 Protein Family    Natriuretic peptides
 UniProt Gene Name    NPPB [Similar Products]
 UniProt Synonym Gene Names    BNP(1-32); BNP-32 [Similar Products]
 UniProt Entry Name    ANFB_HUMAN
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 NCBI Summary for NPPB    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
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 UniProt Comments for NPPB    NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Secreted, signal peptide; Hormone; Secreted

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: extracellular space; protein complex; extracellular region

Molecular Function: diuretic hormone activity; hormone activity; receptor binding

Biological Process: cGMP biosynthetic process; negative regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of vasodilation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; negative regulation of cell growth; regulation of vascular permeability; body fluid secretion; regulation of blood vessel size
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 Research Articles on NPPB    1. Serum NT-proBNP has limited utility as a rule-out test for left ventricular dysfunction in very old people with dyspnea.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NPPB antibodyPathways associated with anti-NPPB antibody
 Reference Product  PubMed Publications
 NPPC antibody  >7 publications with NPPB and NPPC
 MYH6 antibody  >5 publications with NPPB and MYH6
 NPR1 antibody  >5 publications with NPPB and NPR1
 NPR3 antibody  >5 publications with NPPB and NPR3
 NPR2 antibody  >4 publications with NPPB and NPR2
 PLN antibody  >2 publications with NPPB and PLN
 TNNI3 antibody  >2 publications with NPPB and TNNI3
 TNNT2 antibody  >1 publications with NPPB and TNNT2
 IDE antibody  >1 publications with NPPB and IDE
 Products by Pathway  Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
Diseases associated with anti-NPPB antibodyOrgans/Tissues associated with anti-NPPB antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >142 publications with NPPB and Fibrosis
 Cardiovascular Diseases Antibodies  >74 publications with NPPB and Cardiovascular Diseases
 Heart Diseases Antibodies  >38 publications with NPPB and Heart Diseases
 Hypertension Antibodies  >27 publications with NPPB and Hypertension
 Hypertrophy Antibodies  >18 publications with NPPB and Hypertrophy
 Heart Failure Antibodies  >18 publications with NPPB and Heart Failure
 Edema Antibodies  >16 publications with NPPB and Edema
 Inflammation Antibodies  >15 publications with NPPB and Inflammation
 Necrosis Antibodies  >13 publications with NPPB and Necrosis
 Postoperative Complications Antibodies  >12 publications with NPPB and Postoperative Complications
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >146 publications with NPPB and Kidney
 Heart Antibodies  >91 publications with NPPB and Heart
 Lung Antibodies  >61 publications with NPPB and Lung
 Liver Antibodies  >44 publications with NPPB and Liver
 Pancreas Antibodies  >29 publications with NPPB and Pancreas
 Embryonic Tissue Antibodies  >16 publications with NPPB and Embryonic Tissue
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